Blar i Institutt for sirkulasjon og bildediagnostikk på forfatter "Kaasa, Stein"
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An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay
Løhre, Erik Torbjørn; Thronæs, Morten; Brunelli, Cinzia; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2019)Purpose A clinical care pathway for pain management in a palliative care unit was studied with outcomes related to patients, physicians, and health care service. Mandatory use of patient-reported outcome measures (PROMs) ... -
Benefits of Study Participation for Patients with Advanced Cancer Receiving Radiotherapy: A Prospective Observational Study
Bye, Asta; Bjerkeset, Ellen; Stensheim, Hanne; Loge, Jon Håvard; Hjermstad, Marianne Jensen; Klepstad, Pål; Habberstad, Ragnhild H; Kaasa, Stein; Aass, Nina Kathrine (Peer reviewed; Journal article, 2022)Background: Patients with advanced cancer and bone metastases may have unmet palliative care (PC) needs that go unnoticed during clinical oncological practice. This observational study describes interventions that were ... -
Can variability in the effect of opioids on refractory breathlessness be explained by genetic factors?
Currow, David C.; Quinn, Stephen; Ekström, Magnus; Kaasa, Stein; Johnson, Miriam J.; Somogyi, Andrew A.; Klepstad, Pål (Journal article; Peer reviewed, 2015)Objectives: Opioids modulate the perception of breathlessness with a considerable variation in response, with poor correlation between the required opioid dose and symptom severity. The objective of this hypothesis-generating, ... -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, simone; Tadini, Valentina; Grosjean, Joel; Hatakeyama, Shinji; Tesfahun, Almaz Nigatu; Moestue, Siver Andreas; Kim, Jana; Nonstad, Unni; Romundstad, Pål Richard; Skorpen, Frank; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning; Strasser, Florian; Stephens, Nathan; Hoem, Dag; Molven, Anders; Kaasa, Stein; Fearon, Kenneth; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Clinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastases
Habberstad, Ragnhild H; Frøseth, Trude Camilla Salvesen; Aass, Nina Kathrine; Bjerkeset, Gunnhild; Abramova, Tatiana Mikhailovna; Garcia-Alonso, Elena; Caputo, Mariangela; Rossi, Romina; Boland, Jason W.; Brunelli, Cinzia; Lund, Jo-Åsmund; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2021)Background Radiotherapy (RT) reduces pain in about 60% of patients with painful bone metastases, leaving many patients without clinical benefit. This study assesses predictors for RT effectiveness in patients with painful ... -
Development and course of chronic widespread pain: the role of time and pain characteristics (the HUNT pain study)
Landmark, Tormod; Romundstad, Pål Richard; Butler, Stephen; Kaasa, Stein; Borchgrevink, Petter Chr. (Journal article; Peer reviewed, 2019)Chronic widespread pain (CWP) is common and associated with loss of functioning and health. Subjects with chronic nonwidespread pain (CnWP) are at increased risk of developing CWP, but few studies have described the nature ... -
From "breakthrough" to "episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations
Løhre, Erik T; Klepstad, Pål; Bennett, Michael I.; Brunelli, Cinzia; Caraceni, Augusto; Fainsinger, Robin L.; Knudsen, Anne Kari; Mercadante, Sebastiano; Sjøgren, Per; Kaasa, Stein (Journal article; Peer reviewed, 2016)Context Cancer pain can appear with spikes of higher intensity. Breakthrough cancer pain (BTCP) is the most common term for the transient exacerbations of pain, but the ability of the nomenclature to capture relevant ... -
Genetic and Non-genetic Factors Associated WithConstipation in Cancer Patients Receiving Opioids
Laugsand, Eivor Alette; Skorpen, Frank; Kaasa, Stein; Sabatowski, Rainer; Strasser, Florian; Fayers, Peter; Klepstad, Pål (Journal article; Peer reviewed, 2015)Objectives: To examine whether the inter-individual variation in constipation among patients receiving opioids for cancer pain is associated with genetic or non-genetic factors. Methods: Cancer patients receiving ... -
Genetic variation and cognitive dysfunction in opioid-treated patients with cancer
Kurita, Geana Paula; Ekholm, Ola; Kaasa, Stein; Klepstad, Pål; Skorpen, Frank; Sjøgren, Per (Peer reviewed; Journal article, 2016)Background and purpose The effects of single‐nucleotide polymorphisms (SNPs) on the cognitive function of opioid‐treated patients with cancer until now have not been explored, but they could potentially be related to ... -
Health care providers underestimate symptom intensities of cancer patients: A multicenter European study
Laugsand, Eivor Alette; Sprangers, Mirjam A. G.; Bjordal, Kristin; Skorpen, Frank; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2010)Background: Many patients with advanced cancer depend upon health care providers for symptom assessment. The extent of agreement between patient and provider symptom assessments and the association of agreement with ... -
Implementing a Standardized Care Pathway Integrating Oncology, Palliative Care and Community Care in a Rural Region of Mid-Norway
Brenne, Anne-Tove; Løhre, Erik T; Knudsen, Anne Kari; Thronæs, Morten; Lund, Jo-Åsmund; Kongshaug, Nina; Neverdal, Marte Nilssen; Rystad, Kristina Edvardsen; Johansen, Marianne Haug; Braseth, Tone Inga; Kaasa, Stein (Peer reviewed; Journal article, 2021)Introduction To improve quality across levels of care, we developed a standardized care pathway (SCP) integrating palliative and oncology services for hospitalized and home-dwelling palliative cancer patients in a rural ... -
Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases
Habberstad, Ragnhild H; Aass, Nina Kathrine; Mollnes, Tom Eirik; Damås, Jan Kristian; Brunelli, Cinzia; Rossi, Romina; Garcia-Alonso, Elena; Kaasa, Stein; Klepstad, Pål (Peer reviewed; Journal article, 2022)Context Inflammation is proposed to influence tumor response in radiotherapy (RT). Clinical studies to investigate the relationship between inflammatory markers and RT response is warranted to understand the variable RT ... -
Innate immune signalling genetics of pain, cognitive dysfunction and sickness symptoms in cancer pain patients treated with transdermal fentanyl
Barratt, Daniel T.; Klepstad, Pål; Dale, Ola; Kaasa, Stein; Somogyi, Andrew A. (Peer reviewed; Journal article, 2015)Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated ... -
Is there a genetic cause of appetite loss? - An explorative study in 1853 cancer patients
Solheim, Tora Skeidsvoll; Fayers, Peter; Fladvad, Torill; Tan, Ben; Skorpen, Frank; Fearon, Kenneth C.; Baracos, Vickie; Klepstad, Pål; Strasser, Florian; Kaasa, Stein (Journal article; Peer reviewed, 2012)Background Appetite loss has a major impact on cancer patients. It is exceedingly prevalent, is a prognostic indicator and is associated with inferior quality of life. Cachexia is a multi‐factorial syndrome defined by a ... -
Longitudinal Associations between Exercise and Pain in the General Population - The HUNT Pain Study
Landmark, Tormod; Romundstad, Pål Richard; Borchgrevink, Petter Chr.; Kaasa, Stein; Dale, Ola (Journal article; Peer reviewed, 2013)Background: Population-based studies have reported conflicting findings on the relationship between physical activity and pain, and most studies reporting a relationship are cross sectional. Temporal relationships are ... -
Measurement of health-related quality of life during chemotherapy -the importance of timing
Kristensen, Are Korsnes; Solheim, Tora Skeidsvoll; Amundsen, Tore; Hjelde, Harald Harris; Kaasa, Stein; Sørhaug, Sveinung; Grønberg, Bjørn Henning (Journal article; Peer reviewed, 2017)Background: Side effects of chemotherapy may occur at different time-points in the treatment cycle, and the exact assessment time relative to chemotherapy may affect HRQoL scores. The current study examined the variation ... -
Pain management index (PMI)-does it reflect cancer patients? wish for focus on pain?
Thronæs, Morten; Balstad, Trude Rakel; Brunelli, Cinzia; Løhre, Erik Torbjørn; Klepstad, Pål; Vagnildhaug, Ola Magne; Kaasa, Stein; Knudsen, Anne Kari; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)Background The pain management index (PMI) was developed to combine information about the prescribed analgesics and the self-reported pain intensity in order to assess physicians’ response to patients’ pain. However, ... -
The short-term impact of methylprednisolone on patient-reported sleep in patients with advanced cancer in a randomized, placebo-controlled, double-blind trial
Jakobsen, Gunnhild; Engstrøm, Morten; Hjermstad, Marianne Jensen; Rosland, Jan Henrik; Aass, Nina Kathrine; Albert, Eva; Kaasa, Stein; Fayers, Peter; Klepstad, Pål; Paulsen, Ørnulf (Peer reviewed; Journal article, 2020)Purpose: Although corticosteroids are frequently used in patients with advanced cancer, few studies have examined the impact of these drugs on patient-reported sleep. We aimed to examine the short-term impact of ... -
Sleep quality in hospitalized patients with advanced cancer: an observational study using self-reports of sleep and actigraphy
Jakobsen, Gunnhild; Engstrøm, Morten; Thronæs, Morten; Løhre, Erik Torbjørn; Kaasa, Stein; Fayers, Peter; Hjermstad, Marianne Jensen; Klepstad, Pål (Journal article; Peer reviewed, 2019)Purpose Although patients with advanced cancer report poor sleep quality, few studies have assessed sleep quality with a combination of subjective and objective measures. We aimed to examine sleep quality in hospitalized ... -
Sleep quality with WHO Step III opioid use for cancer pain
Jakobsen, Gunnhild; Engstrøm, Morten; Fayers, Peter; Hjermstad, Marianne Jensen; Kaasa, Stein; Kloke, Marianne; Sabatowski, Rainer; Klepstad, Pål (Journal article; Peer reviewed, 2018)Objective Sleep is often disturbed in patients with advanced cancer. There is limited knowledge about sleep in patients with cancer treated with strong opioids. This study examines sleep quality in patients with advanced ...