Browsing NTNU Open by Author "Iversen, Ann-Charlotte"
Now showing items 21-40 of 49
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Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Vollset, Stein Emil; Iversen, Ann-Charlotte; Austgulen, Rigmor; Daltveit, Anne Kjersti (Journal article; Peer reviewed, 2017)Background Preeclampsia is a severe pregnancy disorder often complicated by reduced fetal growth or preterm delivery and is associated with long‐term maternal morbidity and mortality. We aimed to assess the association ... -
Inflammation by pattern recognition receptors in the uterine wall decidua and the placenta of normal and preeclamptic pregnancies
Silva, Gabriela Brettas (Doctoral theses at NTNU;2020:207, Doctoral thesis, 2020)Preeclampsia is a serious inflammatory disorder characterized by hypertension and proteinuria in the second half of pregnancy. It is often associated with severe maternal and fetal complications, such as fetal growth ... -
Inflammation in Pregnancy – A Study of Pattern Recognition Receptors in Trophoblasts
Tangerås, Line Haugstad (Master thesis, 2011)Normal pregnancy is characterized by a mildly elevated state of inflammation, as a consequence of the woman’s body adapting to the presence of the growing fetus. The placenta is established in early pregnancy, and constitutes ... -
InterPregGen: Genetic studies of pre-eclampsia in three continents
Morgan, Linda; McGinnis, Ralph; Steinthorsdottir, Valgerdur; Syvatova, Gulnara; Zakhidova, Nodira; Lee, Wai Kwong; Iversen, Ann-Charlotte; Magnus, Per; Walker, James; Casas, Juan Pablo; Sultanov, Saidazim; Laivuori, Hannele (Journal article; Peer reviewed, 2014)Pre-eclampsia is a major cause of maternal and fetal mortality in pregnancy. The identification of genetic variants which predispose to pre-eclampsia demands large DNA collections from affected mothers and babies and ... -
Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia
Pabalan, Noel; Jarjanazi, H; Sun, Chen; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)The non-classical major histocompatibility complex, human leukocyte antigen (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction between maternal immune cells and fetal trophoblasts invading the ... -
Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics
Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ... -
Metabolomic biomarkers in serum and urine in women with preeclampsia
Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article, 2014)Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study
Austdal, Marie (Master thesis, 2012)Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ... -
Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity
Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ... -
Metformin exposure in utero and immunological effects in the offspring at 8 years of age: The PedMet Study
Skage, Johanne Eikeland (Master thesis, 2022)Sammendrag Bakgrunn Polycystisk ovariesyndrom (PCOS) er den vanligste endokrinologiske sykdommen blant kvinner i reproduktiv alder, og rammer opptil 17%. Syndromet kjennetegnes av irregulære menstruasjoner, hyperandrogenisme ... -
New immune phenotypes for treatment response in high-grade serous ovarian carcinoma patients
Torkildsen, Cecilie Fredvik; Austdal, Marie; Jarmund, Anders Hagen; Kleinmanns, Katrin; Lamark, Eva Karin; Nilsen, Elisabeth Berge; Stefansson, Ingunn Marie; Sande, Ragnar; Iversen, Ann-Charlotte; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line (Journal article; Peer reviewed, 2024)Despite advances in surgical and therapeutic approaches, high-grade serous ovarian carcinoma (HGSOC) prognosis remains poor. Surgery is an indispensable component of therapeutic protocols, as removal of all visible tumor ... -
Pathological processes in the uterine wall decidua in preeclampsia and fetal growth restriction
Mundal, Siv Boon (Doctoral theses at NTNU;2020:11, Doctoral thesis, 2020)Sykdomsprosesser i decidua ved svangerskapsforgiftning og føtal veksthemming Morkaken består av en maternell del som utvikles fra livmorveggen (decidua) og en føtal del som er bygget opp av fosterceller (placenta). ... -
Pattern recognition receptor mediated inflammation in placental trophoblasts
Stødle, Guro Sannerud (Doctoral theses at NTNU;2017:324, Doctoral thesis, 2017)Studie av mekanismer for betennelse i morkaken Betennelse (inflammasjon) er en immunrespons som kroppen setter i gang for å beskytte seg mot infeksjoner og vevsskade. Alle mennesker er født med "mønster-gjenkjennende" ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to ... -
Placental inflammation by HMGB1 activation of TLR4 at the syncytium
Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal ... -
Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts
Stødle, Guro; Silva, Gabriela; Tangerås, Line Haugstad; Gierman, Lobke; Nervik, Ingunn; Dahlberg, Unn; Sun, Chen; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2018)Pre‐eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger‐sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR ... -
Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22
Løset, Mari; Johnson, Matthew P.; Melton, Philip E.; Ang, Wei; Huang, Rae-Chi; Mori, Trevor; Beilin, Lawrence J.; Pennell, Craig E.; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, Christine E.; Blangero, John; Brennecke, Shaun P.; Moses, Eric K (Journal article; Peer reviewed, 2014)Objective Four putative single nucleotide polymorphism (SNP) risk variants at the preeclampsia susceptibility locus on chromosome 2q22; rs2322659 (LCT), rs35821928 (LRP1B), rs115015150 (RND3) and rs17783344 (GCA), were ... -
Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins
Torkildsen, Cecilie Fredvik; Austdal, Marie; Iversen, Ann-Charlotte; Bathen, Tone Frost; Giskeødegård, Guro F.; Nilsen, Elisabeth Berge; Iversen, Grete Alræk; Sande, Ragnar; Bjørge, Line; Thomsen, Liv Cecilie Vestrheim (Peer reviewed; Journal article, 2023)High-grade serous ovarian carcinoma (HGSOC) is the most common and deadliest ovarian cancer subtype. Despite advances in treatment, the overall prognosis remains poor. Regardless of efforts to develop biomarkers to predict ...