Blar i Institutt for sirkulasjon og bildediagnostikk på forfatter "Dale, Ola"
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Ambulance-attended opioid overdoses: An examination into overdose locations and the role of a safe injection facility
Madah-Amiri, Desiree; Skulberg, Arne Kristian; Braarud, Anne-Cathrine; Dale, Ola; Heyerdahl, Fridtjof; Lobmaier, Philipp Paul; Clausen, Thomas (Journal article; Peer reviewed, 2018)Background: Although the United States and numerous other countries are amidst an opioid overdose crisis, access to safe injection facilities remains limited. Methods: We used prospective data from ambulance journals in ... -
Characteristics of Opioid Overdoses and Intranasal Pharmacology of Naloxone
Skulberg, Arne Kristian (Doctoral theses at NTNU;2019:84, Doctoral thesis, 2019)Sammendrag Opioider, morfinlignende stoffer, fører til overdoser og dødsfall. I Norge dør rundt 250 mennesker hvert år. Disse dødsfallene kan i prinsippet forebygges. Det er økende fokus på skadereduserende tiltak, for ... -
European survey on national training activities in clinical research
Magnin, Anette; Iversen, Valentina Cabral; Calvo, Gonzalo; Cecetkova, Beata; Dale, Ola; Demlova, Regina; Blasko, George; Keane, Fionnuala; Kovács, Gabor G.; Levy-Marchal, Claire; Monteiro, Emilia; Palmisano, Lucia; Pella, Daniel; Portoles, Antonio; Rascol, Olivier; Schmied, Caecilia; Tay, Fabian; von der Leyen, Heiko; Ohmann, Christian (Journal article; Peer reviewed, 2019)Background Investigator-initiated clinical studies (IITs) are crucial to generate reliable evidence that answers questions of day-to-day clinical practice. Many challenges make IITs a complex endeavour, for example, ... -
Innate immune signalling genetics of pain, cognitive dysfunction and sickness symptoms in cancer pain patients treated with transdermal fentanyl
Barratt, Daniel T.; Klepstad, Pål; Dale, Ola; Kaasa, Stein; Somogyi, Andrew A. (Peer reviewed; Journal article, 2015)Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated ... -
International patent applications for non-injectable naloxone for opioid overdose reversal: Exploratory search and retrieve analysis of the Patent Scope database
McDonald, Rebecca; Danielsson Glende, Øyvind; Dale, Ola; Strang, John (Journal article; Peer reviewed, 2017)Issues. Non-injectable naloxone formulations are being developed for opioid overdose reversal, but only limited data have been published in the peer-reviewed domain. Through examination of a hitherto-unsearched database, ... -
Longitudinal Associations between Exercise and Pain in the General Population - The HUNT Pain Study
Landmark, Tormod; Romundstad, Pål Richard; Borchgrevink, Petter Chr.; Kaasa, Stein; Dale, Ola (Journal article; Peer reviewed, 2013)Background: Population-based studies have reported conflicting findings on the relationship between physical activity and pain, and most studies reporting a relationship are cross sectional. Temporal relationships are ... -
Naloksonnesespray – biotilgjengelighet og opptaksmønster i en fase 1-studie
Tylleskär, Ida; Skulberg, Arne Kristian; Nilsen, Turid; Skarra, Sissel; Dale, Ola (Journal article; Peer reviewed, 2019)Kameratredning med nalokson i nesespray kan forebygge dødsfall ved opioidoverdoser. For å få best mulig opptak av nalokson i nesen må sprayen gis med et lavt volum med høy medikamentkonsentrasjon. Målet med studien var å ... -
Naloxone for opioid overdose - Pharmacological aspects and dosing in clinical practice
Tylleskär, Ida Karin (Doctoral theses at NTNU;2020:236, Doctoral thesis, 2020)Dødsfall fra opioidoverdoser er et stort folkehelseproblem og utdeling av nesespray med motgiften nalokson var foreslått som et tiltak for å redde liv. I 2012 fantes det ingen godkjente nesesprayer på markedet. Istedenfor ... -
Nasal naloxone - A pilot study of the pharmacokinetics of a concentrated formulation
Tylleskär, Ida Karin (Master thesis, 2017)Introduction: Naloxone is the antidote against heroin and other opioids. As a measure to combat overdose deaths, nasal naloxone is wanted for bystander administration by lay people. The objective of this study was to ... -
NTNU intranasal naloxone trial (NINA-1) study protocol for a double-blind, double-dummy, non-inferiority randomised controlled trial comparing intranasal 1.4 mg to intramuscular 0.8 mg naloxone for prehospital use
Skulberg, Arne Kristian; Tylleskär, Ida; Braarud, Anne-Cathrine; Dale, Jostein; Heyerdahl, Fridtjof; Mellesmo, Sindre; Valberg, Morten; Dale, Ola (Peer reviewed; Journal article, 2020)Abstract Introduction Intranasal naloxone is widely used to treat opioid overdoses. The advantage of nasal administration compared to injection lies in its suitability for administration by lay people as it is needless. ... -
Pharmacodynamics and arteriovenous difference of intravenous naloxone in healthy volunteers exposed to remifentanil
Tylleskär, Ida; Skulberg, Arne Kristian; Skarra, Sissel; Nilsen, Turid; Dale, Ola (Journal article; Peer reviewed, 2018)Purpose Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known ... -
The pharmacokinetic interaction between nasally administered naloxone and the opioid remifentanil in human volunteers
Tylleskär, Ida; Skarra, Sissel; Skulberg, Arne Kristian; Dale, Ola (Journal article; Peer reviewed, 2021)Purpose Remifentanil has been shown to increase the bioavailability of nasally administered naloxone. The aim of this study was to explore the nature of this observation. Methods We analysed samples from three pharmacokinetic ... -
Pharmacokinetics and -dynamics of intramuscular and intranasal naloxone: an explorative study in healthy volunteers
Skulberg, Arne Kristian; Tylleskär, Ida; Nilsen, Turid; Skarra, Sissel; Salvesen, Øyvind; Sand, Trond; Loftsson, Thorsteinn; Dale, Ola (Journal article; Peer reviewed, 2018)Purpose This study aimed to develop a model for pharmacodynamic and pharmacokinetic studies of naloxone antagonism under steady-state opioid agonism and to compare a high-concentration/low-volume intranasal naloxone ... -
Pharmacokinetics of a new, nasal formulation of naloxone
Tylleskär, Ida; Skulberg, Arne Kristian; Nilsen, Turid; Skarra, Sissel; Jansook, Phatsawee; Dale, Ola (Journal article; Peer reviewed, 2017)Purpose Nasal naloxone is wanted for bystander administration in opioid overdose and as a needle-free alternative for emergency medical personnel. Epidemiologic studies have indicated a therapeutic effect of bystander ... -
Pharmacokinetics of a novel, approved, 1.4-mg intranasal naloxone formulation for reversal of opioid overdose—a randomized controlled trial
Skulberg, Arne Kristian; Åsberg, Anders; Zare, Hasse Khiabani; Røstad, Hilde; Tylleskär, Ida; Dale, Ola (Peer reviewed; Journal article, 2019)Background and aims Intranasal (i.n.) naloxone is an established treatment for opioid overdose. Anyone likely to witness an overdose should have access to the antidote. We aimed to determine whether an i.n. formulation ... -
Prehospital naloxone administration – what influences choice of dose and route of administration?
Tylleskär, Ida; Gjersing, Linn; Bjørnsen, Lars Petter Bache-Wiig; Braarud, Anne-Cathrine; Heyerdahl, Fridtjof; Dale, Ola; Skulberg, Arne Kristian (Peer reviewed; Journal article, 2020)Background Amidst the ongoing opioid crisis there are debates regarding the optimal route of administration and dosages of naloxone. This applies both for lay people administration and emergency medical services, and in ... -
Prevalence of use of non-prescription analgesics in the Norwegian HUNT3 population: Impact of gender, age, exercise and prescription of opioids
Dale, Ola; Borchgrevink, Petter Chr.; Fredheim, Olav Magnus; Mahic, Milada; Romundstad, Pål Richard; Skurtveit, Svetlana (Journal article; Peer reviewed, 2015)Background: There are concerns about potential increasing use of over-the-counter (OTC) analgesics. The aims of this study were to examine 1) the prevalence of self-reported use of OTC analgesics; 2) the prevalence of ... -
Take-home naloxone for the emergency interim management of opioid overdose: The public health application of an emergency medicine
Strang, John; McDonald, Rebecca; Campbell, Gabrielle; Degenhardt, Louisa; Nielsen, Suzanne; Ritter, Alison; Dale, Ola (Peer reviewed; Journal article, 2019)Naloxone is a well-established essential medicine for the treatment of life-threatening heroin/opioid overdose in emergency medicine. Over two decades, the concept of ‘take-home naloxone’ has evolved, comprising pre-provision ... -
The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses
Skorpen, Frank; von Hofacker, Sebastian; Bjørngaard, Mads; Skogholt, Anne Heidi; Dale, Ola; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2016)BACKGROUND: Genetic variability contributes to variable clinical response to opioids. This study emerged from the observation of three Norwegian patients who showed no or extraordinary poor response to very high doses of ...