Browsing Institutt for kjemi by Title
Now showing items 1180-1199 of 1359
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Synthesis of steroid analogs as potential CDK8 inhibitors using (S)-hydroxyalkyl azide in a stereoselective ring expansion
(Master thesis, 2021)CDK8 har en viktig rolle i regulering av celletranskripsjon gjennom enzymets tilknytning til mediatorkomplekset eller ved fosforylering av transkripsjonsfaktorer. CDK8-mediert aktivering av onkogener har vist seg å være ... -
Synthesis of Thieno[2,3-d]pyrimidine-Based EGFR-TK Inhibitors with Improved Solubility and Metabolic Stability
(Master thesis, 2015)The objective of this master s thesis was to synthesize EGFR tyrosine kinase inhibitors with enhanced aqueous solubility, metabolic stability and potency compared with commercially available inhibitors. Improving these ... -
Synthesis of Thymidylate Kinase Inhibitor Precursors
(Master thesis, 2019)Multimedikamentresistente bakterier er en av de største helseutfordringene verden står oven- for i dag, noe som gjør forskning og utvikling av ny antibiotika viktigere enn noen sinne. Hemming av et av nøkkelenzymene i ... -
Synthesis studies towards potential therapeutic agents against multiple myeloma (blood cancer)
(Master thesis, 2009) -
Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions
(Journal article; Peer reviewed, 2018)We report the synthesis and properties of temperature- and pH-responsive p([NIPAm-co-PEGMA] (core)/[NIPAm-co-AAc] (shell)) nanogels with narrow size distributions, tunable sizes and increased drug loading efficiencies. The ... -
Synthesis, identification, chiral separation and crystal structure of (3R,4R,7S,8S)-3,4,7,8-tetrachlorodecane and its stereoisomers
(Peer reviewed; Journal article, 2023)Chlorinated paraffins (CPs) are a notoriously known class of compounds that stand amongst the most wide-spread persistent organic pollutants. Therefore, their reliable, repeatable, and reproducible quantitative analysis ... -
Synthesis, Morphological and Photophysical Characterization of Squaraine Based Chromophores
(Master thesis, 2019)I dette studiet har squaraine-kinolin kromoforer blitt undersøkt mot deres fotofysiske, elektrokjemiske og morfologiske egenskaper. Effekten av forskjellige alkylkjeder på stoffenes adferd ble undersøkt ved bruk av absorpsjon ... -
Synthetic Applications of Nitropyridine Derivatives
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:238, Doctoral thesis, 2010)The present work represents a continuation of the investigation of the chemistry of nitropyridine derivatives, based on the methodology for nitration of pyridines developed by Professor Jan M. Bakke and co-workers at NTNU. ... -
Synthetic Efforts to Investigate Structure-Property Relationships in Dyes for Dye- Sensitized Solar Cells
(Doctoral theses at NTNU;2022:300, Doctoral thesis, 2022)With the backdrop of human-induced global warming in mind, the need for sustainable energy has never been larger. The Intergovernmental Panel on Climate Change presented in their recent assessment report that global warming ... -
Synthetic Efforts to Investigate the Effect of Planarizing the Triarylamine Geometry in Dyes for Dye-Sensitized Solar Cells
(Peer reviewed; Journal article, 2022)The geometry of a dye for dye-sensitized solar cells (DSSCs) has a major impact on its optical and electronic properties. The dye structure also dictates the packing properties and how well the dye insulates the metal–oxide ... -
Synthetic exploration towards total synthesis of Fusolanone B
(Master thesis, 2021)γ-pyronet Fusolanone B (28), tidligere isolert av sopp, har vist potensiale som mulig antibiotika. I dette prosjektet er en retrosyntese inspirert av biosyntese av polyketider blitt utført, og to ulike reaksjonsveier har ... -
Synthetic strategies towards 4,6-disubstituted pyrrolo[2,3-d]pyrimidines as potential CSF-1R inhibitors
(Master thesis, 2019)Målet med denne masteroppgaven var å syntetisere nye 4,6-disubstituerte pyrrolo[2,3-d]pyrimidiner som hemmere for CSF-1R (”colony stimulating factor 1 receptor”) tyrosinkinase. En ny strategi for syntese av disse er også ... -
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
(Peer reviewed; Journal article, 2021)Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ... -
Synthetic Strategies Towards Substituted Purines and Their CSF1R Activity
(Master thesis, 2018)Overexpression of colony stimulating factor 1 (CF1R) has been implicated in a number of disease states, such as cancer, inflammatory disorders and bone disease. Inhibition of the colony stimulating factor 1 receptor kinase ... -
Synthetic Strategies Towards Substituted Pyrrolopyridines as Possible CSF1R Inhibitors
(Master thesis, 2017) -
Synthetic Studies Toward a chemical library of Piperine analogs
(Master thesis, 2022)Kalium 5-hydroksypenta-2,4-dienalsalt ble fremstilt basert på litteraturprosedyrene. Dette fungerer som det første utgangsmaterialet i fem-karbon homologeringsprosessen og amideringsreaksjonene for å gi henholdsvis dienal- ... -
Synthetic Studies Toward Dysoxylactam A
(Master thesis, 2021)Naturproduktet dysoxylactam A (1) ble isolert fra barken av Dysoxylum Hongkongense i 2019 og ble funnet til å være en potent inhibitor av P-gp i kreftceller. Målet for dette master prosjektet var å utvikle en ny tilnærming ... -
Synthetic Studies toward Gold(I)-catalyzed preparation of Trifluoromethyl Compounds
(Master thesis, 2015)In this project gold(I)-catalyzed reactions on triple bonds has been investigated, with the trifluoromethyl group incorporated. Initially the goal was to develop a new gold(I)-catalyzed trifluoromethylation reaction, as ... -
A systematic non-equilibrium thermodynamics approach for assessing transport mechanisms in membrane distillation
(Peer reviewed; Journal article, 2023)Membrane distillation (MD) is a promising technique for purifying volatile liquids at temperatures below their boiling points. This study presents a systematic non-equilibrium thermodynamics (NET) approach for analysis of ...