Blar i NTNU Open på forfatter "Zwart, John-Anker"
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The effect of infliximab in patients with chronic low back pain and Modic changes (the BackToBasic study): study protocol of a randomized, double blind, placebo-controlled, multicenter trial
Gjefsen, Elisabeth; Bråten, Lars Christian Haugli; Goll, Guro Løvik; Wigemyr, Monica; Bolstad, Nils; Valberg, Morten; Schistad, Ellina Iordanova; Marchand, Gunn Hege; Granviken, Fredrik; Selmer, Kaja Kristine; Johanessen, Anne Froholdt; Haugen, Anne Julsrud; Dagestad, Magnhild Hammersland; Vetti, Nils; Bakland, Gunnstein; Lie, Benedicte Alexandra; Haavardsholm, Espen A.; Nilsen, Aksel Thuv; Holmgard, Thor Einar; Kadar, Thomas; Kvien, Tore Kristian; Skouen, Jan Sture; Grøvle, Lars; Brox, Jens Ivar; Espeland, Ansgar; Storheim, Kjersti; Zwart, John-Anker (Peer reviewed; Journal article, 2020)Low back pain is common and a significant number of patients experience chronic low back pain. Current treatment options offer small to moderate effects. Patients with vertebral bone marrow lesions visualized as Modic ... -
Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial
Bråten, Lars Christian Haugli; Rolfsen, Mads Peder; Espeland, Ansgar; Wigemyr, Monica; Assmus, Jörg; Froholdt, Anne; Haugen, Anne Julsrud; Marchand, Gunn Hege; Kristoffersen, Per M; Lutro, Olav; Randen, Sigrun; Wilhelmsen, Maja; Winsvold, Bendik K S; Kadar, Thomas; Holmgard, Thor Einar; Vigeland, Maria Dehli; Vetti, Nils; Nygaard, Øystein Petter; Lie, Benedicte Alexandra; Hellum, Christian; Anke, Audny; Grotle, Margreth; Schistad, Ellina Iordanova; Skouen, Jan Sture; Grøvle, Lars; Brox, Jens Ivar; Zwart, John-Anker; Storheim, Kjersti (Journal article; Peer reviewed, 2019)Objective To assess the efficacy of three months of antibiotic treatment compared with placebo in patients with chronic low back pain, previous disc herniation, and vertebral endplate changes (Modic changes). Design Double ... -
Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache
Harder, Aster V.E.; Winsvold, Bendik K S; Noordam, Raymond; Vijfhuizen, Lisanne S.; Børte, Sigrid; Kogelman, Lisette J.A.; de Boer, Irene; Tronvik, Erling Andreas; Rosendaal, Frits; Willems van Dijk, Ko; O'Connor, Emer; Fourier, Carmen; Thomas, Laurent; Kristoffersen, Espen Saxhaug; Fronczek, Rolf; Pozo-Rosich, Patricia; Jensen, Rigmor; Ferrari, Michel D.; Hansen, Thomas; Zwart, John-Anker; Terwindt, Gisela M.; van den Maagdenberg, Arn M.J.M (Peer reviewed; Journal article, 2021)Objective Identifying common genetic variants that confer genetic risk for cluster headache. Methods We conducted a case–control study in the Dutch Leiden University Cluster headache neuro-Analysis program (LUCA) study ... -
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
Wang, Heming; Lane, Jacqueline M.; Jones, Samuel E.; Dashti, Hassan S.; Ollila, Hanna M.; Wood, Andrew R.; van Hees, Vincent T.; Brumpton, Ben Michael; Winsvold, Bendik K S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E.; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Bechtold, David A.; Bowden, Jack; Emsley, Richard; Kyle, Simon D.; Little, Max A.; Loudon, Andrew S.; Scheer, Frank A.J.L.; Purcell, Shaun M.; Richmond, Rebecca C.; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A.; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B.; Willer, Cristen J.; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M.; Ray, David; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Redline, Susan; Saxena, Richa (Journal article; Peer reviewed, 2019)Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ... -
Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
Bakker, Mark K.; Spek, Rick A.A. var der; Rheenen, Wouter van; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C.; Varinder, S. Alg; Eijk, Kristel R. van; Koido, Masaru; Akiyama, Masato; Terao, Chikashi; Matsuda, Koichi; Walters, Robin G.; Lin, Kuang; Li, Liming; Millwood, Iona Y.; Chen, Zhengming; Rouleau, Guy A.; Zhou, Sirui; Rannikmae, Kristiina; Sudlow, Cathie L.M.; Houlden, Henry; Berg, Leonard H. van den; Dina, Christian; Naggara, Olivier; Gentric, Jean-Christophe; Shotar, Eimad; Eugène, François; Desal, Hubert; Winsvold, Bendik K S; Børte, Sigrid; Johnsen, Marianne Bakke; Brumpton, Ben Michael; Sandvei, Marie Søfteland; Willer, Cristen J.; Hveem, Kristian; Zwart, John-Anker; Verschuren, W.M. Monique; Friedrich, Christoph M.; Hirsch, Sven; Schilling, Sabine; Dauvillier, Jérôme; Martin, Olivier; Jones, Gregory T.; Bown, Matthew J.; Ko, Nerissa U.; Kim, Helen; Coleman, Jonathan R. I.; Breen, Gerome; Zaroff, Jonathan G. (Peer reviewed; Journal article, 2020)Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide ... -
Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts
Boraska, V; Day-Williams, A; Franklin, CS; Elliott, KS; Panoutsopoulou, K; Tachmazidou, I; Albrecht, E; Bandinelli, S; Beilin, L; Bochud, M; Cadby, G; Ernst, F; Evans, David M.; Hayward, C; Hicks, AA; Huffman, Jennifer; Huth, C; James, AL; Klopp, N; Kolcic, I; Kutalik, Z; Lawlor, Debbie A.; Musk, AW; Pehlic, M; Pennell, CE; Perry, JRB; Peters, Annette; Polasek, O; St Pourcain, B; Ring, SM; Salvi, E; Schipf, S; Staessen, JA; Teumer, A; Timpson, N; Vitart, V; Warrington, NM; Yaghootkar, H; Zemunik, T; Zgaga, L; An, P; Anttila, V; Borecki, IB; Holmen, Jostein; Ntalla, I; Palotie, A; Pietilainen, KH; Wedenoja, J; Winsvold, Bendik Kristoffer Slagsvold; Dedoussis, GV; Kaprio, J; Province, MA; Zwart, John-Anker; Burnier, M; Campbell, H; Cusi, D; Smith, GD; Frayling, TM; Gieger, C; Palmer, LJ; Pramstaller, PP; Rudan, I; Volzke, H; Wichmann, HE; Wright, AF; Zeggini, E (Journal article; Peer reviewed, 2012)Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric ... -
Headache and musculoskeletal complaints among subjects with self reported whiplash injury. The HUNT-2 study
Myran, Rigmor; Hagen, Knut; Svebak, Sven; Nygaard, Øystein Petter; Zwart, John-Anker (Journal article; Peer reviewed, 2011)Background: To evaluate the life-time prevalence of self reported whiplash injury and the relationship to chronic musculoskeletal complaints (MSCs) and headache in a large unselected adult population. Methods: Between ... -
Headache as a predictor for dementia: The HUNT Study
Røttereng, Ane Karoline Stræte; Bosnes, Ole; Stordal, Eystein; Zwart, John-Anker; Linde, Mattias; Stovner, Lars Jacob; Hagen, Knut (Journal article; Peer reviewed, 2015)Background: The impact of headache on dementia is largely unknown. This study examined the association between headache and dementia using data from a large population-based study. Methods: This population-based study ... -
High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019
Hagen, Knut; Stovner, Lars Jacob; Zwart, John-Anker (Peer reviewed; Journal article, 2020)Background Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investigate ... -
Impact of technical variations on the ring-finger test for carpal tunnelsyndrome
Schulze, Daniel Gregor; Nordby, Karl-Christian; Småstuen, Milada Cvancarova; Clemm, Thomas; Grotle, Margreth; Zwart, John-Anker; Nilsen, Kristian Bernhard (Journal article; Peer reviewed, 2019)Objective To assess if recording the sensory latencies of the median and ulnar nerves one-by-one (consecutive) or at the same time (simultaneous) in the ring-finger test for carpal tunnel syndrome (CTS) will show equivalent ... -
Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study)
Hellevik, Alf Inge; Johnsen, Marianne Bakke; Langhammer, Arnulf; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Nordsletten, Lars (Journal article; Peer reviewed, 2017)Background To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. Methods In a prospective cohort study, data from the second and third survey of the ... -
Is chronic low back pain a risk factor for diabetes? The Nord-Trøndelag Health Study
HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Sørgjerd, Elin Pettersen; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2018)Objective The purpose of this study was to examine the risk of diabetes associated with the presence or absence of chronic low back pain, considering both cross-sectional and cohort data. Research design and methods ... -
Is there a U-shaped relationship between physical activity in leisure time and risk of chronic low back pain? A follow-up in the HUNT Study
HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article; Peer reviewed, 2016)Background Physical activity in leisure time is often considered to have favourable effects on the risk of low back pain (LBP), but demonstrating a definite association in epidemiological studies has proven difficult. The ... -
Is there an Association between vitamin D status and risk of chronic low bak pain? A nested case-Control analysis in the Nord-Trøndelag Health Study
HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Mai, Xiao-Mei; Langhammer, Arnulf; Zwart, John-Anker (Journal article; Peer reviewed, 2017)Objectives: To explore potential associations between vitamin D status and risk of chronic low back pain (LBP) in a Norwegian cohort, and to investigate whether relationships depend on the season of blood sample collection. ... -
Leisure time physical activity and the risk of hip or knee replacement due to primary osteoarthritis: A population based cohort study (The HUNT Study)
Johnsen, Marianne Bakke; Hellevik, Alf Inge; Baste, Valborg; Furnes, Ove; Langhammer, Arnulf; Flugsrud, Gunnar B; Nordsletten, Lars; Zwart, John-Anker; Storheim, Kjersti (Journal article; Peer reviewed, 2016)Background The relationship between leisure time physical activity (LPA) and hip and knee OA and subsequent joint replacement has not yet been clearly defined. Some studies have found the risk of knee replacement (TKR) to ... -
Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008
Hagen, Knut; Åsberg, Anders Nikolai; Stovner, Lars Jacob; Linde, Mattias; Zwart, John-Anker; Winsvold, Bendik K S; HEUCH, INGRID (Journal article; Peer reviewed, 2018)Aims The aim of this population-based historical cohort study was to investigate the influence of lifestyle factors on the risk of developing migraine or tension-type headache (TTH). Methods Data from the Nord-Trøndelag ... -
Metabolic syndrome as a risk factor for total hip or knee replacement due to primary osteoarthritis: A prospective cohort study (the HUNT study and the Norwegian arthroplasty register)
Hellevik, Alf Inge; Johnsen, Marianne Bakke; Langhammer, Arnulf; Baste, Valborg; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Nordsletten, Lars (Journal article; Peer reviewed, 2018)Objective: Biochemical changes associated with obesity may accelerate osteoarthritis beyond the effect of mechanical factors. This study investigated whether metabolic syndrome and its components (visceral obesity, ... -
Migraine, obesity and body fat distribution - a population-based study
Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)Background: Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship between ... -
Mitochondrial genome-wide association study of migraine – the HUNT Study
Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars G; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ... -
No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT Study
Hagen, Knut; Pettersen, Elin; Stovner, Lars Jacob; Skorpen, Frank; Zwart, John-Anker (Journal article; Peer reviewed, 2006-05-04)Background: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with ...