Now showing items 21-40 of 42

    • Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells 

      Starheim, Kristian Kobbenes; Holien, Toril; Misund, Kristine; Johansson, Ida; Baranowska, Katarzyna Anna; Sponaas, Anne Marit; Hella, Hanne; Buene, Glenn; Waage, Anders; Sundan, Anders; Bjørkøy, Geir (Journal article; Peer reviewed, 2016)
      Multiple myeloma (myeloma in short) is an incurable cancer of antibody-producing plasma cells that comprise 13% of all hematological malignancies. The proteasome inhibitor bortezomib has improved treatment significantly, ...
    • Mcl-1 and Bcl-xL levels predict responsiveness to dual MEK/Bcl-2 inhibition in B-cell malignancies 

      Melvold, Katrine; Giliberto, Mariaserena; Karlsen, Linda; Ayuda-Duran, Maria del Pilar; Hanes, Robert; Holien, Toril; Enserink, Jorrit; Brown, Jennifer R.; Tjønnfjord, Geir Erland; Tasken, Kjetil; Skånland, Sigrid Strand (Peer reviewed; Journal article, 2021)
      Most patients with chronic lymphocytic leukemia (CLL) initially respond to targeted therapies, but eventually relapse and develop resistance. Novel treatment strategies are therefore needed to improve patient outcomes. ...
    • Monitoring multiple myeloma by quantification of recurrent mutations in serum 

      Rustad, Even Holth; Coward, Eivind; Skytøen, Emilie R; Misund, Kristine; Holien, Toril; Standal, Therese; Børset, Magne; Beisvag, Vidar; Myklebost, Ola; Meza, Leonardo Zepeda; Hong, Yan Dai; Sundan, Anders; Waage, Anders (Journal article; Peer reviewed, 2017)
      Circulating tumor DNA is a promising biomarker to monitor tumor load and genome alterations. We explored the presence of circulating tumor DNA in multiple myeloma patients and its relation to disease activity during long-term ...
    • Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines 

      Giliberto, Mariaserena; Miranda Santana, Leonardo; Holien, Toril; Misund, Kristine; Nakken, Sigve; Vodak, Daniel; Hovig, Eivind; Meza, Leonardo Zepeda; Coward, Eivind; Waage, Anders; Tasken, Kjetil; Skånland, Sigrid S (Peer reviewed; Journal article, 2022)
      Introduction: Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug responses vary greatly, and there is an unmet ...
    • MYC amplifications in myeloma cell lines; correlation with MYC-inhibitor efficacy 

      Holien, Toril; Misund, Kristine; Olsen, Oddrun Elise; Baranowska, Katarzyna Anna; Buene, Glenn; Børset, Magne; Waage, Anders; Sundan, Anders (Journal article; Peer reviewed, 2015)
      In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary ...
    • Novel pathways to metastasis of breast cancer 

      Wolowczyk, Camilla Izabel (Doctoral theses at NTNU;2020:397, Doctoral thesis, 2020)
      Ny diagnostikk for persontilpasset behandling av brystkreft Rundt 3600 kvinner blir årlig diagnostisert med brystkreft i Norge. Bedre diagnostikk og behandling bidrar til at flere enn 90% av brystkreftpasientene i dag ...
    • Optimalisering av RNA-analyser; utprøving av Epstein-Barr virus-transformerte lymfoblastoide cellelinjer som kontrollmateriale 

      Brændvik, Sofie Emilie; Grønli, Elisabeth (Bachelor thesis, 2022)
      Avdeling for medisinsk genetikk (AMG) på St. Olavs Hospital har behov for nytt kontrollmateriale til analyser av RNA. Gentesting kan utføres på RNA-nivå som et supplement til gentesting på DNA-nivå. Dette utføres som regel ...
    • Perturbation of the c-Myc-Max Protein-Protein Interaction via Synthetic α-Helix Mimetics 

      Jung, Kwan-Young; Wang, Huabo; Teriete, Peter; Yap, Jeremy L; Chen, Lijia; Lanning, Maryanna E; Hu, Angela; Lambert, Lester J; Holien, Toril; Sundan, Anders; Cosford, Nicholas D P; Prochownik, Edward V; Fletcher, Steven (Journal article; Peer reviewed, 2015)
      The rational design of inhibitors of the bHLH-ZIP oncoprotein c-Myc is hampered by a lack of structure in its monomeric state. We describe herein the design of novel, low-molecular-weight, synthetic α-helix mimetics that ...
    • Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides 

      Kolos, Jürgen M; Pomplun, Sebastian; Jung, Sascha; Rieß, Benedikt; Purder, Patrick L; Voll, Andreas M; Merz, Stephanie; Gnatzy, Monika; Geiger, Thomas M; Quist-Løkken, Ingrid; Jatzlau, Jerome; Knaus, Petra; Holien, Toril; Bracher, Andreas; Meyners, Christian; Czodrowski, Paul; Krewald, Vera; Hausch, Felix (Journal article; Peer reviewed, 2021)
      Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic ...
    • Potentiation of BMP and activin induced apoptosis in multiple myeloma cells by FK506 

      Booc, Nerissa Rae (Master thesis, 2019)
      Myelomatose er en hematologisk kreft som kjennetegnes av maligne plasmaceller som akkumuleres in benmargen. Akkumulering av myelomceller kan forårsake osteolyse mens monoklonale immunoglobuliner produsert av myelomceller ...
    • Receptor binding competition: A paradigm for regulating TGF-β family action 

      Martinez-Hackert, Erik; Sundan, Anders; Holien, Toril (Peer reviewed; Journal article, 2020)
      The transforming growth factor (TGF)-β family is a group of structurally related, multifunctional growth factors, or ligands that are crucially involved in the development, regulation, and maintenance of animal tissues. ...
    • Sammenligning av to ulike kassetter for oppsett av blodtypeantistoffscreening på analysemaskinen Ortho Vision Max 

      Persgård, Sarah (Bachelor thesis, 2023)
      Man kan danne blodtypeantistoff mot fremmede blodtypeantigener, dersom man gjennom graviditet eller blodtransfusjon blir utsatt for fremmede blodtypeantigener. Disse blodtypeantistoffene kan føre til hemolytisk ...
    • Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis 

      Darvekar, Sagar; Juzenas, Petras; Oksvold, Morten Pedersen; Kleinauskas, Andrius; Holien, Toril; Christensen, Eidi; Stokke, Trond; Sioud, Mouldy; Qian, Peng (Peer reviewed; Journal article, 2020)
      Extracorporeal photopheresis (ECP), a modality that exposes isolated leukocytes to the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) light, is used to treat conditions such as cutaneous T-cell lymphoma ...
    • Src family kinases are regulated in multiple myeloma cells by phosphatase of regenerating liver-3 

      Abdollahi, Pegah; Vandsemb, Esten Nymoen; Hjort, Magnus Aassved; Misund, Kristine; Holien, Toril; Sponaas, Anne-Marit; Rø, Torstein Baade; Slørdahl, Tobias Schmidt; Børset, Magne (Journal article; Peer reviewed, 2016)
      Phosphatase of regenerating liver-3 (PTP4A3/PRL-3) is a dual-specificity phosphatase that is upregulated in various types of cancers and is related to poor prognosis and aggressive tumor behavior. The expression level of ...
    • Targeting FKBP12 potentiates bone morphogenetic protein signaling in multiple myeloma cells 

      Kastnes, Martin Haugrud (Master thesis, 2019)
      Abstract Background Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells. Although new treatments approved in the last decades have improved patient outcomes considerably, most patients relapse ...
    • Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells 

      Müller, Rebekka; Misund, Kristine; Holien, Toril; Bachke, Siri; Gilljam, Karin Margaretha; Våtsveen, Thea Kristin; Rø, Torstein Baade; Bellacchio, E.; Sundan, Anders; Otterlei, Marit (Journal article; Peer reviewed, 2013)
      Multiple myeloma is a hematological cancer that is considered incurable despite advances in treatment strategy during the last decade. Therapies targeting single pathways are unlikely to succeed due to the heterogeneous ...
    • TGF-β contamination of purified recombinant GDF15 

      Olsen, Oddrun Elise; Skjærvik, Anette; Størdal, Berit Fladvad; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2017)
      Purified recombinant proteins for use in biomedical research are invaluable to investigate protein function. However, purity varies in protein batches made in mammalian expression systems, such as CHO-cells or HEK293-cells. ...
    • The proportion of CD16+CD14dim monocytes increases with tumor cell load in bone marrow of patients with multiple myeloma 

      Sponaas, Anne-Marit; Moen, Siv Helen; Liabakk, Nina-Beate; Feyzi, Emadoldin; Holien, Toril; Kvam, Solveig; Grøseth, Lill Anny Gunnes; Størdal, Berit Fladvad; Buene, Glenn; Espevik, Terje; Waage, Anders; Standal, Therese; Sundan, Anders (Journal article; Peer reviewed, 2015)
      Multiple myeloma is an incurable cancer with expansion of malignant plasma cells in the bone marrow. Previous studies have shown that monocytes and macrophages in the bone marrow milieu are important for tumor growth ...
    • The role of BMP receptor ALK2 in myeloma cells 

      Olsen, Oddrun Elise (Doctoral theses at NTNU;2017:65, Doctoral thesis, 2017)
      ROLLEN TIL BMP-RESEPTOR ALK2 I MYELOMCELLER Myelomgruppa ved Institutt for Kreftforskning og Molekylærmedisin ved NTNU i Trondheim har i mange år arbeidet med myelomatose. Myelomatose, også kjent som beinmargskreft, er ...
    • The role of bone morphogenetic protein-9 in multiple myeloma 

      Olsen, Oddrun Elise (Master thesis, 2012)
      Multiple myeloma (MM) is a malignancy of antibody producing plasma cells located in the bone marrow. MM is also called bone marrow cancer and is the second most common hematologic cancer. The exact cause for this type of ...