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    • Stroke genetics informs drug discovery and risk prediction across ancestries 

      Mishra, Aniket; Malik, Rainer; Hachiya, Tsuyoshi; Jürgenson, Tuuli; Namba, Shinichi; Posner, Daniel C.; Kamanu, Frederick K.; Koido, Masaru; Le Grand, Quentin; Shi, Mingyang; He, Yunye; Georgakis, Marios K.; Caro, Ilana; Krebs, Kristine; Liaw, Yi-Ching; Vaura, Felix C.; Lin, Kuang; Winsvold, Bendik K S; Srinivasasainagendra, Vinodh; Parodi, Livia; Bae, Hee-Joon; Chauhan, Ganesh; Tomppo, Liisa; Akinyemi, Rufus; Roshchupkin, Gennady V.; Habib, Naomi; Jee, Yon Ho; Thomassen, Jesper Qvist; Abedi, Vida; Cárcel-Márquez, Jara; Nygaard, Marianne; Leonard, Hampton L.; Yang, Chaojie; Yonova-Doing, Ekaterina; Knol, Maria J.; Lewis, Adam J.; Judy, Renae L.; Ago, Tetsuro; Amouyel, Philippe; Armstrong, Nicole D.; Bakker, Mark K.; Bartz, Traci M.; Bennett, David A.; Bis, Joshua C.; Bordes, Constance; Børte, Sigrid; Cain, Anael; Ridker, Paul M.; Cho, Kelly; Chen, Zhengming; Cruchaga, Carlos; Cole, John W.; de Jager, Phil L.; de Cid, Rafael; Endres, Matthias; Ferreira, Leslie E.; Geerlings, Mirjam I.; Gasca, Natalie C.; Gudnason, Vilmundur; Hata, Jun; He, Jing; Heath, Alicia K.; Ho, Yuk-Lam; Havulinna, Aki S.; Hopewell, Jemma C.; Hyacinth, Hyacinth I.; Inouye, Michael; Jacob, Mina A.; Jeon, Christina E.; Jern, Christina; Kamouchi, Masahiro; Keene, Keith L.; Kitazono, Takanari; Kittner, Steven J.; Konuma, Takahiro; Kumar, Amit; Lacaze, Paul; Launer, Lenore J.; Lee, Keon-Joo; Lepik, Kaido; Li, Jiang; Li, Liming; Manichaikul, Ani; Markus, Hugh S.; Marston, Nicholas A.; Meitinger, Thomas; Mitchell, Braxton D.; Montellano, Felipe A.; Morisaki, Takayuki; Mosley, Thomas H.; Nalls, Mike A.; Nordestgaard, Børge G; O'Donnell, Martin J.; Okada, Yukinori; Onland-Moret, N Charlotte; Ovbiagele, Bruce; Peters, Annette; Psaty, Bruce M.; Rich, Stephen S.; Rosand, Jonathan; Sabatine, Marc S.; Sacco, Ralph L.; Saleheen, Danish; Sandset, Else Charlotte; Salomaa, Veikko; Sargurupremraj, Muralidharan; Sasaki, Makoto; Satizabal, Claudia L.; Schmidt, Carsten O.; Shimizu, Atsushi; Smith, Nicholas L.; Sloane, Kelly L.; Sutoh, Yoichi; Sun, Yan V.; Tanno, Kozo; Tiedt, Steffen; Tatlisumak, Turgut; Torres-Aguila, Nuria P.; Tiwari, Hemant K.; Trégouët, David-Alexandre; Trompet, Stella; Tuladhar, Anil Man; Tybjærg-Hansen, Anne; van Vugt, Marion; Vibo, Riina; Verma, Shefali S.; Wiggins, Kerri L.; Wennberg, Patrik; Woo, Daniel; Wilson, Peter W F; Xu, Huichun; Yang, Qiong; Yoon, Kyungheon; Millwood, Iona Y.; Gieger, Christian; Ninomiya, Toshiharu; Grabe, Hans J.; Jukema, J Wouter; Rissanen, Ina L.; Strbian, Daniel; Kim, Young Jin; Chen, Pei-Hsin; Mayerhofer, Ernst; Howson, Joanna M M; Irvin, Marguerite R.; Adams, Hieab; Wassertheil-Smoller, Sylvia; Christensen, Kaare; Ikram, Mohammad A.; Rundek, Tatjana; Worrall, Bradford B.; Lathrop, G Mark; Riaz, Moeen; Simonsick, Eleanor M.; Kõrv, Janika; França, Paulo H C; Zand, Ramin; Prasad, Kameshwar; Frikke-Schmidt, Ruth; de Leeuw, Frank-Erik; Liman, Thomas; Haeusler, Karl Georg; Ruigrok, Ynte M.; Heuschmann, Peter Ulrich; Longstreth, W.T.; Jung, Keum Ji; Bastarache, Lisa; Paré, Guillaume; Damrauer, Scott M.; Chasman, Daniel I.; Rotter, Jerome I.; Anderson, Christopher D.; Zwart, John Anker Henrik; Niiranen, Teemu J.; Fornage, Myriam; Liaw, Yung-Po; Seshadri, Sudha; Fernández-Cadenas, Israel; Walters, Robin G.; Ruff, Christian T.; Owolabi, Mayowa O.; Huffman, Jennifer E.; Milani, Lili; Kamatani, Yoichiro; Dichgans, Martin; Debette, Stephanie (Peer reviewed; Journal article, 2022)
      Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of ...
    • Cohort profile: the Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) - a national research and quality registry with a biomaterial collection 

      Medbøen, Ingrid Tøndel; Persson, Karin Ester Torun; Nåvik, Marit; Totland, Torunn Holm; Bergh, Sverre; Treviño, Cathrine Selnes; Ulstein, Ingun; Engedal, Knut; Knapskog, Anne Brita; Brækhus, Anne; Øksengård, Anne Rita; Horndalsveen, Peter Otto; Saltvedt, Ingvild; Lyngroth, Anne Liv; Ranhoff, Anette Hylen; Skrettingland, Dagny B; Naik, Mala; Soares, Jelena Zugic; Johnsen, Bente; Selbæk, Geir (Peer reviewed; Journal article, 2022)
      Purpose The Norwegian Registry of Persons Assessed for Cognitive Symptoms (NorCog) was established to harmonise and improve the quality of diagnostic practice across clinics assessing persons with cognitive symptoms in ...
    • MRI-assessed tumor-free distance to serosa predicts deep myometrial invasion and poor outcome in endometrial cancer 

      Dybvik, Julie Andrea; Fasmer, Kristine Eldevik; Ytre-Hauge, Sigmund; Husby, Jenny Hild Aase; Salvesen, Øyvind; Stefansson, Ingunn Marie; Krakstad, Camilla; Trovik, Jone; Haldorsen, Ingfrid S. (Peer reviewed; Journal article, 2022)
      Objectives To explore the diagnostic accuracy of preoperative magnetic resonance imaging (MRI)-derived tumor measurements for the prediction of histopathological deep (≥ 50%) myometrial invasion (pDMI) and prognostication ...
    • The role of leptin levels in adaptation to cold climates 

      Nikanorova, Alena A.; Barashkov, Nikolay A.; Nakhodkin, Sergey S.; Pshennikova, Vera G.; Solovyev, Aisen V.; Romanov, Georgii P.; Kuzmina, Sargylana S.; Sazonov, Nikolay N.; Burtseva, Tatiana E.; Odland, Jon Øyvind; Fedorova, Sardana A. (Peer reviewed; Journal article, 2020)
      Currently, adipose tissue is considered an endocrine organ that produces hormone-active substances, including leptin, which can play a key role in thermoregulation processes. Therefore, we performed a meta-analysis to ...
    • Physical activity and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies 

      Aune, Dagfinn; Sen, Abhijit; Kobeissi, Elsa; Hamer, Mark; Norat, Teresa; Riboli, Elio (Journal article; Peer reviewed, 2020)
      The association between physical activity and risk of abdominal aortic aneurysm has been inconsistent with some studies reporting a reduced risk while others have found no association. We conducted a systematic review and ...
    • Core Values and Principles of Nordic General Practice/Family Medicine 

      Nordic Federation of, General Practice; Sigurdsson, Johann Agust; Beich, Anders; Auvinen, Juha; Isacson, Magnus; Kvittum Tangen, Marte; Arnardottir, Salóme Ásta; Hørslev, Louise; Bernad, Sanne (Journal article; Peer reviewed, 2020)
    • Subjective working memory predicts objective memory in cognitively normal aging: a HUNT study 

      Bosnes, Ole; Almkvist, Ove; Bosnes, Ingunn; Stordal, Eystein (Peer reviewed; Journal article, 2020)
      Background Recent studies have shown that subjective memory is multi-, rather than uni-dimensional, in line with the results of objective memory tests. The purpose of this study was to investigate whether there is an ...
    • Active components of commonly prescribed medicines affect influenza a virus–host cell interaction: A pilot study 

      Ianevski, Aleksandr; Yao, Rouan; Zusinaite, Eva; Lysvand, Hilde; Oksenych, Valentyn; Tenson, Tanel; Bjørås, Magnar; Kainov, Denis (Peer reviewed; Journal article, 2021)
      Background: Every year, millions of people are hospitalized and thousands die from influenza A virus (FLUAV) infection. Most cases of hospitalizations and death occur among the elderly. Many of these elderly patients are ...
    • Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit 

      Bolkan, Håkon Angell; National Audit of Small Bowel, NASBO Collaborators (Peer reviewed; Journal article, 2020)
      Background Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition ...
    • Using Genomic Structural Equation Modeling to Partition the Genetic Covariance Between Birthweight and Cardiometabolic Risk Factors into Maternal and Offspring Components in the Norwegian HUNT Study 

      Moen, Gunn-Helen Øiseth; Nivard, Michel; Bhatta, Laxmi; Warrington, Nicole Maree; Willer, Cristen; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M. (Peer reviewed; Journal article, 2022)
      The Barker Hypothesis posits that adverse intrauterine environments result in fetal growth restriction and increased risk of cardiometabolic disease through developmental compensations. Here we introduce a new statistical ...
    • Disease-Course Adapting Machine Learning Prognostication Models in Elderly Patients Critically Ill With COVID-19: Multicenter Cohort Study With External Validation 

      Jung, Christian; Mamandipoor, Behrooz; Fjølner, Jesper; Bruno, Raphael Romano; Wernly, Bernhard; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Wolff, Georg; Kelm, Malte; Beil, Michael; Sviri, Sigal; van Heerden, Peter V.; Szczeklik, Wojciech; Czuczwar, Miroslaw; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Cecconi, Maurizio; Leaver, Susannah; De Lange, Dylan W.; Guidet, Bertrand; Flaatten, Hans Kristian; Osmani, Venet (Peer reviewed; Journal article, 2022)
      Background:The COVID-19 pandemic caused by SARS-CoV-2 is challenging health care systems globally. The disease disproportionately affects the elderly population, both in terms of disease severity and mortality risk. ...
    • Psychological distress among caregivers of children with neurodevelopmental disorders in Nepal 

      Maridal, Hans Kristian; Bjørgaas, Hanne Marit; Hagen, Kristen; Jonsbu, Egil; Mahat, Pashupati; Malakar, Shankar; Dørheim, Signe Karen (Peer reviewed; Journal article, 2021)
      Parenting a child with neurodevelopmental disorder (NDD) is related to a higher rate of anxiety and depression, increased stress, and reduced quality of life. Although there is reason to believe that parenting children ...
    • Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study 

      Wolff, Georg; Wernly, Bernhard; Flaatten, Hans Kristian; Fjølner, Jesper; Bruno, Raphael Romano; Artigas, Antonio; Pinto, Bernardo Bollen; Schefold, Joerg C.; Kelm, Malte; Binneboessel, Stephan; Baldia, Philipp; Beil, Michael; Sivri, Sigal; van Heerden, Peter Vernon; Szczeklik, Wojciech; Elhadi, Muhammed; Joannidis, Michael; Oeyen, Sandra; Flamm, Maria; Zafeiridis, Tilemachos; Marsh, Brian; Andersen, Finn Husøy; Moreno, Rui; Boumendil, Ariane; De Lange, Dylan W.; Guidet, Bertrand; Leaver, Susannah; Jung, Christian (Peer reviewed; Journal article, 2022)
      Purpose Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific ...
    • High ward occupancy, bedspacing, and 60 day mortality for patients with myocardial infarction, stroke, and heart failure 

      Asheim, Andreas; Nilsen, Sara Marie; Aam, Stina; Anthun, Kjartan Sarheim; Carlsen, Fredrik; Janszky, Imre; Vatten, Lars Johan; Bjørngaard, Johan Håkon (Journal article; Peer reviewed, 2022)
      Abstract Aims To study the consequences of crowded wards among patients with cardiovascular disease. Methods and results This is a cohort study among 201 801 patients with 258 807 admissions who were acutely admitted for ...
    • Exploring drug cost and disease outcome in rheumatoid arthritis patients treated with biologic and targeted synthetic DMARDs in Norway in 2010–2019 – a country with a national tender system for prescription of costly drugs 

      Brkic, Alen; Diamantopoulos, Andreas P; Haavardsholm, Espen A.; Fevang, Bjørg Tilde Svanes; Brekke, Lene Kristin; Loli, Liz Paucar; Zettel, Camilla; Rødevand, Erik; Bakland, Gunnstein; Pawel, Mielnik; Haugeberg, Glenn (Peer reviewed; Journal article, 2022)
      Background In Norway, an annual tender system for the prescription of biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) has been used since 2007. This study aimed to explore annual ...
    • Validity of Estimated Cardiorespiratory Fitness in Patients With Primary Breast Cancer 

      Michalski, Meghan; Rowed, Kylie; Lavery, Jessica A; Moskowitz, Chaya S; Capaci, Catherine; Stene, Guro Birgitte; Edvardsen, Elisabeth; Eves, Neil D; Jones, Lee W.; Scott, Jessica M (Peer reviewed; Journal article, 2022)
      Background Estimated peak oxygen consumption (Vo2peak) is widely used in oncology; however, estimated Vo2peak equations were developed in noncancer settings. Objectives The aim of this study was to evaluate the ...
    • Comparing the impact of vaccination strategies on the spread of COVID-19, including a novel household-targeted vaccination strategy 

      Voigt, Andre; Omholt, Stig William; Almaas, Eivind (Peer reviewed; Journal article, 2022)
      With limited availability of vaccines, an efficient use of the limited supply of vaccines in order to achieve herd immunity will be an important tool to combat the wide-spread prevalence of COVID-19. Here, we compare a ...
    • Air versus Sulfur Hexafluoride Gas Tamponade for Small and Medium-Sized Macular Holes: A Randomized Noninferiority Trial 

      Lindtjørn, Birger; Krohn, Jørgen Gitlesen; Haugstad, Marta; Stene-Johansen, Ingar; Austeng, Dordi; Basit, Samy; Fossen, Kristian Anker; Varhaug, Pål; Kvaløy, Jan Terje; Forsaa, Vegard Asgeir (Peer reviewed; Journal article, 2022)
      Purpose To investigate whether air tamponade is noninferior to sulfur hexafluoride (SF6) gas tamponade for small (≤ 250 μm) and medium-sized (> 250 μm and ≤ 400 μm) macular holes (MHs). Design Multicenter, randomized ...
    • Six versus 2 weeks treatment with doxycycline in European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blinded, randomised and placebo-controlled trial 

      Solheim, Anne Marit; Lorentzen, Åslaug Rudjord; Dahlberg, Audun Olav; Flemmen, Heidi Øyen; Brune, Synne; Forselv, Kristine Johanne Nordstrøm; Pripp, Are Hugo; Bø, Margrete Halvorsen; Eikeland, Randi; Reiso, Harald; Mygland, Åse Daasvand; Ljøstad, Unn (Peer reviewed; Journal article, 2022)
      Background: There is limited evidence regarding optimal duration of antibiotic treatment in neuroborreliosis. We aimed to compare efficacy and safety of oral doxycycline for 2 and 6 weeks in European Lyme neuroborreliosis ...
    • Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets 

      Martins, Catia; Røkenes, Jessica Ann; Gower, Barbara A.; Hunter, Gary R. (Peer reviewed; Journal article, 2021)
      Background: The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes. ...