Blar i Institutt for samfunnsmedisin og sykepleie på tidsskrift "Nature Communications"
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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
(Journal article; Peer reviewed, 2014)Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. ... -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(Journal article; Peer reviewed, 2016)Large consortia have revealed hundreds of genetic loci associated with anthropometric traits,one trait at a time. We examined whether genetic variants affect body shape as a compositephenotype that is represented by a ... -
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
(Peer reviewed; Journal article, 2020)Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and ... -
The blood proteome of imminent lung cancer diagnosis
(Peer reviewed; Journal article, 2023)Identification of risk biomarkers may enhance early detection of smoking-related lung cancer. We measured between 392 and 1,162 proteins in blood samples drawn at most three years before diagnosis in 731 smoking-matched ... -
The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
(Peer reviewed; Journal article, 2022)Alzheimer’s disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of the UK Biobank ... -
Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci
(Peer reviewed; Journal article, 2022)Hernias are characterized by protrusion of an organ or tissue through its surrounding cavity and often require surgical repair. In this study we identify 65,492 cases for five hernia types in the UK Biobank and perform ... -
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals
(Journal article; Peer reviewed, 2021)Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ... -
Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data
(Peer reviewed; Journal article, 2021)Estimation of direct and indirect (i.e. parental and/or sibling) genetic effects on phenotypes is becoming increasingly important. We compare several multivariate methods that utilize summary results statistics from ... -
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
(Peer reviewed; Journal article, 2023)Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery ... -
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese
(Journal article; Peer reviewed, 2015)Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional ... -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
(Peer reviewed; Journal article, 2016)Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ... -
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
(Journal article; Peer reviewed, 2018)Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve ... -
Genome-wide analysis yields new loci associating with aortic valve stenosis
(Journal article; Peer reviewed, 2018)Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 ... -
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
(Journal article; Peer reviewed, 2019)Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ... -
Genome-wide association meta-analysis identifies 29 new acne susceptibility loci
(Peer reviewed; Journal article, 2022)Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely inflamed lesions may leave permanent scars that have been associated with long-term psychosocial consequences. Here, we perform ... -
Genome-wide association study identifies multiple risk loci for renal cell carcinoma
(Journal article; Peer reviewed, 2017)Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing ... -
Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth
(Journal article; Peer reviewed, 2019) -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
(Journal article; Peer reviewed, 2017)Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ... -
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
(Peer reviewed; Journal article, 2020)Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ... -
Identification of three bacterial species associated with increased appendicular lean mass: the HUNT study
(Peer reviewed; Journal article, 2023)Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. ...