Blar i Institutt for sirkulasjon og bildediagnostikk på forfatter "Damås, Jan Kristian"
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Association of Genetically Predicted Insomnia with Risk of Sepsis: A Mendelian Randomization Study
Thorkildsen, Marianne Thorkildsen; Gustad, Lise Tuset; Mohus, Randi Marie; Burgess, Stephen; Nilsen, Tom Ivar Lund; Damås, Jan Kristian; Rogne, Tormod (Peer reviewed; Journal article, 2023)Importance Insomnia has been associated with altered inflammatory response as well as increased risk of infections and sepsis in observational studies. However, these studies are prone to bias, such as residual confounding. ... -
Associations of obesity and lifestyle with the risk and mortality of bloodstream infection in a general population: a 15-year follow-up of 64 027 individuals in the HUNT Study
Paulsen, Julie; Askim, Åsa Susanne; Mohus, Randi Marie; Mehl, Arne; Dewan, Andrew; Solligård, Erik; Damås, Jan Kristian; Åsvold, Bjørn Olav (Journal article; Peer reviewed, 2017)Background: Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. Lifestyle factors are of particular interest since they represent a modifiable target. Methods: ... -
Avdekke, henvise og behandle personer med kronisk hepatitt C som følge av oppsøkende virksomhet
Svendsen, Therese (Master thesis, 2021)Innledning Kronisk Hepatitt C er en virussykdom som kan gi alvorlig leverskade og har høy forekomst blant personer som injiserer rusmidler. Med dagens behandling er det mulig å kurere så godt som alle med kronisk hepatitt ... -
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne, Tormod; Solligård, Erik; Burgess, Stephen; Brumpton, Ben Michael; Paulsen, Julie; Pescott, Hallie; Mohus, Randi Marie; Gustad, Lise Tuset; Mehl, Arne; Åsvold, Bjørn Olav; DeWan, Andrew; Damås, Jan Kristian (Journal article; Peer reviewed, 2020) -
Bronchial microdialysis monitoring of inflammatory response in open abdominal aortic aneurysm repair; an observational study.
Tyvold, Stig Sverre; Dahl, Torbjørn; Dragsund, Stein; Gunnes, Sigurd; Lyng, Oddveig; Damås, Jan Kristian; Aadahl, Petter; Solligård, Erik (Journal article; Peer reviewed, 2017)Aortic surgery results in ischemia–reperfusion injury that induces an inflammatory response and frequent complications. The magnitude of the inflammatory response in blood and bronchi may be associated with the risk of ... -
Burden of bloodstream infection in an area of Mid-Norway 2002-2013: A prospective population-based observational study
Mehl, Arne; Åsvold, Bjørn Olav; Lydersen, Stian; Paulsen, Julie; Solligård, Erik; Damås, Jan Kristian; Harthug, Stig; Edna, Tom-Harald (Journal article; Peer reviewed, 2017)Background Studies from several countries indicate that the incidence and mortality of bloodstream infection (BSI) have been increasing over time. Methods We studied the burden of disease and death related to BSI in ... -
Circulating levels of micronutrients and risk of infections: a Mendelian randomization study
Flatby, Helene Marie; Ravi, Anuradha; Damås, Jan Kristian; Solligård, Erik; Rogne, Tormod (Peer reviewed; Journal article, 2023)Background Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized ... -
Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab
Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar; Tøllefsen, Ingvild Maria; Ryan, Liv; Bendz, Bjørn; Hopp, Einar; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Andersen, Geir Øystein; Gullestad, Lars; Wiseth, Rune; Amundsen, Brage H.; Damås, Jan Kristian; Kleveland, Ola (Peer reviewed; Journal article, 2023)Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab ... -
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Holten, Aleksander Rygh; Kildal, Anders Benjamin; Lind, Andreas; Dyrhol-Riise, Anne Ma; Hoff, Dag Arne Lihaug; Müller, Fredrik; Solligård, Erik; Holter, Jan Cato; Afset, Jan Egil; Damås, Jan Kristian; Bergan, Jonas; Risnes, Kari; Muller, Karl Erik; Tonby, Kristian; Heggelund, Lars; Gustad, Lise Tuset; Grimsrud, Marit Mæhle; Dudman, Susanne Gjeruldsen; Folseraas, Trine; Skogen, Vegard; Hov, Johannes Espolin Roksund; Karlsen, Tom Hemming; Rühlemann, Malte C.; Arora, Jatin; Özer, Onur; Wacker, Eike Matthias; Wienbrandt, Lars; Ortiz, Aron Blandino; de Salazar, Adolfo; Chercoles, Adolfo Garrido; Palom, Adriana; Ruiz, Agustin; Garzia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Mayer, Alena; Bandera, Alessandra; Franke, Andre (Peer reviewed; Journal article, 2022)Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ... -
Direct and indirect effects of socioeconomic status on sepsis risk and mortality: a mediation analysis of the HUNT Study
Stensrud, Vilde; Gustad, Lise Tuset; Damås, Jan Kristian; Solligård, Erik; Krokstad, Steinar; Nilsen, Tom Ivar Lund (Peer reviewed; Journal article, 2023)Background Socioeconomic status (SES) may influence risk of sepsis and sepsis-related mortality, but to what extent lifestyle and health-related factors mediate this effect is not known. Methods The study included 65 227 ... -
Early identification and risk factors for sepsis-clinical and epidemiological studies
Askim, Åsa Susanne (Doctoral theses at NTNU;2018:161, Doctoral thesis, 2018)Denne avhandlingen fokuserer på risikofaktorer for sepsis; angst og depresjon, alder, kjønn, komorbiditet og livsstil, og vurderer ulike verktøy for tidlig identifisering av pasienter med sepsis. Sepsis rammer 30 millioner ... -
Early identification of sepsis in hospital inpatients by ward nurses increases 30-day survival
Torsvik, Malvin; Gustad, Lise; Mehl, Arne; Bangstad, Inger Lise; Vinje, Liv Jorun; Damås, Jan Kristian; Solligård, Erik (Journal article; Peer reviewed, 2016)Background: Systemic inflammatory response syndrome (SIRS) and sepsis are now frequently identified by observations of vital signs and detection of organ failure during triage in the emergency room. However, there is less ... -
Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway
Grønseth, Stine; Rogne, Tormod; Hannula, Raisa; Åsvold, Bjørn Olav; Afset, Jan Egil; Damås, Jan Kristian (Journal article; Peer reviewed, 2021) -
Epidemiology and outcome of sepsis in adult patients with Streptococcus pneumoniae infection in a Norwegian county 1993-2011: an observational study
Askim, Åsa Susanne; Mehl, Arne; Paulsen, Julie; DeWan, Andrew T.; VESTRHEIM, DIDRIK FRIMANN; Åsvold, Bjørn Olav; Damås, Jan Kristian; Solligård, Erik (Journal article; Peer reviewed, 2016)Background: Invasive pneumococcal disease (IPD) is responsible for significant mortality and morbidity worldwide. There are however few longitudinal studies on the changes in case fatality rate of IPD in recent years. ... -
Epidemiology and outcome of Staphylococcus aureusbloodstream infection and sepsis in a Norwegian county 1996–2011: an observational study
Paulsen, Julie; Mehl, Arne; Askim, Åsa Susanne; Solligård, Erik; Åsvold, Bjørn Olav; Damås, Jan Kristian (Journal article; Peer reviewed, 2015)Background: Staphylococcus aureus is one of the most common and lethal causes of bloodstream infection and the incidence is increasing. We carried out a prospective observational study of patients with Staphylococcus ... -
Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
Mohus, Randi Marie; Gustad, Lise Tuset; Furberg, Anne-Sofie; Moen, Martine Kjølberg; Liyanarachi, Kristin Vardheim; Askim, Åsa Susanne; Åsberg, Signe Elisabeth; DeWan, Andrew T.; Rogne, Tormod; Simonsen, Gunnar Skov; Nilsen, Tom Ivar Lund; Åsvold, Bjørn Olav; Damås, Jan Kristian; Solligård, Erik (Peer reviewed; Journal article, 2022)Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using ... -
High levels of discordant antimicrobial therapy in hospital-acquired bloodstream infections is associated with increased mortality in an intensive care, low antimicrobial resistance setting
Waagsbø, Bjørn; Stuve, Nora; Afset, Jan Egil; Klepstad, Pål; Mo, Skule; Heggelund, Lars; Damås, Jan Kristian (Peer reviewed; Journal article, 2022)Background Bloodstream infections (BSI) occur frequently and are associated with severe outcomes. In this study we aimed to investigate proportions of patients that received discordant empirical antimicrobial therapy and ... -
IL-6 receptor inhibition by tocilizumab attenuated expression of C5a receptor 1 and 2 in non-ST-elevation myocardial infarction
Orrem, Hilde Lang; Nilsson, Per; Pischke, Søren Erik; Kleveland, Ola; Yndestad, Arne; Ekholt, Karin; Damås, Jan Kristian; Espevik, Terje; Bendz, Bjørn; Halvorsen, Bente; Gregersen, Ida; Wiseth, Rune; Andersen, Geir Øystein; Ueland, Thor; Gullestad, Lars; Aukrust, Pål; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2018)Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their ... -
Incidence, case fatality and long-term outcomes in patients with sepsis - Nationwide registry studies of sepsis and COVID-19-related sepsis
Skei, Nina Vibeche (Doctoral theses at NTNU;2024:36, Doctoral thesis, 2024)Sepsis is a severe immune reaction to an infection that leads to acute organ dysfunction and is a common cause of hospitalization, morbidity, and death. After surviving sepsis, many patients experience health impairments ... -
Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
Liyanarachi, Kristin Vardheim; Solligård, Erik; Mohus, Randi Marie; Åsvold, Bjørn Olav; Rogne, Tormod; Damås, Jan Kristian (Peer reviewed; Journal article, 2022)Purpose Severe bacterial infections are important causes of hospitalization and loss of health worldwide. In this study we aim to characterize the total burden, recurrence and severity of bacterial infections in the ...