• A 4-year follow-up of patients with medication-overuse headache previously included in a randomized multicentre study 

      Hagen, Knut; Albretsen, Claus; Vilming, Steinar; Salvesen, Rolf; Grønning, Marit; Helde, Grethe; Gravdahl, Gøril Bruvik; Zwart, John-Anker; Stovner, Lars Jacob (Journal article; Peer reviewed, 2011)
    • A Comparison of Anthropometric Measures for Assessing the Association between Body Size and Risk of Chronic Low Back Pain: TheHUNT Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article, 2015)
      Background: Previous work indicates that overweight and obese individuals carry an increased risk of experiencing chronic low back pain (LBP). It is not known, however, how the association with body size depends on the ...
    • A tonic heat test stimulus yields a larger and more reliable conditioned pain modulation effect compared to a phasic heat test stimulus 

      Lie, Marie; Matre, Dagfinn; Hansson, Per; Stubhaug, Audun; Zwart, John-Anker; Nilsen, Kristian Bernhard (Journal article; Peer reviewed, 2017)
      Introduction: The interest in conditioned pain modulation (CPM) as a clinical tool for measuring endogenously induced analgesia is increasing. There is, however, large variation in the CPM methodology, hindering comparison ...
    • Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register) 

      Hellevik, Alf Inge; Nordsletten, Lars; Johnsen, Marianne Bakke; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Langhammer, Arnulf (Journal article; Peer reviewed, 2017)
      Objective To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) ...
    • Anxiety, depression and behavioral problems among adolescents with recurrent headache: the Young-HUNT study 

      Blaauw, Brit Andenes; Dyb, Grete; Hagen, Knut; Holmen, Turid Lingaas; Linde, Mattias; Wentzel-Larsen, Tore; Zwart, John-Anker (Journal article; Peer reviewed, 2014)
      Background It is well documented that both anxiety and depression are associated with headache, but there is limited knowledge regarding the relation between recurrent primary headaches and symptoms of anxiety and ...
    • Association between blood pressure measures and recurrent headache in adolescents: cross-sectional data from the HUNT-Youth study 

      Tronvik, Erling; Zwart, John-Anker; Hagen, Knut; Dyb, Grete; Holmen, Turid Lingaas; Stovner, Lars Jacob (Journal article; Peer reviewed, 2011)
      The relationship between blood pressure and headache in youth has not been explored and the objective of the present study was to provide data on this association in an adolescent population. Cross-sectional data from a ...
    • Association between body height and chronic low back pain: a follow-up in the Nord-Trøndelag Health Study. 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article; Peer reviewed, 2015)
      Objective To study potential associations between body height and subsequent occurrence of chronic low back pain (LBP). Design Prospective cohort study. Setting The North-Trøndelag Health Study (HUNT). Data ...
    • The association between insomnia, c-reactive protein, and chronic low back pain: Cross-sectional analysis of the HUNT study, Norway 

      Ho, Kevin Kwan Ngai; Simic, Milena; Småstuen, Milada Cvancarova; de Barros Pinheiro, Marina; Ferreira, Paulo Herrique; Johnsen, Marianne Bakke; Heuch, Ingrid; Grotle, Margreth; Zwart, John-Anker; Nilsen, Kristian Bernhard (Peer reviewed; Journal article, 2019)
      Chronic low back pain (chronic LBP) is the number one cause for years lived with disability among 301 diseases and injuries analyzed by The Global Burden of Disease study 2013. Insomnia is highly prevalent among people ...
    • Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use 

      Liu, Ming; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M.; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; Mitchell, Amy; Skogholt, Anne Heidi; Sivertsen, Børge; Stordal, Eystein; Morken, Gunnar; Kallestad, Håvard; Heuch, Ingrid; Zwart, John-Anker; Fjukstad, Katrine Kveli; Pedersen, Linda Margareth; Johnsen, Marianne Bakke; Skrove, Marit Synnøve; Indredavik, Marit Sæbø; Drange, Ole Kristian; Bjerkeset, Ottar; Børte, Sigrid; Stensland, Synne; Choquet, Hélène; Docherty, Anna R.; Faul, Jessica D.; Foerster, Johanna R.; Fritsche, Lars; Gabrielsen, Maiken Elvestad; Gordon, Scott D.; Haessler, Jeffrey; Hottenga, Jouke-Jan; Huang, Hongyan; Jang, Seon-Kyeong; Jansen, Philip R.; Ling, Yueh; Mägi, Reedik; Matoba, Nana; McMahon, George; Mulas, Antonella; Orrú, Valeria; Palviainen, Teemu; Pandit, Anita; Reginsson, Gunnar W.; Smith, Jennifer A.; Taylor, Amy E.; Turman, Constance; Willemsen, Gonneke; Young, Hannah; Young, Kendra A.; Zajac, Gregory J.M.; Zhao, Wei; Zhou, Wei; Björnsdóttir, Gyda Thora; Boardman, Jason D.; Boehnke, Michael; Boomsma, Dorret I.; Chen, Chu; Davies, Gareth E.; Eaton, Charles B.; Winsvold, Bendik K S; Hveem, Kristian; Vrieze, Scott (Journal article; Peer reviewed, 2019)
      Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery ...
    • Biological and Clinical Insights From Genetics of Insomnia Symptoms 

      Lane, Jacqueline M.; Jones, Samuel E.; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Brumpton, Ben Michael; Zwart, John-Anker; Nielsen, Jonas Bille; Winswold, Bendik; Willer, Cristen J; Janszky, Imre; Johnsen, Marianne Bakke; Wood, Andrew R.; Strand, Linn B.; Bowden, Jack; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Beaumont, Robin N.; Bechtold, David A.; Cade, Brian E.; Kathiresan, Sekar; Little, Max A.; Loudon, Andrew S.; Purcell, Shaun; Richmond, Rebecca C.; Schormair, Barbara; Tyrrell, Jessica; Winkelmann, Juliane; Zhao, Cheng; Redline, Susan; Spiegelhalder, Kai; Kyle, Simon D.; Frayling, Timothy M.; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we ...
    • Clinical effect modifiers of antibiotic treatment in patients with chronic low back pain and Modic changes - Secondary analyses of a randomised, placebo-controlled trial (the AIM study) 

      Bråten, Lars Christian Haugli; Grøvle, Lars; Espeland, Ansgar; Pripp, Are Hugo; Grotle, Margreth; Hellum, Christian; Haugen, Anne Julsrud; Froholdt, Anne; Rolfsen, Mads Peder; Nygaard, Øystein Petter; Lutro, Olav; Kristoffersen, Per M; Anke, Audny; Schistad, Ellina Iordanova; Skouen, Jan Sture; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (Peer reviewed; Journal article, 2020)
      Background Randomised trials on antibiotic treatment for patients with chronic low back pain and vertebral endplate changes visible on MRI (Modic changes) have shown mixed results. A possible explanation might be a real ...
    • Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT) 

      Bækken, Petter; Skorpen, Frank; Stordal, Eystein; Zwart, John-Anker; Hagen, Knut (Journal article; Peer reviewed, 2008)
      Background: The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results are not conclusive. The aim of the present ...
    • Do abnormal serum lipid levels increase the risk of chronic low back pain? The Nord-Trøndelag Health Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article; Peer reviewed, 2014)
      Background: Cross-sectional studies suggest associations between abnormal lipid levels and prevalence of low back pain (LBP), but it is not known if there is any causal relationship. Objective: The objective was to ...
    • Do incident musculoskeletal complaints influence mortality? The Nord-Trøndelag Health study 

      Åsberg, Anders Nikolai; Hagen, Knut; Stovner, Lars Jacob; HEUCH, INGRID; Zwart, John-Anker; Winsvold, Bendik K S (Journal article; Peer reviewed, 2018)
      Background Musculoskeletal complaints (MSC) are common in the general population, causing a major disease burden to the individual and society. The association between MSC and mortality is still unclear. To our knowledge, ...
    • Does diabetes influence the probability of experiencing chronic low back pain? A population-based cohort study: the Nord-Trøndelag Health Study 

      Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Sørgjerd, Elin Pettersen; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2019)
      Objective Low back pain (LBP) is a major problem in modern society and it is important to study possible risk factors for this disorder. People with diabetes are often affected by LBP, but whether diabetes represents a ...
    • Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial 

      Bråten, Lars Christian Haugli; Rolfsen, Mads Peder; Espeland, Ansgar; Wigemyr, Monica; Assmus, Jörg; Froholdt, Anne; Haugen, Anne Julsrud; Marchand, Gunn Hege; Kristoffersen, Per M; Lutro, Olav; Randen, Sigrun; Wilhelmsen, Maja; Winsvold, Bendik K S; Kadar, Thomas; Holmgard, Thor Einar; Vigeland, Maria Dehli; Vetti, Nils; Nygaard, Øystein Petter; Lie, Benedicte Alexandra; Hellum, Christian; Anke, Audny; Grotle, Margreth; Schistad, Ellina Iordanova; Skouen, Jan Sture; Grøvle, Lars; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (Journal article; Peer reviewed, 2019)
      Objective To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes). Design Double ...
    • Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes 

      Wang, Heming; Lane, Jacqueline M.; Jones, Samuel E.; Dashti, Hassan S.; Ollila, Hanna M.; Wood, Andrew R.; van Hees, Vincent T.; Brumpton, Ben Michael; Winsvold, Bendik K S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E.; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Bechtold, David A.; Bowden, Jack; Emsley, Richard; Kyle, Simon D.; Little, Max A.; Loudon, Andrew S.; Scheer, Frank A.J.L.; Purcell, Shaun M.; Richmond, Rebecca C.; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A.; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B.; Willer, Cristen J.; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M.; Ray, David; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Redline, Susan; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ...
    • Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts 

      Boraska, V; Day-Williams, A; Franklin, CS; Elliott, KS; Panoutsopoulou, K; Tachmazidou, I; Albrecht, E; Bandinelli, S; Beilin, L; Bochud, M; Cadby, G; Ernst, F; Evans, David M.; Hayward, C; Hicks, AA; Huffman, Jennifer; Huth, C; James, AL; Klopp, N; Kolcic, I; Kutalik, Z; Lawlor, Debbie A.; Musk, AW; Pehlic, M; Pennell, CE; Perry, JRB; Peters, Annette; Polasek, O; St Pourcain, B; Ring, SM; Salvi, E; Schipf, S; Staessen, JA; Teumer, A; Timpson, N; Vitart, V; Warrington, NM; Yaghootkar, H; Zemunik, T; Zgaga, L; An, P; Anttila, V; Borecki, IB; Holmen, Jostein; Ntalla, I; Palotie, A; Pietilainen, KH; Wedenoja, J; Winsvold, Bendik Kristoffer Slagsvold; Dedoussis, GV; Kaprio, J; Province, MA; Zwart, John-Anker; Burnier, M; Campbell, H; Cusi, D; Smith, GD; Frayling, TM; Gieger, C; Palmer, LJ; Pramstaller, PP; Rudan, I; Volzke, H; Wichmann, HE; Wright, AF; Zeggini, E (Journal article; Peer reviewed, 2012)
      Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric ...
    • Headache and musculoskeletal complaints among subjects with self reported whiplash injury. The HUNT-2 study 

      Myran, Rigmor; Hagen, Knut; Svebak, Sven; Nygaard, Øystein Petter; Zwart, John-Anker (Journal article; Peer reviewed, 2011)
      Background: To evaluate the life-time prevalence of self reported whiplash injury and the relationship to chronic musculoskeletal complaints (MSCs) and headache in a large unselected adult population. Methods: Between ...
    • Headache as a predictor for dementia: The HUNT Study 

      Røttereng, Ane Karoline Stræte; Bosnes, Ole; Stordal, Eystein; Zwart, John-Anker; Linde, Mattias; Stovner, Lars Jacob; Hagen, Knut (Journal article; Peer reviewed, 2015)
      Background: The impact of headache on dementia is largely unknown. This study examined the association between headache and dementia using data from a large population-based study. Methods: This population-based study ...