Browsing Institutt for datateknologi og informatikk by Author "Olsen, Lene Christin"
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Basal level of autophagy and MAP1LC3B-II as potential biomarkers for DHA-induced cytotoxicity in colorectal cancer cells
Samdal, Helle; Sandmoe, Malin Alise; Olsen, Lene Christin; Jarallah, Elaf Ali Hadi; Høiem, Therese Stork; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild (Journal article, 2018)The omega‐3 fatty acid docosahexaenoic acid (DHA) is known as an anticancer agent. Colorectal cancer (CRC) cells exhibit different sensitivity toward DHA, but the mechanisms involved are still unclear. Gene expression ... -
Establishment of a patient-derived xenograft model of colorectal cancer in CIEA NOG mice and exploring smartfish liquid diet as a source of omega-3 fatty acids
Samdal, Helle; Olsen, Lene Christin; Grøn, Knut Sverre; Røyset, Elin Synnøve; Høiem, Therese Stork; Nervik, Ingunn; Sætrom, Pål; Wibe, Arne; Schønberg, Svanhild Margrethe Arentz; Pettersen, Caroline Hild (Peer reviewed; Journal article, 2021)Cancer patient-derived xenografts (PDXs) better preserve tumor characteristics and microenvironment than traditional cancer cell line derived xenografts and are becoming a valuable model in translational cancer research ... -
Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferation
Hegre, Siv Anita; Samdal, Helle; Klima, Antonin; Stovner, Endre Bakken; Nørsett, Kristin Gabestad; Liabakk, Nina-Beate; Olsen, Lene Christin; Chawla, Konika; Aas, Per Arne; Sætrom, Pål (Peer reviewed; Journal article, 2021)Proper regulation of the cell cycle is necessary for normal growth and development of all organisms. Conversely, altered cell cycle regulation often underlies proliferative diseases such as cancer. Long non-coding RNAs ... -
MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity
Solvin, Åshild Øksnevad; Chawla, Konika; Olsen, Lene Christin; Hegre, Siv Anita; Danielsen, Kjersti; Jenssen, Marita; Furberg, Anne-Sofie; Saunes, Marit; Hveem, Kristian; Sætrom, Pål; Løset, Mari (Peer reviewed; Journal article, 2021)MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize ... -
MicroRNAs contribute to postnatal development of laminar differences and neuronal subtypes in the rat medial entorhinal cortex
Olsen, Lene Christin; O'Reilly, Kally; Liabakk, Nina-Beate; Witter, Menno; Sætrom, Pål (Journal article; Peer reviewed, 2017)The medial entorhinal cortex (MEC) is important in spatial navigation and memory formation and its layers have distinct neuronal subtypes, connectivity, spatial properties, and disease susceptibility. As little is known ... -
Pathway Analysis of Skin from Psoriasis Patients after Adalimumab Treatment Reveals New Early Events in the Anti-Inflammatory Mechanism of Anti-TNF-α
Langkilde, Ane; Olsen, Lene Christin; Sætrom, Pål; Drabløs, Finn Sverre; Besenbacher, Søren; Raaby, Line; Johansen, Claus; Iversen, Lars (Peer reviewed; Journal article, 2016)Psoriasis is a chronic cutaneous inflammatory disease. The immunopathogenesis is a complex interplay between T cells, dendritic cells and the epidermis in which T cells and dendritic cells maintain skin inflammation. ...