Browsing NTNU Open by Author "Iversen, Ann-Charlotte"

Now showing items 21-40 of 45

    • InterPregGen: Genetic studies of pre-eclampsia in three continents 

      Morgan, Linda; McGinnis, Ralph; Steinthorsdottir, Valgerdur; Syvatova, Gulnara; Zakhidova, Nodira; Lee, Wai Kwong; Iversen, Ann-Charlotte; Magnus, Per; Walker, James; Casas, Juan Pablo; Sultanov, Saidazim; Laivuori, Hannele (Journal article; Peer reviewed, 2014)
      Pre-eclampsia is a major cause of maternal and fetal mortality in pregnancy. The identification of genetic variants which predispose to pre-eclampsia demands large DNA collections from affected mothers and babies and ...

    • Meta-analysis of the human leukocyte antigen-G (HLA-G) 14bp insertion/deletion polymorphism as a risk factor for preeclampsia 

      Pabalan, Noel; Jarjanazi, H; Sun, Chen; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      The non-classical major histocompatibility complex, human leukocyte antigen (HLA)-G, plays an important role in pregnancy. HLA-G mediates proper interaction between maternal immune cells and fetal trophoblasts invading the ...

    • Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics 

      Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ...

    • Metabolomic biomarkers in serum and urine in women with preeclampsia 

      Austdal, Marie; Skråstad, Ragnhild; Gundersen, Astrid; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article, 2014)
      Objective To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis. Methods Urine and serum ...

    • Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study 

      Austdal, Marie (Master thesis, 2012)
      Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ...

    • Metabolomic Biomarkers of Preeclampsia: An NMR Protocol Development and Pilot Study 

      Austdal, Marie (Master thesis, 2012)
      Preeclampsia is a serious complication of pregnancy, which presents risk to both the expectant mother and to the fetus. It affects 3-8% of pregnancies, resolves only upon delivery, and is a major cause of preterm birth. ...

    • Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity 

      Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...

    • Metformin exposure in utero and immunological effects in the offspring at 8 years of age: The PedMet Study 

      Skage, Johanne Eikeland (Master thesis, 2022)
      Sammendrag Bakgrunn Polycystisk ovariesyndrom (PCOS) er den vanligste endokrinologiske sykdommen blant kvinner i reproduktiv alder, og rammer opptil 17%. Syndromet kjennetegnes av irregulære menstruasjoner, hyperandrogenisme ...

    • Pathological processes in the uterine wall decidua in preeclampsia and fetal growth restriction 

      Mundal, Siv Boon (Doctoral theses at NTNU;2020:11, Doctoral thesis, 2020)
      Sykdomsprosesser i decidua ved svangerskapsforgiftning og føtal veksthemming Morkaken består av en maternell del som utvikles fra livmorveggen (decidua) og en føtal del som er bygget opp av fosterceller (placenta). ...

    • Pattern recognition receptor mediated inflammation in placental trophoblasts 

      Stødle, Guro Sannerud (Doctoral theses at NTNU;2017:324, Doctoral thesis, 2017)
      Studie av mekanismer for betennelse i morkaken Betennelse (inflammasjon) er en immunrespons som kroppen setter i gang for å beskytte seg mot infeksjoner og vevsskade. Alle mennesker er født med "mønster-gjenkjennende" ...

    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals ...

    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to ...

    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal ...

    • Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts 

      Stødle, Guro; Silva, Gabriela; Tangerås, Line Haugstad; Gierman, Lobke; Nervik, Ingunn; Dahlberg, Unn; Sun, Chen; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2018)
      Pre‐eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger‐sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR ...

    • Preeclampsia and cardiovascular disease share genetic risk factors on chromosome 2q22 

      Løset, Mari; Johnson, Matthew P.; Melton, Philip E.; Ang, Wei; Huang, Rae-Chi; Mori, Trevor; Beilin, Lawrence J.; Pennell, Craig E.; Roten, Linda Tømmerdal; Iversen, Ann-Charlotte; Austgulen, Rigmor; East, Christine E.; Blangero, John; Brennecke, Shaun P.; Moses, Eric K (Journal article; Peer reviewed, 2014)
      Objective Four putative single nucleotide polymorphism (SNP) risk variants at the preeclampsia susceptibility locus on chromosome 2q22; rs2322659 (LCT), rs35821928 (LRP1B), rs115015150 (RND3) and rs17783344 (GCA), were ...

    • Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins 

      Torkildsen, Cecilie Fredvik; Austdal, Marie; Iversen, Ann-Charlotte; Bathen, Tone Frost; Giskeødegård, Guro F.; Nilsen, Elisabeth Berge; Iversen, Grete Alræk; Sande, Ragnar; Bjørge, Line; Thomsen, Liv Cecilie Vestrheim (Peer reviewed; Journal article, 2023)
      High-grade serous ovarian carcinoma (HGSOC) is the most common and deadliest ovarian cancer subtype. Despite advances in treatment, the overall prognosis remains poor. Regardless of efforts to develop biomarkers to predict ...

    • Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial 

      Moholdt, Trine; Ashby, Emily Rose; Tømmerdal, Karina Hammer; Lemoine, Maeliss Cynthia Chloe; Holm, Rebecca Lyng; Sætrom, Pål; Iversen, Ann-Charlotte; Ravi, Anuradha; Simpson, Melanie Rae; Giskeødegård, Guro F. (Peer reviewed; Journal article, 2023)
      Download PDFPDF Protocol Randomised controlled trial of exercise training during lactation on breast milk composition in breastfeeding people with overweight/obesity: a study protocol for the MILKSHAKE trial ...

    • Randomised controlled trial of preconception lifestyle intervention on maternal and offspring health in people with increased risk of gestational diabetes: study protocol for the BEFORE THE BEGINNING trial 

      Sujan, Md Abu Jafar; Skarstad, Hanna Margrethe Storheil; Rosvold, Guro; Fougner, Stine Lyngvi; Nyrnes, Siri Ann; Iversen, Ann-Charlotte; Follestad, Turid; Salvesen, Kjell Åsmund Blix; Moholdt, Trine (Peer reviewed; Journal article, 2023)
      Introduction: Gestational diabetes mellitus (GDM) is associated with increased risk for type 2 diabetes in the mother and cardiometabolic diseases in the child. The preconception period is an optimal window to adapt the ...

    • Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort 

      Thomsen, Liv Cecilie Vestrheim; Melton, Philip E.; Tollaksen, Kjersti; Lyslo, Ingvill; Roten, Linda Tømmerdal; Odland, Maria Lisa; Strand, Kristin Melheim; Nygård, Ottar; Sun, Chen; Iversen, Ann-Charlotte; Austgulen, Rigmor; Moses, Eric; Bjørge, Line (Peer reviewed; Journal article, 2015)
      Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for ...

    • Serum cytokine patterns in first half of pregnancy 

      Stokkeland, Live Marie Tobiesen; Giskeødegård, Guro F.; Stridsklev, Solhild; Ryan, Liv; Steinkjer, Bjørg; Tangerås, Line Haugstad; Vanky, Eszter; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Introduction Human pregnancy is a state of elevated maternal systemic inflammation, and pregnancy complications are often associated with a dysfunctional immune response. The network of cytokines reflects this complex ...