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Synthesis of Small 1,2,3-Triazoles for Antimicrobial Evaluation
(Master thesis, 2018)Antibiotic resistance is an increasing problem globally. Overuse exposes bacteria to different kinds of antibiotics, to which they in time become resistant to. It is therefore important to develop novel antimicrobial ... -
Synthesis of Small Cationic Amphiphiles for Antimicrobial Screening - Transition Metal Catalysed, Microwave-Mediated Indane Synthesis, and Subsequent Functionalisation
(Master thesis, 2017)Infectious diseases are a leading cause of death worldwide and account for more than 13 million deaths annually.[1] A growing ratio of these casualties can be attributed to antimicrobial resistance (AMR). In order to combat ... -
Synthesis of Small Cationic Amphiphiles for Antimicrobial Screening - Transition Metal Catalyzed Benzene Synthesis and Subsequent Functionalization
(Master thesis, 2016)The goal of this project has been to synthesize small cationic amphiphiles with bulky aromatic substituents on a benzene scaffold, for antimicrobial screening. The aromatic and cationic substituents were chosen based on ... -
Synthesis of Small Cationic Amphiphiles for Antimicrobial Screening - Transition Metal Catalyzed Pyridine Synthesis and Subsequent Functionalization
(Master thesis, 2016)The objective of the present thesis has been the synthesis of small cationic peptidomimetics based on a pharmacophore model devloped by Strøm et al. The peptedomimetics were synthesized by functionalization of substituted ... -
Synthesis of stable isotope labelled cathinone derivatives as internal standards for forensic and pharmaceutical analysis.
(Master thesis, 2016)The synthetic work presented in this thesis has focused on identifying efficient routes towards stable isotope labelled cathinone derivatives. These compounds will act as internal standards for forensic and pharmaceutical ... -
Synthesis of steroid analogs as potential CDK8 inhibitors using (S)-hydroxyalkyl azide in a stereoselective ring expansion
(Master thesis, 2021)CDK8 har en viktig rolle i regulering av celletranskripsjon gjennom enzymets tilknytning til mediatorkomplekset eller ved fosforylering av transkripsjonsfaktorer. CDK8-mediert aktivering av onkogener har vist seg å være ... -
Synthesis of Thieno[2,3-d]pyrimidine-Based EGFR-TK Inhibitors with Improved Solubility and Metabolic Stability
(Master thesis, 2015)The objective of this master s thesis was to synthesize EGFR tyrosine kinase inhibitors with enhanced aqueous solubility, metabolic stability and potency compared with commercially available inhibitors. Improving these ... -
Synthesis of Thymidylate Kinase Inhibitor Precursors
(Master thesis, 2019)Multimedikamentresistente bakterier er en av de største helseutfordringene verden står oven- for i dag, noe som gjør forskning og utvikling av ny antibiotika viktigere enn noen sinne. Hemming av et av nøkkelenzymene i ... -
Synthesis studies towards potential therapeutic agents against multiple myeloma (blood cancer)
(Master thesis, 2009) -
Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions
(Journal article; Peer reviewed, 2018)We report the synthesis and properties of temperature- and pH-responsive p([NIPAm-co-PEGMA] (core)/[NIPAm-co-AAc] (shell)) nanogels with narrow size distributions, tunable sizes and increased drug loading efficiencies. The ... -
Synthesis, crystal structure and biological evaluation of N,N’-disubstituted guanidines
(Master thesis, 2024)Som del av et større forskningsprosjekt, var et av hovedmålene for denne masteroppgaven å syntetisere nye analoger av et «hit» stoff, med mål om å inhibere DNA glykosylasen NEIL2. Med bakgrunn i dette ble 17 N,N’-disubstituerte ... -
Synthesis, identification, chiral separation and crystal structure of (3R,4R,7S,8S)-3,4,7,8-tetrachlorodecane and its stereoisomers
(Peer reviewed; Journal article, 2023)Chlorinated paraffins (CPs) are a notoriously known class of compounds that stand amongst the most wide-spread persistent organic pollutants. Therefore, their reliable, repeatable, and reproducible quantitative analysis ... -
Synthesis, Morphological and Photophysical Characterization of Squaraine Based Chromophores
(Master thesis, 2019)I dette studiet har squaraine-kinolin kromoforer blitt undersøkt mot deres fotofysiske, elektrokjemiske og morfologiske egenskaper. Effekten av forskjellige alkylkjeder på stoffenes adferd ble undersøkt ved bruk av absorpsjon ... -
Synthetic Applications of Nitropyridine Derivatives
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:238, Doctoral thesis, 2010)The present work represents a continuation of the investigation of the chemistry of nitropyridine derivatives, based on the methodology for nitration of pyridines developed by Professor Jan M. Bakke and co-workers at NTNU. ... -
Synthetic Efforts to Investigate Structure-Property Relationships in Dyes for Dye- Sensitized Solar Cells
(Doctoral theses at NTNU;2022:300, Doctoral thesis, 2022)With the backdrop of human-induced global warming in mind, the need for sustainable energy has never been larger. The Intergovernmental Panel on Climate Change presented in their recent assessment report that global warming ... -
Synthetic Efforts to Investigate the Effect of Planarizing the Triarylamine Geometry in Dyes for Dye-Sensitized Solar Cells
(Peer reviewed; Journal article, 2022)The geometry of a dye for dye-sensitized solar cells (DSSCs) has a major impact on its optical and electronic properties. The dye structure also dictates the packing properties and how well the dye insulates the metal–oxide ... -
Synthetic exploration towards total synthesis of Fusolanone B
(Master thesis, 2021)γ-pyronet Fusolanone B (28), tidligere isolert av sopp, har vist potensiale som mulig antibiotika. I dette prosjektet er en retrosyntese inspirert av biosyntese av polyketider blitt utført, og to ulike reaksjonsveier har ... -
Synthetic strategies towards 4,6-disubstituted pyrrolo[2,3-d]pyrimidines as potential CSF-1R inhibitors
(Master thesis, 2019)Målet med denne masteroppgaven var å syntetisere nye 4,6-disubstituerte pyrrolo[2,3-d]pyrimidiner som hemmere for CSF-1R (”colony stimulating factor 1 receptor”) tyrosinkinase. En ny strategi for syntese av disse er også ... -
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
(Peer reviewed; Journal article, 2021)Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ...