Browsing NTNU Open by Author "Slørdahl, Tobias Schmidt"
Now showing items 1-20 of 28
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Bystander memory T cells and IMiD/checkpoint therapy in multiple myeloma: A dangerous tango?
Sponaas, Anne-Marit; Waage, Anders; Vandsemb, Esten; Misund, Kristine; Børset, Magne; Sundan, Anders; Slørdahl, Tobias Schmidt; Standal, Therese (Peer reviewed; Journal article, 2021)In this review article we discuss the role of the memory T cells in multiple myeloma (MM) and how they may influence immune responses in patients that received immunomodulating drugs and check point therapy -
Comprehensive small RNA-sequencing of primary myeloma cells identifies miR-105-5p as a predictor of patient survival
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Bouma, Siri Anshushaug; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese; Mjelle, Robin (Journal article; Peer reviewed, 2022) -
Conversion of ATP to adenosine by CD39 and CD73 in multiple myeloma can be successfully targeted together with adenosine receptor A2A blockade
Yang, Rui; Elsaadi, Samah; Misund, Kristine; Abdollahi, Pegah; Vandsemb, Esten; Moen, Siv Helen; Kusnierczyk, Anna; Slupphaug, Geir; Standal, Therese; Waage, Anders; Slørdahl, Tobias Schmidt; Rø, Torstein Baade; Rustad, Even Holth; Sundan, Anders; Hay, Carl; Cooper, Zachary; Schuller, Alwin G.; Woessner, Richard; Borodowski, Alexandra; Menu, Eline; Børset, Magne; Sponaas, Anne-Marit (Peer reviewed; Journal article, 2020)Background PD1/PDL1-directed therapies have been unsuccessful for multiple myeloma (MM), an incurable cancer of plasma cells in the bone marrow (BM). Therefore, other immune checkpoints such as extracellular adenosine and ... -
Do testing, spacing, and interleaving improve exam scores among medical students? A randomized controlled trial.
Ulsaker, Håvard (Master thesis, 2023)Bakgrunn: Læringsstrategiene testing, intervaller og stokking har i flere studier vist seg å være effektive for læring og gjengivelse av kunnskap. Studiene som er utført har imidlertid ofte hatt enkle studiedesign, og de ... -
Examining the educational impact of the mini-CEX: a randomised controlled study
Smeby, Susanne Skjervold; Espeland, Torvald; Berg, Erik Andreas Rye; Samstad, Eivind; Lillebo, Børge; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2021)Background: The purpose of this study is to evaluate the mini-Clinical Evaluation Exercise (mini-CEX) as a formative assessment tool among undergraduate medical students, in terms of student perceptions, effects on direct ... -
Express Team-Based Learning (eTBL): A Time-Efficient TBL Approach in Neuroradiology
Smeby, Susanne Skjervold; Lillebo, Børge; Slørdahl, Tobias Schmidt; Berntsen, Erik Magnus (Peer reviewed; Journal article, 2019)Rationale and Objectives Team-based learning (TBL) is a student-centred, teacher-directed instructional method that promotes active learning. The application phase of TBL stimulates group discussion and critical thinking, ... -
Identification of the source of elevated hepatocyte growth factor levels in multiple myeloma patients
Rampa, Christoph Samuel; Tian, Erming; Våtsveen, Thea Kristin; Buene, Glenn; Slørdahl, Tobias Schmidt; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2014)Background Hepatocyte growth factor (HGF) is a pleiotropic cytokine which can lead to cancer cell proliferation, migration and metastasis. In multiple myeloma (MM) patients it is an abundant component of the bone marrow. ... -
Impact of inflammatory signals in multiple myeloma – the role of interleukin-32 and toll-like receptors
Tryggestad, Synne Stokke (Doctoral theses at NTNU;, Doctoral thesis, 2024)En studie av inflammatoriske signaler i myelomatose: fokus på rollen til interleukin-32 og toll-liknende reseptorer Myelomatose, også kalt beinmargkreft, skyldes ukontrollert vekst av plasmaceller i beinmargen. Plasmaceller ... -
Improving assessment quality in professional higher education: Could external peer review be the answer?
Smeby, Susanne Skjervold; Lillebo, Børge; Gynnild, Vidar; Samstad, Eivind; Standal, Rune; Knobel, Heidi; Vik, Anne; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2019)Summative assessment in professional higher education is important for student learning and making sound decisions about advancement and certification. Despite rigorous pre-test quality assurance procedures, problematic ... -
Incidence and prevention of skeletal related events in multiple myeloma patients: A population based real-world experience
Røra, Marie; Solberg, Margrete Skretting (Master thesis, 2023)Formål: Forbedrede behandlingsmuligheter av myelomatose kan påvirke forekomsten av skjelettrelaterte hendelser (SRE). Formålet med denne studien var å undersøke forekomsten av SRE og forebyggende bruk av osteoklasthemmere ... -
Incidence and prevention of skeletal related events in multiple myeloma patients: A population based real-world experience
Solberg, Margrete Skretting; Røra, Marie (Master thesis, 2023)Sammendrag Formål: Forbedrede behandlingsmuligheter av myelomatose kan påvirke forekomsten av skjelettrelaterte hendelser (SRE). Formålet med denne studien var å undersøke forekomsten av SRE og forebyggende bruk av ... -
Incidence and site of infections in patients with multiple myeloma – a retrospective population-based study
Vestad, Halvard Olavius (Master thesis, 2023)Bakgrunn: Myelomatose er den vanlegaste plasmacellemaligniteten og er assosiert med auka infeksjonsrisiko. Metode: Studien inkluderte pasientar diagnostisert med myelomatose på St. Olavs hospital mellom januar 2010 og ... -
Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells
Aass, Kristin Roseth; Mjelle, Robin; Kastnes, Martin Haugrud; Tryggestad, Synne Stokke; van den Brink, Luca M; Roseth, Ingrid Aass; Westhrin, Marita; Zahoor, Muhammad; Moen, Siv Helen; Nedal, Tonje Marie Vikene; Buene, Glenn; Misund, Kristine; Sponaas, Anne-Marit; Ma, Qianli; Sundan, Anders; Groen, Richard WJ; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese (Journal article; Peer reviewed, 2021)Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), ... -
Multiple Myeloma: Cancer Cell Intrinsic- and Tumor Microenvironmental Factors
Nedal, Tonje Marie Vikene (Doctoral theses at NTNU;2024:33, Doctoral thesis, 2024)Myelomatose (MM) er en hematologisk kreftsykdom som skyldes ukontrollert vekst av maligne plasmaceller i beinmargen. Myelomatose utvikler seg via to asymptomatiske forstadier: monoklonal gammopati av usikker betydning ... -
On the role of phosphatase of regenerating liver (PRL-) 3 in cell signaling and metabolism in multiple myeloma
Vandsemb, Esten N. (Doctoral theses at NTNU;2021:275, Doctoral thesis, 2021) -
Paired miRNA- and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma
Aass, Kristin Roseth; Nedal, Tonje Marie Vikene; Tryggestad, Synne Stokke; Haukås, Einar; Slørdahl, Tobias Schmidt; Waage, Anders; Standal, Therese; Mjelle, Robin (Peer reviewed; Journal article, 2022)Multiple myeloma (MM) is an incurable cancer of terminally differentiated plasma cells that proliferate in the bone marrow. miRNAs are promising biomarkers for risk stratification in MM and several miRNAs are shown to have ... -
Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration
Vandsemb, Esten Nymoen; Bertilsson, Helena; Abdollahi, Pegah; Størkersen, Øystein; Våtsveen, Thea Kristin; Rye, Morten Beck; Rø, Torstein Baade; Børset, Magne; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2016)Background: PRL-3 is a phosphatase implicated in oncogenesis in multiple cancers. In some cancers, notably carcinomas, PRL-3 is also associated with inferior prognosis and increased metastatic potential. In this study we ... -
Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration
Hjort, Magnus Aasved; Hov, Håkon; Abdollahi, Pegah; Vandsemb, Esten; Fagerli, Unn-Merete; Lund, Bendik; Slørdahl, Tobias Schmidt; Børset, Magne; Rø, Torstein Baade (Journal article; Peer reviewed, 2018)Background Phosphatase of regenerating liver-3 (PRL-3) is implicated in oncogenesis of hematological and solid cancers. PRL-3 expression increases metastatic potential, invasiveness and is associated with poor prognosis. ... -
Phosphatase of regenerating liver-3 as a target for treatment of B cell malignancies
Hjort, Magnus Aassved (Doctoral theses at NTNU;2018:241, Doctoral thesis, 2018)PRL-3 som et angrepsmål i behandlingen av B-cellekreft Akutt lymfatisk leukemi (ALL), Hodgkin lymfom (HL) og myelomatose er kreftsykdommer som oppstår fra B-lymfocytter. Disse cellene er en del av kroppens immunforsvar. ... -
Phosphatase of regenerating liver-3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance
Hjort, Magnus Aassved; Abdollahi, Pegah; Vandsemb, Esten Nymoen; Fenstad, Mona H.; Lund, Bendik; Slørdahl, Tobias Schmidt; Børset, Magne; Rø, Torstein Baade (Journal article; Peer reviewed, 2017)Phosphatase of regenerating liver-3 (PRL-3/PTP4A3) is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). With this study, we aim to characterize the biological ...