Browsing Institutt for kjemi by Author "Olsen, Cecilie Elisabeth"
Now showing items 1-6 of 6
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Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Amination of N-protected pyrrolo[2,3-d]pyrimidines and complications with 5-iododerivatives
Rudolfsen, Madelen (Master thesis, 2023)Brystkreft er den vanligste kreftformen, og forekomsten av sykdommen er økende på verdensbasis. Proteinet human epidermal vekstfaktorreseptor 2 (HER2) blir overprodusert i flere av brystkrefttilfellene. Derfor er HER2 et ... -
Anilines in acid catalyzed amination with 4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Svergja, Hanne (Master thesis, 2023)Pyrrolopyrimidiner har en omfattende farmakologisk profil og er av stor betydning i mange biologisk aktive forbindelser. Syre-katalysert aminering av slike heterosykliske forbindelser er en velkjent strategi innen syntese ... -
Halogenated Pyrrolopyrimidines with Low MIC on Staphylococcus aureus and Synergistic Effects with an Antimicrobial Peptide
Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Søgaard, Caroline Krogh; Røst, Lise Marie; Singleton, Amanda; Bergum, Olaug Elisabeth Torheim; Bruheim, Per; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2022)Currently, there is a world-wide rise in antibiotic resistance causing burdens to individuals and public healthcare systems. At the same time drug development is lagging behind. Therefore, finding new ways of treating ... -
Synthesis of aniline substituted heterocycles: searching for anticancer agents
Bathen, Mina (Master thesis, 2022)Abstract will be available on 2024-07-01 -
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
Blindheim, Fredrik Heen; Olsen, Cecilie Elisabeth; Søgaard, Caroline Krogh; Otterlei, Marit; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2021)Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ...