Blar i Institutt for sirkulasjon og bildediagnostikk på forfatter "Hak, Sjoerd"
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Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy
Zhao, Yiming; Fay, Francois; Hak, Sjoerd; Manuel Perez-Aguilar, Jose; Sanchez-Gaytan, Brenda L; Goode, Brandon; Duivenvoorden, Raphael; Davies, Ruth Catharina de Lange; Bjørkøy, Astrid; Weinstein, Harel; Fayad, Zahi A; Perez-Medina, Carlos; Mulder, Willem J M (Journal article; Peer reviewed, 2016)A major goal of cancer nanotherapy is to use nanoparticles as carriers for targeted delivery of anti-tumour agents. The drug–carrier association after intravenous administration is essential for efficient drug delivery to ... -
Cyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytes
Sofias, Alexandros Marios; Bjørkøy, Geir; Ochando, Jordi; Sønstevold, Linda; Hegvik, Maria; Davies, Catharina de Lange; Haraldseth, Olav; Lammers, Twan; Mulder, Willem J. M.; Hak, Sjoerd (Peer reviewed; Journal article, 2021)Active-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. ... -
Discovery of a new marker to identify myeloid cells associated with metastatic breast tumours
Bokil, Ansooya Avinash; Børkja, Mathieu; Wolowczyk, Camilla Izabel; Lamsal, Apsana; Prestvik, Wenche S.; Nonstad, Unni; Pettersen, Kristine; Andersen, Sonja Benedikte; Bofin, Anna M.; Bjørkøy, Geir; Hak, Sjoerd; Giambelluca, Miriam Soledad (Peer reviewed; Journal article, 2023)Background: Myeloid cells play an essential role in cancer metastasis. The phenotypic diversity of these cells during cancer development has attracted great interest; however, their functional heterogeneity and plasticity ... -
Hypoxic-ischemic brain injury: Melatonin treatment with lipid-based nanoparticles
Molska, Alicja (Doctoral thesis, 2021)Lave nivå av oksygen og begrenset blodforsyning rundt fødsel, også kjent som perinatal hypoksisk iskemi (HI), kan forårsake hjerneskade gjennom en progressiv kaskade (1). HIindusert hjerneskade er en av de viktigste årsakene ... -
L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles
McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm (Journal article; Peer reviewed, 2016)Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active ... -
Labeling nanoparticles: Dye leakage and altered cellular uptake
Snipstad, Sofie; Hak, Sjoerd; Baghirov, Habib; Sulheim, Einar; Mørch, Ýrr Asbjørg; Lelu, Sylvie; von Haartman, Eva; Bäck, Marcus; Nilsson, Peter R; Klymchenko, Andrey S; Davies, Ruth Catharina de Lange; Åslund, Andreas (Journal article, 2016)In vitro and in vivo behavior of nanoparticles (NPs) is often studied by tracing the NPs with fluorescent dyes. This requires stable incorporation of dyes within the NPs, as dye leakage may give a wrong interpretation of ... -
Liposomes - Human phagocytes interplay in whole blood: effect of liposome design
Giambelluca, Miriam Soledad; Markova, Elena; Louet, Claire; Steinkjer, Bjørg; Sundset, Rune; Skalko Basnet, Natasa; Hak, Sjoerd (Journal article; Peer reviewed, 2023)Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed ... -
Melatonin treatment for neonatal hypoxic ischemic brain injury: Translational barriers and how to break them
Nyman, Axel Karl Gottfrid (Doctoral theses at NTNU;2021:295, Doctoral thesis, 2021)Norsk sammendrag Hjerneskade i nyfødte (neonatal encefalopati, NE) er en vanlig lidelse med alvorlige konsekvenser for pasientene, deres familier og samfunnet. Den vanligste identifiserbare årsaken til NE er mangel på ... -
Mononuclear but Not Polymorphonuclear Phagocyte Depletion Increases Circulation Times and Improves Mammary Tumor-Homing Efficiency of Donor Bone Marrow-Derived Monocytes
Combes, Francis; Sofias, Alexandros Marios; Mc Cafferty, Séan; Huysmans, Hanne; De Temmerman, Joyca; Hak, Sjoerd; Meyer, Evelyne; Sanders, Niek N (Peer reviewed; Journal article, 2019)Tumor associated macrophages are an essential part of the tumor microenvironment. Consequently, bone marrow-derived monocytes (BMDMs) are continuously recruited to tumors and are therefore seen as ideal delivery vehicles ... -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery
Mørch, Ýrr Asbjørg; Hansen, Rune; Berg, Sigrid; Åslund, Andreas; Glomm, Wilhelm; Eggen, Siv; Schmid, Ruth; Johnsen, Heidi; Kubowicz, Stephan; Snipstad, Sofie; Sulheim, Einar; Hak, Sjoerd; Singh, Gurvinder; McDonagh, Birgitte Hjelmeland; Blom, Hans; Davies, Ruth Catharina de Lange; Stenstad, Per Martin (Journal article, 2015)Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ... -
Polyethylene glycol (PEG) as a broad applicability marker for LC–MS/MS-based biodistribution analysis of nanomedicines
Hyldbakk, Astrid; Hansen, Terkel; Hak, Sjoerd; Borgos, Sven Even F. (Journal article; Peer reviewed, 2024)Polyethylene glycol (PEG) conjugation (PEGylation) is a well-established strategy to improve the pharmacokinetic and biocompatibility properties of a wide variety of nanomedicines and therapeutic peptides and proteins. ... -
Simple and robust intravital microscopy procedures in hybrid TIE2GFP-BALB/c transgenic mice
Sofias, Alexandros Marios; Åslund, Andreas; Hagen, Nils; Grendstad, Kristin; Hak, Sjoerd (Peer reviewed; Journal article, 2019)Purpose The endeavor of deciphering intricate phenomena within the field of molecular medicine dictates the necessity to investigate tumor/disease microenvironment real-time on cellular level. We, hereby, design simple and ... -
Targeted nanoparticles for drug delivery and molecular imaging
Guercini, Emanuele (Master thesis, 2016)This study involved experiments on signal colocalization between αvβ3 integrin and RGD conjugated nanoemulsions as well as studies on nanoemulsion distribution and differences between the internalization patterns of RGD-NE ... -
Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking
Sofias, Alexandros Marios; Toner, Yohana C.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Soultanidis, Georgios; Elschot, Mattijs; Gonai, Haruki; Grendstad, Kristin; Flobak, Åsmund; Neckmann, Ulrike; Wolowczyk, Camilla; Fisher, Elizabeth L.; Reiner, Thomas; Davies, Catharina de Lange; Bjørkøy, Geir; Teunissen, Abraham J. P.; Ochando, Jordi; Pérez-Medina, Carlos; Mulder, Willem J. M.; Hak, Sjoerd (Journal article; Peer reviewed, 2020)Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ... -
Unraveling the multifaceted in vivo fate of cancer nanomedicine
Sofias, Alexandros Marios (Doctoral theses at NTNU;2019:369, Doctoral thesis, 2019)