Blar i NTNU Open på forfatter "Bruheim, Per"
-
Mass Spectrometrical Analysis in Lipidomics
Mainali, Anushree (Master thesis, 2020)Lipider representerer over femti tusen arter av biomolekyler med et like stort utvalg av biologiske funksjoner. De fungerer som den viktigste strukturelle komponenten i forskjellige biologiske membraner, som store aktører ... -
Mass Spectrometry Based Metabolite Profiling of Cytostatic Induced Stress Response in the Prostate Cancer Cell Line DU 145
Græe, Marit Aas (Master thesis, 2014)The discovery of AlkB homologue 2 PCNA-interacting motif (APIM), a new motif interacting with proliferating cell nuclear antigen (PCNA), has opened up a new possible therapeutic window concerning cancer treatments. This ... -
Mass spectrometry- based metabolite analyses in Streptomyces coelicolor
Klubicka, Lidija (Master thesis, 2011)A set of mutants with inactivated genes encoding different parts of the butanolide system in Streptomyces coelicolor are cultivated in fermenters. We want to identify and characterize the signaling molecules, gamma- ... -
Mass Spectrometry-Based Metabolomics of JJN-3 Cells: Establishment of Sampling Method and Metabolic Profiling of Stress Response
Furuhaugen, Håvard (Master thesis, 2013)Cancer is a leading cause of death worldwide, and in the search of improved treatment efficacy and novel cancer treatments, the field of metabolomics has achieved much attention recent years. Metabolomics provides analysis ... -
Massespektrometri-basert analyse av metabolske endringer i en human embryonal nyrecellelinje som respons på kjemoterapeutisk behandling
Hestbråten, Camilla (Master thesis, 2014)I senere tid har det blitt oppdaget at flere proteiner tilknyttet genotoksisk stress binder til PCNA, et multifunksjonelt protein involvert i flere cellulære prosesser, gjennom et APIM-motiv. ATX-101 er et nylig utviklet ... -
Massespektrometri-basert metabolitt profilering av en human embryonal nyrecellelinje utsatt for cisplatin og det nye APIM-holdige peptidmedikamentet ATX-101.
Tokerud, Mari Orøy (Master thesis, 2014)Metabolomics, studien av metabolitter som opptrer i cellens biokjemiske nettverk, har blitt svært aktuelt innen kreftforskning for å kartlegge kreftcellers særegne metabolisme og utvikle nye spesifikke kreftbehandlingsmetoder. ... -
Metabolic analyses of stress response in a non-cancerous cell line exposed to Cisplatin and a novel PCNA-interacting motif
Andresen, Elisabeth F. (Master thesis, 2013)Several proteins involved in DNA-damage repair have been found to interact with the proliferating cell nuclear antigen (PCNA) through a novel PCNA-interacting motif, an amino acid sequence called the AlkB homologue 2 ... -
Metabolic Changes in Response to Cell Cycle Synchronization and Treatment with Chemotherapeutic Drugs: Targeted and Non-Targeted Mass Spectrometric Analysis of Human Cell Lines
Gyllensten Bjørnsen, Elisabeth (Master thesis, 2013)In life sciences, the rise of the omics-era the recent decades has greatly contributed to increased understanding of biological systems. The latest addition to the omics group is metabolomics ? the science that aims at ... -
Metabolic Profiling of Cisplatin and ATX-101 Induced Stress-responses in the Bladder Cancer Cell Line T24
Olsen, Silje Malene (Master thesis, 2016)Proliferating cell nuclear antigen (PCNA) is a protein central in many cellular processes through its numerous protein interaction partners. Recently, it has been shown that several proteins involved in stress related ... -
Metabolic Profiling of Escherichia coli BL21 During Recombinant Protein Production with Varying Expression Vector Characteristics
Everson, Nikalet (Master thesis, 2022)The production of recombinant proteins usingmicrobial cell factories such as Escherichia coli (E. coli) is both a high value industry and a growing area of interest for the field of metabolomics. While historical industrial ... -
Metabolic Profiling of Glucose-Fed Metabolically Active Resting Zymomonas mobilis Strains
Fuchino, Katsuya; Kalnenieks, Uldis; Rutkis, Reinis; Grube, Mara; Bruheim, Per (Peer reviewed; Journal article, 2020)Zymomonas mobilis is the most efficient bacterial ethanol producer and its physiology is potentially applicable to industrial-scale bioethanol production. However, compared to other industrially important microorganisms, ... -
Metabolic Profiling of Multiple Myeloma Cancer Cells During Exposure to Chemotherapeutic Drugs: A Study of the Effects of ATX-101
Megård, Anna (Master thesis, 2014)This thesis investigates the metabolomic stress response induced in JJN-3 cells treated with the cell-penetrating peptide ATX-A, the anti-cancer drug ATX-101, the chemotherapeutic drug cisplatin, and combinations of these ... -
Metabolic Profiling of the Glioblastoma Cell Line U-87 MG in Response to Hypoxia and HIF-1alpha Inhibitors
Zhevagin, Irina Brokke (Master thesis, 2020)Glioblastom er en krefttype med høy dødelighet, og dens dødelighet har sammenheng med graden av hypoksi. Hypoksi, fraværet av nok oksygenering av vev, vil aktivere en rekke tilpasninger som fører til økning i behandlingsresistens ... -
Metabolic Responses to Colistin Sulfate and Trimethoprim Perturbation in Escherichia coli K12 MG1655
Evensen, Nora Østli (Master thesis, 2022)Antibiotika er antibakterielle molekyler som brukes i behandling mot bakterieinfeksjoner, men grunnet overforbruk og feilbruk har antibiotikaresistens blitt et økende problem. Antibiotikaresistens regnes som en av de største ... -
Metabolic Stress Study of a Human Embryotic Kidney Cell Line exposed to Chemotherapeutic Drugs: Mass Spectrometry based Targeted and Non-targeted Approach
Larsen, Britt Elin (Master thesis, 2014)Metabolomics, the study of metabolites in a cell, has proven as an applicable approach in cancer research to investigate the altered metabolism of cancer cells and to develop new selective chemotherapeutic drugs. ATX-101 ... -
Metabolite profiling and kinetic modeling of antibiotic producing Streptomyces coelicolor in response to metabolic switching triggered by nutrient depletion
Singleton, Amanda Holstad (Master thesis, 2020)Rask framvekst av antibiotikaresistens i patogene bakteriar er ei global helsekrise. Handtering av denne krisa krev rask oppdaging og effektiv produksjon av nye antibiotiske biosyntetiske genklynger (BGC). Ein potensiell ... -
Metabolome Studies of Stress Responses in Saccharomyces Cerevisiae : - implementation of sampling and analytical protocols
Haug, Anne Marte (Master thesis, 2011)As a part of cancer research and therapy, it is important to study metabolic responses caused by DNA damaging agents. Whereas earlier studies have focused on changes at protein levels caused by DNA damaging agents, this ... -
Metabolsk Tilpasning til Hypoksi i Prostatakreftcellelinjen DU-145 og i Glioblastoma-Astrocytoma Kreftcellelinjen U-87 MG
Midtbust, Elise (Master thesis, 2017)Regioner med lav oxygentensjon (hypoksiske regioner) er karakteristisk for solide tumorer. Hypoksiske forhold fremkommer når den raske cellulære prolifereringen begrenser oksygentilgangen. Proteinkomplekset proliferating ... -
Methods and algorithms for the study of biomolecular networks
Martyushenko, Nikolay (Doctoral theses at NTNU;2019:179, Doctoral thesis, 2019)Living organisms play a crucial role in our lives, serving us as sources of food and materials. In order to effectively work with living organisms, we need to understand them. And we understand biological organisms by ... -
Molecular profiling of Ductal Carcinoma In Situ
Mørk, Hanne Håberg (Master thesis, 2012)Breast cancer develops through multiple stages from hyperplasia to invasive and finally metastatic disease. Ductal carcinoma in situ (DCIS) is an abnormal proliferation of epithelial cells within the milk ducts in the ...