Now showing items 21-30 of 30

    • Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis 

      Darvekar, Sagar; Juzenas, Petras; Oksvold, Morten Pedersen; Kleinauskas, Andrius; Holien, Toril; Christensen, Eidi; Stokke, Trond; Sioud, Mouldy; Qian, Peng (Peer reviewed; Journal article, 2020)
      Extracorporeal photopheresis (ECP), a modality that exposes isolated leukocytes to the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) light, is used to treat conditions such as cutaneous T-cell lymphoma ...
    • Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3 

      Abdollahi, Pegah; Vandsemb, Esten Nymoen; Hjort, Magnus Aassved; Misund, Kristine; Holien, Toril; Sponaas, Anne-Marit; Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Børset, Magne (Journal article; Peer reviewed, 2016)
      Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of ...
    • Targeting FKBP12 potentiates bone morphogenetic protein signaling in multiple myeloma cells 

      Kastnes, Martin Haugrud (Master thesis, 2019)
      Abstract Background Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. Although new treatments approved in the last decades have improved patient outcomes considerably, most patients relapse ...
    • Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells 

      Müller, Rebekka; Misund, Kristine; Holien, Toril; Bachke, Siri; Gilljam, Karin Margaretha; Våtsveen, Thea Kristin; Rø, Torstein Baade; Bellacchio, E.; Sundan, Anders; Otterlei, Marit (Journal article; Peer reviewed, 2013)
      Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous ...
    • TGF-β contamination of purified recombinant GDF15 

      Olsen, Oddrun Elise; Skjærvik, Anette; Størdal, Berit Fladvad; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2017)
      Purified recombinant proteins for use in biomedical research are invaluable to investigate protein function. However, purity varies in protein batches made in mammalian expression systems, such as CHO-cells or HEK293-cells. ...
    • The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma 

      Sponaas, Anne-Marit; Moen, Siv Helen; Liabakk, Nina-Beate; Feyzi, Emadoldin; Holien, Toril; Kvam, Solveig; Grøseth, Lill Anny Gunnes; Størdal, Berit Fladvad; Buene, Glenn; Espevik, Terje; Waage, Anders; Standal, Therese; Sundan, Anders (Journal article; Peer reviewed, 2015)
      Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth ...
    • The role of BMP receptor ALK2 in myeloma cells 

      Olsen, Oddrun Elise (Doctoral theses at NTNU;2017:65, Doctoral thesis, 2017)
      ROLLEN TIL BMP-RESEPTOR ALK2 I MYELOMCELLER Myelomgruppa ved Institutt for Kreftforskning og Molekylærmedisin ved NTNU i Trondheim har i mange år arbeidet med myelomatose. Myelomatose, også kjent som beinmargskreft, er ...
    • The role of bone morphogenetic protein-9 in multiple myeloma 

      Olsen, Oddrun Elise (Master thesis, 2012)
      Multiple myeloma (MM) is a malignancy of antibody producing plasma cells located in the bone marrow. MM is also called bone marrow cancer and is the second most common hematologic cancer. The exact cause for this type of ...
    • The role of bone morphogenetic proteins in myeloma cell survival 

      Holien, Toril; Sundan, Anders (Journal article; Peer reviewed, 2014)
      Multiple myeloma is characterized by slowly growing clones of malignant plasma cells in the bone marrow. The malignant state is frequently accompanied by osteolytic bone disease due to a disturbed balance between osteoblasts ...
    • Uttrykk og betydning av GRP78 i myelomceller 

      Husteli Kristiansen, Kine (Master thesis, 2014)
      Myelomatose, også kjent som beinmargskreft, er en hematologisk malign sykdom i antistoffproduserende plasmaceller i beinmargen. Kreftsykdommen er fortsatt uhelbredelig, og resistensutvikling mot medikamenter er en stor ...