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Depression and anxiety in relation to catechol-O-methyltransferase Val158Met genotype in the general population: The Nord-Trøndelag Health Study (HUNT)

Bækken, Petter; Skorpen, Frank; Stordal, Eystein; Zwart, John-Anker; Hagen, Knut
Journal article, Peer reviewed
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URI
http://hdl.handle.net/11250/332229
Date
2008
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  • Fakultet for medisin og helsevitenskap (uspesifisert) [213]
  • Institutt for nevromedisin og bevegelsesvitenskap [1643]
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Original version
BMC Psychiatry 2008, 8(25):48   10.1186/1471-244X-8-48
Abstract
Background: The catechol-O-methyltransferase (COMT) gene contains a functional

polymorphism, Val158Met, which has been linked to anxiety and depression, but previous results

are not conclusive. The aim of the present study was to examine the relationship between the

Val158Met COMT gene polymorphism and anxiety and depression measured by the Hospital

Anxiety and Depression Scale (HADS) in the general adult population.

Methods: In the Nord-Trøndelag Health Study (HUNT) the association between the Val158Met

polymorphism and anxiety and depression was evaluated in a random sample of 5531 individuals.

Two different cut off scores (≥ 8 and ≥ 11) were used to identify cases with anxiety (HADS-A) and

depression (HADS-D), whereas controls had HADS-A <8 and HADS-D <8.

Results: The COMT genotype distribution was similar between controls and individuals in the

groups with anxiety and depression using cut-off scores of ≥ 8. When utilizing the alternative cutoff

score HADS-D ≥ 11, Met/Met genotype and Met allele were less common among men with

depression compared to the controls (genotype: p = 0.017, allele: p = 0.006). In the multivariate

analysis, adjusting for age and heart disease, depression (HADS-D ≥ 11) was less likely among men

with the Met/Met genotype than among men with the Val/Val genotype (OR = 0.37, 95% CI =

0.18–0.76).

Conclusion: In this population-based study, no clear association between the Val158Met

polymorphism and depression and anxiety was revealed. The Met/Met genotype was less likely

among men with depression defined as HADS-D ≥ 11, but this may be an incidental finding.
Publisher
BioMed Central
Journal
BMC Psychiatry

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