Now showing items 21-40 of 54

    • Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes 

      Wang, Heming; Lane, Jacqueline M.; Jones, Samuel E.; Dashti, Hassan S.; Ollila, Hanna M.; Wood, Andrew R.; van Hees, Vincent T.; Brumpton, Ben Michael; Winsvold, Bendik K S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E.; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Bechtold, David A.; Bowden, Jack; Emsley, Richard; Kyle, Simon D.; Little, Max A.; Loudon, Andrew S.; Scheer, Frank A.J.L.; Purcell, Shaun M.; Richmond, Rebecca C.; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A.; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B.; Willer, Cristen J.; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M.; Ray, David; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Redline, Susan; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ...
    • Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors 

      Bakker, Mark K.; Spek, Rick A.A. var der; Rheenen, Wouter van; Morel, Sandrine; Bourcier, Romain; Hostettler, Isabel C.; Varinder, S. Alg; Eijk, Kristel R. van; Koido, Masaru; Akiyama, Masato; Terao, Chikashi; Matsuda, Koichi; Walters, Robin G.; Lin, Kuang; Li, Liming; Millwood, Iona Y.; Chen, Zhengming; Rouleau, Guy A.; Zhou, Sirui; Rannikmae, Kristiina; Sudlow, Cathie L.M.; Houlden, Henry; Berg, Leonard H. van den; Dina, Christian; Naggara, Olivier; Gentric, Jean-Christophe; Shotar, Eimad; Eugène, François; Desal, Hubert; Winsvold, Bendik K S; Børte, Sigrid; Johnsen, Marianne Bakke; Brumpton, Ben Michael; Sandvei, Marie Søfteland; Willer, Cristen J.; Hveem, Kristian; Zwart, John-Anker; Verschuren, W.M. Monique; Friedrich, Christoph M.; Hirsch, Sven; Schilling, Sabine; Dauvillier, Jérôme; Martin, Olivier; Jones, Gregory T.; Bown, Matthew J.; Ko, Nerissa U.; Kim, Helen; Coleman, Jonathan R. I.; Breen, Gerome; Zaroff, Jonathan G. (Peer reviewed; Journal article, 2020)
      Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide ...
    • Genome-Wide Association Study to Identify Common Variants Associated with Brachial Circumference: A Meta-Analysis of 14 Cohorts 

      Boraska, V; Day-Williams, A; Franklin, CS; Elliott, KS; Panoutsopoulou, K; Tachmazidou, I; Albrecht, E; Bandinelli, S; Beilin, L; Bochud, M; Cadby, G; Ernst, F; Evans, David M.; Hayward, C; Hicks, AA; Huffman, Jennifer; Huth, C; James, AL; Klopp, N; Kolcic, I; Kutalik, Z; Lawlor, Debbie A.; Musk, AW; Pehlic, M; Pennell, CE; Perry, JRB; Peters, Annette; Polasek, O; St Pourcain, B; Ring, SM; Salvi, E; Schipf, S; Staessen, JA; Teumer, A; Timpson, N; Vitart, V; Warrington, NM; Yaghootkar, H; Zemunik, T; Zgaga, L; An, P; Anttila, V; Borecki, IB; Holmen, Jostein; Ntalla, I; Palotie, A; Pietilainen, KH; Wedenoja, J; Winsvold, Bendik Kristoffer Slagsvold; Dedoussis, GV; Kaprio, J; Province, MA; Zwart, John-Anker; Burnier, M; Campbell, H; Cusi, D; Smith, GD; Frayling, TM; Gieger, C; Palmer, LJ; Pramstaller, PP; Rudan, I; Volzke, H; Wichmann, HE; Wright, AF; Zeggini, E (Journal article; Peer reviewed, 2012)
      Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric ...
    • Headache and musculoskeletal complaints among subjects with self reported whiplash injury. The HUNT-2 study 

      Myran, Rigmor; Hagen, Knut; Svebak, Sven; Nygaard, Øystein Petter; Zwart, John-Anker (Journal article; Peer reviewed, 2011)
      Background: To evaluate the life-time prevalence of self reported whiplash injury and the relationship to chronic musculoskeletal complaints (MSCs) and headache in a large unselected adult population. Methods: Between ...
    • Headache as a predictor for dementia: The HUNT Study 

      Røttereng, Ane Karoline Stræte; Bosnes, Ole; Stordal, Eystein; Zwart, John-Anker; Linde, Mattias; Stovner, Lars Jacob; Hagen, Knut (Journal article; Peer reviewed, 2015)
      Background: The impact of headache on dementia is largely unknown. This study examined the association between headache and dementia using data from a large population-based study. Methods: This population-based study ...
    • High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019 

      Hagen, Knut; Stovner, Lars Jacob; Zwart, John-Anker (Peer reviewed; Journal article, 2020)
      Background Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investigate ...
    • Impact of technical variations on the ring-finger test for carpal tunnelsyndrome 

      Schulze, Daniel Gregor; Nordby, Karl-Christian; Småstuen, Milada Cvancarova; Clemm, Thomas; Grotle, Margreth; Zwart, John-Anker; Nilsen, Kristian Bernhard (Journal article; Peer reviewed, 2019)
      Objective To assess if recording the sensory latencies of the median and ulnar nerves one-by-one (consecutive) or at the same time (simultaneous) in the ring-finger test for carpal tunnel syndrome (CTS) will show equivalent ...
    • Incidence of total hip or knee replacement due to osteoarthritis in relation to thyroid function: a prospective cohort study (The Nord-Trøndelag Health Study) 

      Hellevik, Alf Inge; Johnsen, Marianne Bakke; Langhammer, Arnulf; Fenstad, Anne Marie; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Nordsletten, Lars (Journal article; Peer reviewed, 2017)
      Background To study whether thyroid function was associated with risk of hip or knee replacement due to primary osteoarthritis. Methods In a prospective cohort study, data from the second and third survey of the ...
    • Is chronic low back pain a risk factor for diabetes? The Nord-Trøndelag Health Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Sørgjerd, Elin Pettersen; Åsvold, Bjørn Olav; Zwart, John-Anker (Journal article; Peer reviewed, 2018)
      Objective The purpose of this study was to examine the risk of diabetes associated with the presence or absence of chronic low back pain, considering both cross-sectional and cohort data. Research design and methods ...
    • Is there a U-shaped relationship between physical activity in leisure time and risk of chronic low back pain? A follow-up in the HUNT Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article; Peer reviewed, 2016)
      Background Physical activity in leisure time is often considered to have favourable effects on the risk of low back pain (LBP), but demonstrating a definite association in epidemiological studies has proven difficult. The ...
    • Is there an Association between vitamin D status and risk of chronic low bak pain? A nested case-Control analysis in the Nord-Trøndelag Health Study 

      HEUCH, INGRID; Heuch, Ivar; Hagen, Knut; Mai, Xiao-Mei; Langhammer, Arnulf; Zwart, John-Anker (Journal article; Peer reviewed, 2017)
      Objectives: To explore potential associations between vitamin D status and risk of chronic low back pain (LBP) in a Norwegian cohort, and to investigate whether relationships depend on the season of blood sample collection. ...
    • Leisure time physical activity and the risk of hip or knee replacement due to primary osteoarthritis: A population based cohort study (The HUNT Study) 

      Johnsen, Marianne Bakke; Hellevik, Alf Inge; Baste, Valborg; Furnes, Ove; Langhammer, Arnulf; Flugsrud, Gunnar B; Nordsletten, Lars; Zwart, John-Anker; Storheim, Kjersti (Journal article; Peer reviewed, 2016)
      Background The relationship between leisure time physical activity (LPA) and hip and knee OA and subsequent joint replacement has not yet been clearly defined. Some studies have found the risk of knee replacement (TKR) to ...
    • Lifestyle factors and risk of migraine and tension-type headache. Follow-up data from the Nord-Trøndelag Health Surveys 1995-1997 and 2006-2008 

      Hagen, Knut; Åsberg, Anders Nikolai; Stovner, Lars Jacob; Linde, Mattias; Zwart, John-Anker; Winsvold, Bendik K S; HEUCH, INGRID (Journal article; Peer reviewed, 2018)
      Aims The aim of this population-based historical cohort study was to investigate the influence of lifestyle factors on the risk of developing migraine or tension-type headache (TTH). Methods Data from the Nord-Trøndelag ...
    • Metabolic syndrome as a risk factor for total hip or knee replacement due to primary osteoarthritis: A prospective cohort study (the HUNT study and the Norwegian arthroplasty register) 

      Hellevik, Alf Inge; Johnsen, Marianne Bakke; Langhammer, Arnulf; Baste, Valborg; Furnes, Ove; Storheim, Kjersti; Zwart, John-Anker; Flugsrud, Gunnar B; Nordsletten, Lars (Journal article; Peer reviewed, 2018)
      Objective: Biochemical changes associated with obesity may accelerate osteoarthritis beyond the effect of mechanical factors. This study investigated whether metabolic syndrome and its components (visceral obesity, ...
    • Migraine, obesity and body fat distribution - a population-based study 

      Kristoffersen, Espen Saxhaug; Børte, Sigrid; Hagen, Knut; Zwart, John-Anker; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)
      Background: Obesity has been linked to an increased prevalence of migraine, and to increased migraine attack frequency, but several questions are left unanswered by previous studies. We examined the relationship ...
    • Mitochondrial genome-wide association study of migraine – the HUNT Study 

      Børte, Sigrid; Zwart, John-Anker; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Thomas, Laurent; Fritsche, Lars G; Surakke, Ida; Nielsen, Jonas B.; Zhou, Wei; Wolford, Brooke; Vigeland, Magnus Dehli; Hagen, Knut; Kristoffersen, Espen Saxhaug; Nyholt, Dale R; Chasman, Daniel I; Brumpton, Ben Michael; Willer, Christen; Winsvold, Bendik K S (Peer reviewed; Journal article, 2020)
      Background Variation in mitochondrial DNA (mtDNA) has been indicated in migraine pathogenesis, but genetic studies to date have focused on candidate variants, with sparse findings. We aimed to perform the first mitochondrial ...
    • No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT Study 

      Hagen, Knut; Pettersen, Elin; Stovner, Lars Jacob; Skorpen, Frank; Zwart, John-Anker (Journal article; Peer reviewed, 2006-05-04)
      Background: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with ...
    • Parental migraine in relation to migraine in offspring: Family linkage analyses from the HUNT Study 

      Børte, Sigrid; Zwart, John-Anker; Stensland, Synne; Hagen, Knut; Winsvold, Bendik K S (Journal article; Peer reviewed, 2019)
      Background Migraine is known to run in families. While some clinical studies have indicated that migraine is disproportionally transmitted through the maternal line, this has not been examined in a population-based ...
    • Physical activity as a predictor for chronic musculoskeletal complaints: Results from the Nord-Trøndelag Heath Study 

      Holthe, H; Werpen, Hanne; Zwart, John-Anker; Hagen, Knut (Journal article; Peer reviewed, 2008-12-01)
      Background: Physical inactivity is associated with several diseases, but studies evaluating the association between chronic musculoskeletal complaints (MSCs) and physical exercise have shown conflicting results. The aim ...
    • Physical activity level at work and risk of chronic low back pain: A follow-up in the Nord-Trøndelag Health Study 

      Heuch, Ingrid; Heuch, Ivar; Hagen, Knut; Zwart, John-Anker (Journal article; Peer reviewed, 2017)
      Background: Physical activity in leisure time seems to reduce the risk of low back pain, but it is not known whether occupational activity, as recorded in a representative working population, produces a higher or lower ...