Blar i Fakultet for informasjonsteknologi og elektroteknikk (IE) på emneord "Type 1 diabetes"
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The Artificial Pancreas: Two Alternative Approaches to Achieve a Fully Closed Loop System with Optimal Glucose Control
(Peer reviewed; Journal article, 2023)Introduction Diabetes mellitus type 1 is a chronic disease that implies mandatory external insulin delivery. The patients must monitor their blood glucose levels and administer appropriate insulin boluses to keep their ... -
Blood Glucose Level Prediction Using Subcutaneous Sensors for in Vivo Study: Compensation for Measurement Method Slow Dynamics Using a Kalman Filter Approach
(Chapter, 2022)The continuous glucose monitoring (CGM) system is the most common system used by people with type 1 diabetes to monitor blood glucose levels. However, it measures glucose in interstitial fluid in subcutaneous tissue rather ... -
Connecting sensitivity, identifiability and interpretability of a glucose minimal model
(Chapter, 2024)Mathematical models have increased their applications in physiology, control and systems science, and biomedical engineering because they offer the opportunity to examine the structure and behavior of complex physiological ... -
Estimation and Prediction of Glucose Appearance Rate for Use in a Fully Closed-Loop Dual-Hormone Intraperitoneal Artificial Pancreas
(Peer reviewed; Journal article, 2023)Objective: A fully automated artificial pancreas requires a meal estimator and predictions of blood glucose levels (BGL) to handle disturbances during meal times, all without relying on manual meal announcements and user ... -
Feasibility of early meal detection based on abdominal sound.
(Journal article; Peer reviewed, 2019)Background In classical approaches for an artificial pancreas, continuous glucose monitoring (CGM) is the only measured variable used for insulin dosing and additional control functions. The CGM values are subject to time ... -
Feasibility of Meal Onset Detection Using Electrocardiograms
(Chapter, 2024) -
Fully Automated Bi-Hormonal Intraperitoneal Artificial Pancreas Using a Two-Layer PID Control Scheme
(Chapter, 2023)Treatment of type 1 diabetes mellitus is significantly improved by using commercially available hybrid closed-loop systems to deliver insulin. These systems, also called artificial pancreas (AP), use the subcutaneous (SC) ... -
Identifiable Prediction Animal Model for the Bi-Hormonal Intraperitoneal Artificial Pancreas
(Peer reviewed; Journal article, 2022)To achieve a fully automatic artificial pancreas (AP), i.e., an AP without the need for meal announcements, the intraperitoneal (IP) route is explored. This route has faster dynamics than the typical subcutaneous (SC) ... -
Intraperitoneal insulin administration in pigs: Effect on circulating insulin and glucose levels
(Peer reviewed; Journal article, 2021)Introduction The effect of intraperitoneal insulin infusion has limited evidence in the literature. Therefore, the aim of the study was to investigate the pharmacokinetics and pharmacodynamics of different intraperitoneal ... -
Modelling and simulation of occlusions in insulin pumps
(Chapter, 2021)Abstract — An open source simulation model of the mechanical properties of a fully functional insulin pump was made in Matlab Simscape. The model simulates realistic behavior of an insulin pump, parts of which are validated ... -
Pattern recognition reveals characteristic postprandial glucose changes: Non-individualized meal detection in diabetes mellitus type 1
(Journal article; Peer reviewed, 2019)Accurate continuous glucose monitoring (CGM) is essential for fully automated glucose control in diabetes mellitus type 1. State-of-the-art glucose control systems automatically regulate the basal insulin infusion. Users ... -
Simple Nonlinear Models for Glucose-Insulin Dynamics: Application to Intraperitoneal Insulin Infusion
(Journal article; Peer reviewed, 2019)The design of a model-based control method for an Artificial Pancreas requires a relatively simple and identifiable mathematical model to control glucose levels through hormone delivery. In this work we introduce new, ... -
Why intraperitoneal glucose sensing is sometimes surprisingly rapid and sometimes slow: A hypothesis
(Journal article; Peer reviewed, 2019)The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same ...