Blar i Kavliinstitutt for nevrovitenskap på forfatter "Sandvig, Axel"
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Connectomics of morphogenetically engineered neurons as a predictor of functional integration in the ischemic brain
Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2019)Recent advances in cell reprogramming technologies enable the in vitro generation of theoretically unlimited numbers of cells, including cells of neural lineage and specific neuronal subtypes from human, including ... -
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
Hanssen, Katrine Sjaastad; Witter, Menno Peter; Sandvig, Axel; Sandvig, Ioanna; Kobro-Flatmoen, Asgeir (Peer reviewed; Journal article, 2023)Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part ... -
Generating Neural Networks from Ependymal Cells harvested after Spinal Cord Injury
Rem, Marit Trones (Master thesis, 2020)Traumatisk ryggmargsskader (tRMS) er preget av alvorlige, irreversible forstyrrelser av lokale og nevrale kretsløp i ryggmargen med ødeleggende effekt som når gjennom de supraspinale kanalene. Som svar på tRMS, blir ... -
Growing gold nanostructures for shape-selective cellular uptake
Bandyopadhyay, Sulalit; McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Raghunathan, Karthik; Sandvig, Axel; Sandvig, Ioanna; Andreassen, Jens-Petter; Glomm, Wilhelm (Journal article; Peer reviewed, 2018)With development in the synthesis of shape- and size-dependent gold (Au) nanostructures (NSs) and their applications in nanomedicine, one of the biggest challenges is to understand the interaction of these shapes with ... -
How does ALS pathology spread to affect healthy neurons? Recapitulation of disease progression in multi-nodal neural networks in vitro
Kollstrøm, Anna Mikalsen (Master thesis, 2020)Amyotrofisk lateral sklerose (ALS) er en nevrodegenerativ sykdom som påvirker øvre og nedre motornevroner, hvilket fører til en gradvis lammelse av muskler og som til slutt resulterer i død på grunn av respirasjonssvikt. ... -
Inhibiting the neuronal region with initial neurodegeneration: effects on neuropathology and behavior
Ebbesen, Nora Cecilie (Master thesis, 2021)Alzheimers sykdom er nevrodegenerativ og progressiv, og den vanligste årsaken til demens. Til tross for at Alzheimers er en økende global helse- og sosioøkonomisk bekymring, er ingen effektiv kur eller behandling tilgjengelig. ... -
Micro- and mesoscale neuroplasticity of in vitro cortical neuronal networks
Bie, Rikke (Master thesis, 2020)Bakgrunn: Aksonskade er et kjennetegn ved traumatiske skader tilført sentralnervesystemet (CNS). Pasienter lider ofte av langvarige funksjonsnedsettelser som et resultat av den komplekse patofysiologien assosiert med slike ... -
Self-organized Criticality in engineered in vitro networks; A balance of excitation and inhibition
Jordbræk, Sondre valentin (Master thesis, 2021)The emergence of critical dynamics has been associated with the balance of excitation to inhibition (E/I). The aim of this thesis was to explore the relationship of E/I balance with emergence of critical dynamics, stability ... -
Structural and functional dynamics of healthy and perturbed neuronal networks in vitro
Weir, Janelle Shari (Master thesis, 2019)Rapid advancement in the field of morphogenic neuroengineering has led to interesting research perspectives in the area of in vitro neural network modeling using human induced pluripotent stem cell (hiPSC) derived neural ... -
Using microdialysis to administer and assess drugs aimed at attenuating Alzheimer’s disease-related neuropathology
Hemler, Mary Elizabeth (Master thesis, 2021)Alzheimer’s disease is the most common form of dementia and is characterized by the neuropathological hallmarks amyloid-β and neurofibrillary tangles. Despite tremendous efforts in understanding the molecular, pathophysiological, ...