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Synthesis, Characterization and Drug Loading of Multiresponsive p[NIPAm-co-PEGMA] (core)/p[NIPAm-co-AAc] (Shell) Nanogels with Monodisperse Size Distributions
(Journal article; Peer reviewed, 2018)We report the synthesis and properties of temperature- and pH-responsive p([NIPAm-co-PEGMA] (core)/[NIPAm-co-AAc] (shell)) nanogels with narrow size distributions, tunable sizes and increased drug loading efficiencies. The ... -
Synthesis, crystal structure and biological evaluation of N,N’-disubstituted guanidines
(Master thesis, 2024)Som del av et større forskningsprosjekt, var et av hovedmålene for denne masteroppgaven å syntetisere nye analoger av et «hit» stoff, med mål om å inhibere DNA glykosylasen NEIL2. Med bakgrunn i dette ble 17 N,N’-disubstituerte ... -
Synthesis, identification, chiral separation and crystal structure of (3R,4R,7S,8S)-3,4,7,8-tetrachlorodecane and its stereoisomers
(Peer reviewed; Journal article, 2023)Chlorinated paraffins (CPs) are a notoriously known class of compounds that stand amongst the most wide-spread persistent organic pollutants. Therefore, their reliable, repeatable, and reproducible quantitative analysis ... -
Synthesis, Morphological and Photophysical Characterization of Squaraine Based Chromophores
(Master thesis, 2019)I dette studiet har squaraine-kinolin kromoforer blitt undersøkt mot deres fotofysiske, elektrokjemiske og morfologiske egenskaper. Effekten av forskjellige alkylkjeder på stoffenes adferd ble undersøkt ved bruk av absorpsjon ... -
Synthetic Applications of Nitropyridine Derivatives
(Doktoravhandlinger ved NTNU, 1503-8181; 2010:238, Doctoral thesis, 2010)The present work represents a continuation of the investigation of the chemistry of nitropyridine derivatives, based on the methodology for nitration of pyridines developed by Professor Jan M. Bakke and co-workers at NTNU. ... -
Synthetic Efforts to Investigate Structure-Property Relationships in Dyes for Dye- Sensitized Solar Cells
(Doctoral theses at NTNU;2022:300, Doctoral thesis, 2022)With the backdrop of human-induced global warming in mind, the need for sustainable energy has never been larger. The Intergovernmental Panel on Climate Change presented in their recent assessment report that global warming ... -
Synthetic Efforts to Investigate the Effect of Planarizing the Triarylamine Geometry in Dyes for Dye-Sensitized Solar Cells
(Peer reviewed; Journal article, 2022)The geometry of a dye for dye-sensitized solar cells (DSSCs) has a major impact on its optical and electronic properties. The dye structure also dictates the packing properties and how well the dye insulates the metal–oxide ... -
Synthetic exploration towards total synthesis of Fusolanone B
(Master thesis, 2021)γ-pyronet Fusolanone B (28), tidligere isolert av sopp, har vist potensiale som mulig antibiotika. I dette prosjektet er en retrosyntese inspirert av biosyntese av polyketider blitt utført, og to ulike reaksjonsveier har ... -
Synthetic strategies towards 4,6-disubstituted pyrrolo[2,3-d]pyrimidines as potential CSF-1R inhibitors
(Master thesis, 2019)Målet med denne masteroppgaven var å syntetisere nye 4,6-disubstituerte pyrrolo[2,3-d]pyrimidiner som hemmere for CSF-1R (”colony stimulating factor 1 receptor”) tyrosinkinase. En ny strategi for syntese av disse er også ... -
Synthetic Strategies towards Imidazopyridinones and 7-Azaoxindoles and their Evaluation as Antibacterial Agents
(Peer reviewed; Journal article, 2021)Imidazopyridinones and 7-azaoxindoles are two classes of heterocyclic compounds with only limited previous use in organic and medicinal chemistry. Various synthetic methods and routes have been evaluated to identify safe ... -
Synthetic Strategies Towards Substituted Purines and Their CSF1R Activity
(Master thesis, 2018)Overexpression of colony stimulating factor 1 (CF1R) has been implicated in a number of disease states, such as cancer, inflammatory disorders and bone disease. Inhibition of the colony stimulating factor 1 receptor kinase ... -
Synthetic Strategies Towards Substituted Pyrrolopyridines as Possible CSF1R Inhibitors
(Master thesis, 2017) -
Synthetic Studies Toward a chemical library of Piperine analogs
(Master thesis, 2022)Kalium 5-hydroksypenta-2,4-dienalsalt ble fremstilt basert på litteraturprosedyrene. Dette fungerer som det første utgangsmaterialet i fem-karbon homologeringsprosessen og amideringsreaksjonene for å gi henholdsvis dienal- ... -
Synthetic Studies Toward Dysoxylactam A
(Master thesis, 2021)Naturproduktet dysoxylactam A (1) ble isolert fra barken av Dysoxylum Hongkongense i 2019 og ble funnet til å være en potent inhibitor av P-gp i kreftceller. Målet for dette master prosjektet var å utvikle en ny tilnærming ... -
Synthetic Studies toward Gold(I)-catalyzed preparation of Trifluoromethyl Compounds
(Master thesis, 2015)In this project gold(I)-catalyzed reactions on triple bonds has been investigated, with the trifluoromethyl group incorporated. Initially the goal was to develop a new gold(I)-catalyzed trifluoromethylation reaction, as ... -
A systematic non-equilibrium thermodynamics approach for assessing transport mechanisms in membrane distillation
(Peer reviewed; Journal article, 2023)Membrane distillation (MD) is a promising technique for purifying volatile liquids at temperatures below their boiling points. This study presents a systematic non-equilibrium thermodynamics (NET) approach for analysis of ... -
Tailored Porosities of the Cathode Layer for Improved Polymer Electrolyte Fuel Cell Performance
(Journal article; Peer reviewed, 2015)We show experimentally for the fi rst time that the introduction of macro-pores in the nanoporous catalyst layer of a polymer electrolyte membrane fuel cell can improve its performance. We have ach- ieved a Pt utilization ... -
TD-DFT based fine-tuning of molecular excitation energies using evolutionary algorithms
(Journal article; Peer reviewed, 2016)An evolutionary de novo design method is presented to fine-tune the excitation energies of molecules calculated using time-dependent density functional theory (TD-DFT). The approach is applied to a π-conjugated molecular ... -
Teaching complex molecular simulation algorithms: Using self‐evaluation to tailor web‐based exercises at an individual level
(Peer reviewed; Journal article, 2020)It is quite challenging to learn complex mathematical algorithms used in molecular simulations, stressing the importance of using the most advantageous teaching methods. Ideally, individuals should learn at their pace and ...