Browsing NTNU Open by Author "Hoff, Bård Helge"
Now showing items 1-20 of 92
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A comprehensive experimental study of five fundamental phenothiazine geometries increasing the diversity of the phenothiazine dye class for dye-sensitized solar cells
Buene, Audun Formo; Hagfeldt, Anders; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)Phenothiazine is a versatile scaffold frequently used in both pharmaceutical and photovoltaic applications. Still, the structural diversity within the class of phenothiazine sensitizers for dye-sensitized solar cells is ... -
Acetonitrile as a Building Block and Reactant
Hoff, Bård Helge (Journal article; Peer reviewed, 2018)Acetonitrile is popular as a solvent for performing organic reactions, as a ligand in inorganic chemistry, as a mobile phase in chromatography, and as an electrolyte solvent in dye-sensitized solar cells. This is mainly ... -
Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena
Kaspersen, Svein Jacob; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge (Journal article; Peer reviewed, 2012) -
Amination of N-protected pyrrolo[2,3-d]pyrimidines and complications with 5-iododerivatives
Rudolfsen, Madelen (Master thesis, 2023)Brystkreft er den vanligste kreftformen, og forekomsten av sykdommen er økende på verdensbasis. Proteinet human epidermal vekstfaktorreseptor 2 (HER2) blir overprodusert i flere av brystkrefttilfellene. Derfor er HER2 et ... -
Aminolysis of an Isophthalic Acid Derivative - Storage Stability and By-Product Formation
Hermanrud, Marie Mona (Master thesis, 2020)Abstract will be available on 2023-06-01 -
Asymmetric Synthesis of 2-Phenylpyrrolidines for SAR Study of Thienopyrimidine-based EGFR Kinase Inhibitors
Ramsnes, Andreas Behne (Master thesis, 2018)The aim of this master s thesis was to carry out a preliminary structure-activity relationship (SAR) study of thieno[2,3-d]pyrimidines with racemic and enantioenriched 2-phenylpyrrolidine as a substituent on C-4. One ... -
Auxiliary donors for phenothiazine sensitizers for dye-sensitized solar cells – how important are they really?
Buene, Audun Formo; Ose, Eline Ekornhol; Zakariassen, Ane Garborg; Hagfeldt, Anders; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)Auxiliary donors are common design motifs for phenothiazine sensitizers for dye-sensitized solar cells. Despite this, there are only a few reports on their overall contribution to the photon-to-electron conversion efficiency. ... -
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors
Han, Jin; Henriksen, Silje; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2016)The present study describes our continuous effort to develop epidermal growth factor receptor (EGFR) inhibitors based on the 6-aryl-pyrrolo[2,3-d]pyrimidin-4-amine scaffold. The activity-ADME space has been evaluated by ... -
Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)A chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
BMIDA-byggeblokker for fremstilling av nye organiske fargestoffer til "Dye-Sensitized Solar Cells" (DSSC)
Birkeland, Benedicte (Master thesis, 2016)Nye fenotiasin-baserte fargestoffer 10b og 13a-b er blitt syntetisert for bruk i Dye-Sensitized Solar Cells (DSSC). En sentral faktor i arbeidet har vært bruken av BMIDA-byggeblokk 7 som startpunkt for selektiv introduksjon ... -
Bromination and Suzuki reaction towards purine-based CSF-1R inhibitors
Hjøllo, Elisabeth (Master thesis, 2017)The aim of this master thesis was to develop a suitable synthetic procedure towards 6-amino-8-arylpurines as potential CSF-1R inhibitors. The chosen three-step route entailed thermal amination of 6-chloropurine with various ... -
Bruk av koblingskjemi i fremstilling av bioaktive tienopyrimidiner
Bugge, Steffen (Master thesis, 2011)Ved bruk av koblingskjemi har tre forskjellige synteseruter blitt utforsket. Disse tre rutene har blitt benyttet til å fremstille ti potensielt biologisk aktive tienopyrimidiner. Hovedvekten av arbeidet har ligget i å ... -
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit (Journal article; Peer reviewed, 2017)Cell extracts from A549, H460, and U2OS human cancer cell lines treated with cisplatin and docetaxel were analyzed by mass spectrometry (MS) proteomic analysis. The extracts were enriched for cellular signaling proteins ... -
Controlled patterning of metallic nanogaps and nanogap arrays via adhesion lithography
Luo, Sihai (Doctoral theses at NTNU;2021:181, Doctoral thesis, 2021)Existing nanofabrication methods typically rely on techniques such as optical lithography, electron-beam lithography or focused ion beam milling that enable high fidelity patterning but suffer from various limitations in ... -
Directed Lithiation of Protected 4-Chloropyrrolopyrimidine: Addition to Aldehydes and Ketones Aided by Bis(2-dimethylaminoethyl)ether
Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2023)Pyrrolopyrimidines are important scaffolds for the preparation of bioactive molecules. Therefore, developing efficient and flexible ways for selective functionalization of the pyrrolopyrimidine skeleton is of interest. We ... -
Economical Synthesis of 13C-Labeled Opiates, Cocaine Derivatives and Selected Urinary Metabolites by Derivatization of the Natural Products
Karlsen, Morten; Liu, Huiling; Johansen, Jon Eigill; Hoff, Bård Helge (Journal article; Peer reviewed, 2015)The illegal use of opiates and cocaine is a challenge world-wide, but some derivatives are also valuable pharmaceuticals. Reference samples of the active ingredients and their metabolites are needed both for controlling ... -
Effect of Auxiliary Donors on 3,8-Phenothiazine Dyes for Dye-Sensitized Solar Cells
Buene, Audun Formo; Christensen, Mats; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)Phenothiazines are one of the more common dye scaffolds for dye-sensitized solar cells. However, these sensitizers are exclusively based on a 3,7-substitution pattern. Herein, we have synthesized and characterized novel ... -
Effect of furan π-spacer and triethylene oxide methyl ether substituents on performance of phenothiazine sensitizers in dye-sensitized solar cells
Buene, Audun Formo; Boholm, Nanna; Hagfeldt, Anders; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)Conjugated π-spacers are used to improve the light harvesting properties of sensitizers for dye-sensitized solar cells. In several recent works, furan has outperformed other popular π-spacers such as thiophene and phenyl. ... -
Effect of Pyrene-Alkyne Donors and the Preparation of a Phenothiazine Literature Record Dye - Synthesis and Evaluation in DSSCs
Zakariassen, Ane Garborg (Master thesis, 2018)The desire to reduce CO2 emissions, combined with an increasing energy demand from the world's increasing population, calls for new environmentally clean energy resources. Solar energy stands out as one of the most viable ...