Blar i Institutt for samfunnsmedisin og sykepleie på tidsskrift "Nature Communications"
Viser treff 1-17 av 17
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A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus
(Journal article; Peer reviewed, 2014)Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. ... -
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
(Journal article; Peer reviewed, 2016)Large consortia have revealed hundreds of genetic loci associated with anthropometric traits,one trait at a time. We examined whether genetic variants affect body shape as a compositephenotype that is represented by a ... -
Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
(Peer reviewed; Journal article, 2020)Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization analyses and ... -
Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals
(Journal article; Peer reviewed, 2021)Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ... -
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese
(Journal article; Peer reviewed, 2015)Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional ... -
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
(Peer reviewed; Journal article, 2016)Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ... -
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes
(Journal article; Peer reviewed, 2018)Angiopoietin-like 4 (ANGPTL4) is an endogenous inhibitor of lipoprotein lipase that modulates lipid levels, coronary atherosclerosis risk, and nutrient partitioning. We hypothesize that loss of ANGPTL4 function might improve ... -
Genome-wide analysis yields new loci associating with aortic valve stenosis
(Journal article; Peer reviewed, 2018)Aortic valve stenosis (AS) is the most common valvular heart disease, and valve replacement is the only definitive treatment. Here we report a large genome-wide association (GWA) study of 2,457 Icelandic AS cases and 349,342 ... -
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
(Journal article; Peer reviewed, 2019)Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ... -
Genome-wide association study identifies multiple risk loci for renal cell carcinoma
(Journal article; Peer reviewed, 2017)Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing ... -
Genome-wide association study reveals dynamic role of genetic variation in infant and early childhood growth
(Journal article; Peer reviewed, 2019) -
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
(Journal article; Peer reviewed, 2017)Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ... -
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer
(Peer reviewed; Journal article, 2020)Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ... -
Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort
(Peer reviewed; Journal article, 2020)There is a robust observational relationship between lower birthweight and higher risk of cardiometabolic disease in later life. The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that adverse ... -
MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk
(Peer reviewed; Journal article, 2020)A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the ... -
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve
(Journal article; Peer reviewed, 2017)Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 BAV cases and 4,660 age, sex and ... -
Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis
(Journal article; Peer reviewed, 2019)Chronic kidney disease (CKD) is a growing health burden currently affecting 10–15% of adults worldwide. Estimated glomerular filtration rate (eGFR) as a marker of kidney function is commonly used to diagnose CKD. We analyze ...