Blar i Fakultet for medisin og helsevitenskap (MH) på tittel
Viser treff 14402-14421 av 15069
-
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG
(Journal article; Peer reviewed, 2017)Both a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional ... -
Uracil DNA Glycosylase UNG2 carrying the germline mutation Arg88Cys: Potential implications for adaptive immunity and cancer
(Master thesis, 2011)Uracil is normally found in RNA where it replaces the DNA base thymine. However, it can occur in DNA if misincorporated in place of thymine, or as a result of deamination of cytosine. Uracil is also a normal intermediate ... -
Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A
(Journal article; Peer reviewed, 2011)Uracil is removed from DNA by the conserved enzyme Uracil DNA N-glycosylase (UNG). Previously, we observed that inhibiting UNG in Xenopus egg extracts blocked assembly of CENP-A, a histone H3 variant. CENP-A is an essential ... -
Uracil in DNA - necessary intermediate for antibody maturation and mutagenic lesion
(Doctoral thesis at NTNU;2015:153, Doctoral thesis, 2015)Uracil in DNA - et viktig mellomprodukt for adaptiv immunitet og mutagen skade Uracil er en av fire nukleobaser i RNA, men små mengder kan også befinne seg i DNA. Det er to kilder til genomisk uracil: misinkorporering ... -
Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil
(Journal article; Peer reviewed, 2019)UNG is the major uracil-DNA glycosylase in mammalian cells and is involved in both error-free base excision repair of genomic uracil and mutagenic uracil-processing at the antibody genes. However, the regulation of UNG in ... -
Uracil-DNA glycosylase, activation-induced deaminase and regulation of adaptive immune responses
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:318, Doctoral thesis, 2012)Uracil-DNA glykosylase, activation-induced deaminase og regulering av ervervet immunitet Det eksterne miljøet er rikt på potensielle farer for alle multicellulære organismer. Det mammalske immunforsvaret er en barriere ... -
Urban–Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study
(Journal article; Peer reviewed, 2019)Higher hip fracture incidence in urban than in rural areas has been demonstrated, but urban–rural differences in posthip fracture mortality have been less investigated, and the results are disparate. Hence, the aims of the ... -
Ureteric injuries during hysterectomy—A Norwegian retrospective study of occurrence and claims for compensation over an 11-year period
(Peer reviewed; Journal article, 2021)Introduction: Ureteric injury is a rare but serious, iatrogenic complication of hysterectomy. The risk depends on indication for surgery, predisposing risk factors, and peroperative conditions. Our aims were to evaluate ... -
Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway
(Journal article; Peer reviewed, 2013)Objective: To investigate urine albumin leakage as a marker of endothelial dysfunction in migraine patients. Design: A population-based health study. Participants: 303 patients with migraine, 1009 patients with ... -
Urinary and colorectal-anal distress in women - prevalence, risk factors and effect of pelvic floor muscle exercise in women with pelvic organ prolapse
(Doctoral theses at NTNU;2021:199, Doctoral thesis, 2021) -
Urinary detection of corticosteroid in topical treatment of skin disease by 19F MRS
(Journal article; Peer reviewed, 2019)Objective To investigate if it was feasible to quantify the renal excretion of topically applied corticosteroids by 19F MRS. Materials and methods Five participants, one healthy and four with skin diseases, were treated ... -
Urinary incontinence and drug use: Data from the Norwegian Prescription Database and the HUNT3 study
(Doctoral theses at NTNU;2018:125, Doctoral thesis, 2018)Introduction Urinary incontinence is a common health problem in the female population. The most common drug group used for the treatment of urgency urinary incontinence is anticholinergic drugs, including oxybutynin, ... -
Urinary Incontinence and Urinary Tract Infections in the Elderly: Risk Factors and Consequences
(Doktoravhandlinger ved NTNU, 1503-8181; 2012:342, Doctoral thesis, 2012) -
Urinary incontinence during pregnancy and after delivery - effect of pelvic floor muscle training in prevention and treatment
(Dissertations at the Faculty of Medicine; 220, Doctoral thesis, 2003)The primary aim of this thesis was to increase knowledge about the prevention of or treatment for urinary incontinence related to pregnancy and delivery. To achieve this we evaluated the effect of pelvic floor muscle ... -
Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria
(Journal article; Peer reviewed, 2015)Background: The contrast between a high prevalence of chronic kidney disease (CKD) and the low incidence of end-stage renal disease highlights the need for new biomarkers of progression beyond albuminuria testing. ... -
Urinveisinfeksjoner ved St. Olavs hospital HF
(Master thesis, 2020)Urinveisinfeksjoner (UVI) er blant de vanligste bakterielle infeksjonene og er årsak til en betydelig andel av antibiotikaforbruket i Norge. Over halvparten av alle kvinner vil gjennomgå én eller flere tilfeller av UVI i ... -
Uro hos personer med demens
(Bachelor thesis, 2020)Bakgrunn: Mellom 80 og 100 000 lever med demens i Norge og forekomsten vil øke med økende antall eldre. Redusert hukommelse og svekket kognitiv funksjon kan føre til at personer med demens får problemer med å uttrykke seg ... -
Usability and Acceptability of an App (SELFBACK) to Support Self-Management of Low Back Pain: Mixed Methods Study
(Peer reviewed; Journal article, 2020)Background: Self-management is the key recommendation for managing nonspecific low back pain (LBP). However, there are well-documented barriers to self-management; therefore, methods of facilitating adherence are required. ... -
Usability Evaluation of the Preoperative ISBAR (Identification, Situation, Background, Assessment, and Recommendation) Desktop Virtual Reality Application: Qualitative Observational Study
(Journal article; Peer reviewed, 2022)Background: Systematic communication, such as the ISBAR (identification, situation, background, assessment, recommendation) approach, comprises a generic, transferable nontechnical skill. It can be used during the handover ... -
Usability of the IDDEAS prototype in child and adolescent mental health services: A qualitative study for clinical decision support system development
(Peer reviewed; Journal article, 2023)Introduction: Child and adolescent mental health services (CAMHS) clinical decision support system (CDSS) provides clinicians with real-time support as they assess and treat patients. CDSS can integrate diverse clinical ...