Browsing NTNU Open by Author "Hoff, Bård Helge"
Now showing items 1-20 of 100
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A comprehensive experimental study of five fundamental phenothiazine geometries increasing the diversity of the phenothiazine dye class for dye-sensitized solar cells
Buene, Audun Formo; Hagfeldt, Anders; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)Phenothiazine is a versatile scaffold frequently used in both pharmaceutical and photovoltaic applications. Still, the structural diversity within the class of phenothiazine sensitizers for dye-sensitized solar cells is ... -
Acetonitrile as a Building Block and Reactant
Hoff, Bård Helge (Journal article; Peer reviewed, 2018)Acetonitrile is popular as a solvent for performing organic reactions, as a ligand in inorganic chemistry, as a mobile phase in chromatography, and as an electrolyte solvent in dye-sensitized solar cells. This is mainly ... -
Activation of multiple stress responses in Staphylococcus aureus substantially lowers the minimal inhibitory concentration when combining two novel antibiotic drug candidates
Singleton, Amanda Holstad; Bergum, Olaug Elisabeth Torheim; Søgaard, Caroline Krogh; Røst, Lisa M.; Olsen, Cecilie Elisabeth; Blindheim, Fredrik Heen; Ræder, Synnøve Brandt; Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge; Bruheim, Per; Otterlei, Marit (Peer reviewed; Journal article, 2023)The past few decades have been plagued by an increasing number of infections caused by antibiotic resistant bacteria. To mitigate the rise in untreatable infections, we need new antibiotics with novel targets and drug ... -
Activity of 6-aryl-pyrrolo[2,3-d]pyrimidine-4-amines to Tetrahymena
Kaspersen, Svein Jacob; Sundby, Eirik; Charnock, Colin; Hoff, Bård Helge (Journal article; Peer reviewed, 2012) -
Adamantyl Side Chains as Anti-Aggregating Moieties in Dyes for Dye-Sensitized Solar Cells
Almenningen, David Moe; Haga, Brita Susanne; Hansen, Henrik Erring; Buene, Audun Formo; Hoff, Bård Helge; Gautun, Odd Reidar (Peer reviewed; Journal article, 2022)Designing and evaluating novel dye concepts is crucial for the development of the field of dye-sensitized solar cells (DSSCs). In our recent report, the novel concept of tethering the anti-aggregation additive chenodeoxycholic ... -
Amination of N-protected pyrrolo[2,3-d]pyrimidines and complications with 5-iododerivatives
Rudolfsen, Madelen (Master thesis, 2023)Brystkreft er den vanligste kreftformen, og forekomsten av sykdommen er økende på verdensbasis. Proteinet human epidermal vekstfaktorreseptor 2 (HER2) blir overprodusert i flere av brystkrefttilfellene. Derfor er HER2 et ... -
Aminolysis of an Isophthalic Acid Derivative - Storage Stability and By-Product Formation
Hermanrud, Marie Mona (Master thesis, 2020)Abstract will be available on 2023-06-01 -
Anilines in acid catalyzed amination with 4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Svergja, Hanne (Master thesis, 2023)Pyrrolopyrimidiner har en omfattende farmakologisk profil og er av stor betydning i mange biologisk aktive forbindelser. Syre-katalysert aminering av slike heterosykliske forbindelser er en velkjent strategi innen syntese ... -
Asymmetric Synthesis of 2-Phenylpyrrolidines for SAR Study of Thienopyrimidine-based EGFR Kinase Inhibitors
Ramsnes, Andreas Behne (Master thesis, 2018)The aim of this master s thesis was to carry out a preliminary structure-activity relationship (SAR) study of thieno[2,3-d]pyrimidines with racemic and enantioenriched 2-phenylpyrrolidine as a substituent on C-4. One ... -
Auxiliary donors for phenothiazine sensitizers for dye-sensitized solar cells – how important are they really?
Buene, Audun Formo; Ose, Eline Ekornhol; Zakariassen, Ane Garborg; Hagfeldt, Anders; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)Auxiliary donors are common design motifs for phenothiazine sensitizers for dye-sensitized solar cells. Despite this, there are only a few reports on their overall contribution to the photon-to-electron conversion efficiency. ... -
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors
Han, Jin; Henriksen, Silje; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2016)The present study describes our continuous effort to develop epidermal growth factor receptor (EGFR) inhibitors based on the 6-aryl-pyrrolo[2,3-d]pyrimidin-4-amine scaffold. The activity-ADME space has been evaluated by ... -
Benzoylated uronic acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)A chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
Benzoylated uronic Acid building blocks and synthesis of N-uronate conjugates of lamotrigine
Esmurziev, Aslan; Reimers, Arne; Andreassen, Trygve; Simic, Nebojsa; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2012)chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building ... -
BMIDA-byggeblokker for fremstilling av nye organiske fargestoffer til "Dye-Sensitized Solar Cells" (DSSC)
Birkeland, Benedicte (Master thesis, 2016)Nye fenotiasin-baserte fargestoffer 10b og 13a-b er blitt syntetisert for bruk i Dye-Sensitized Solar Cells (DSSC). En sentral faktor i arbeidet har vært bruken av BMIDA-byggeblokk 7 som startpunkt for selektiv introduksjon ... -
Bromination and Suzuki reaction towards purine-based CSF-1R inhibitors
Hjøllo, Elisabeth (Master thesis, 2017)The aim of this master thesis was to develop a suitable synthetic procedure towards 6-amino-8-arylpurines as potential CSF-1R inhibitors. The chosen three-step route entailed thermal amination of 6-chloropurine with various ... -
Bruk av koblingskjemi i fremstilling av bioaktive tienopyrimidiner
Bugge, Steffen (Master thesis, 2011)Ved bruk av koblingskjemi har tre forskjellige synteseruter blitt utforsket. Disse tre rutene har blitt benyttet til å fremstille ti potensielt biologisk aktive tienopyrimidiner. Hovedvekten av arbeidet har ligget i å ... -
Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel
Petrovic, Voin; Olaisen, Camilla; Sharma, Animesh; Nepal, Anala; Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Slupphaug, Geir; Otterlei, Marit (Journal article; Peer reviewed, 2017)Cell extracts from A549, H460, and U2OS human cancer cell lines treated with cisplatin and docetaxel were analyzed by mass spectrometry (MS) proteomic analysis. The extracts were enriched for cellular signaling proteins ... -
Controlled patterning of metallic nanogaps and nanogap arrays via adhesion lithography
Luo, Sihai (Doctoral theses at NTNU;2021:181, Doctoral thesis, 2021)Existing nanofabrication methods typically rely on techniques such as optical lithography, electron-beam lithography or focused ion beam milling that enable high fidelity patterning but suffer from various limitations in ... -
Directed Lithiation of Protected 4-Chloropyrrolopyrimidine: Addition to Aldehydes and Ketones Aided by Bis(2-dimethylaminoethyl)ether
Bjørnstad, Frithjof Andreas; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2023)Pyrrolopyrimidines are important scaffolds for the preparation of bioactive molecules. Therefore, developing efficient and flexible ways for selective functionalization of the pyrrolopyrimidine skeleton is of interest. We ... -
Economical Synthesis of 13C-Labeled Opiates, Cocaine Derivatives and Selected Urinary Metabolites by Derivatization of the Natural Products
Karlsen, Morten; Liu, Huiling; Johansen, Jon Eigill; Hoff, Bård Helge (Journal article; Peer reviewed, 2015)The illegal use of opiates and cocaine is a challenge world-wide, but some derivatives are also valuable pharmaceuticals. Reference samples of the active ingredients and their metabolites are needed both for controlling ...