Blar i NTNU Open på forfatter "Bruheim, Per"
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In Vitro Synthesis of Metabolites of three Anabolic Androgenic Steroids, by Human Liver Microsomes
Schjølberg, Tiril Helgesen (Master thesis, 2013)Anabolic androgenic steroids are substances frequently misused to improve physicalperformance in sports. To reveal substances misused as doping, athlete urinesamples are collected and tested. To identify the steroid and/or ... -
Increased Anticancer Efficacy of Intravesical Mitomycin C Therapy when combined with a PCNA Targeting Peptide
Gederaas, Odrun Arna; Søgaard, Caroline Danielsen; Viset, Trond; Bachke, Siri; Bruheim, Per; Arum, Carl-Jørgen; Otterlei, Marit (Journal article; Peer reviewed, 2014)Non–muscle-invasive bladder cancers (NMIBCs) are tumors confined to the mucosa or the mucosa/submucosa. An important challenge in treatment of NMIBC is both high recurrence and high progression rates. Consequently, more ... -
Increased salt tolerance in Zymomonas mobilis strain generated by adaptative evolution
Fuchino, Katsuya; Bruheim, Per (Peer reviewed; Journal article, 2020)Background Ethanologenic alphaproteobacterium Zymomonas mobilis has been acknowledged as a promising biofuel producer. There have been numerous efforts to engineer this species applicable for an industrial-scale bioethanol ... -
Insights into the genome-scale metabolic modelling framework based on Pseudomonas taiwanensis VLB120
Schulz, Christian (Doctoral theses at NTNU;2021:153, Doctoral thesis, 2021)Any living organism - complex or single-cell - consists of multiple layers of inter connected components. This starts on an atomic scale all the way through enzymes and cells, and in some cases organs, to make up organisms, ... -
Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod
Eide, Marta; Goksøyr, Anders; Yadetie, Fekadu; Gilabert, Alejandra; Bartosova, Zdenka; Frøysa, Håvard Guldbrandsen; Fallahi, Shirin; Zhang, Xiaokang; Blaser, Nello; Jonassen, Inge; Bruheim, Per; Alendal, Guttorm; Brun, Morten; Porte, Cinta; Karlsen, Odd André (Peer reviewed; Journal article, 2023)Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, the peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in ... -
Intracellular metabolite pool changes in response to nutrient depletion induced metabolic switching in Streptomyces coelicolor
Wentzel, Alexander; Sletta, Håvard; Wellington, E.M.H.; Ellingsen, Trond Erling; Bruheim, Per (Journal article; Peer reviewed, 2012)Abstract: A metabolite profiling study of the antibiotic producing bacterium Streptomyces coelicolor A3(2) has been performed. The aim of this study was to monitor intracellular metabolite pool changes occurring as strains ... -
Investigating the Role of Stress Responses in Escherichia coli in Persister Formation through Persister Quantification of relA and rpoS null mutants
Trømborg, Åsne Skram (Master thesis, 2021)Bakterier som overlever behandling med antimikrobielle stoffer, er et økende, globalt problem og er estimert å kunne bli årsaken til 10 millioner dødsfall innen 2050 om dagens trend, med høy bruk og lav utvikling av ... -
Investigation of Three Novel MEN1 Mutations - A Cell-Based Functional Study
Hamnvik, Berit G. (Master thesis, 2020) -
Isolation and cultivation of primary muscle cells from Lobster (Homarus gammarus)
Jang, Mi; Scheffold, Jana; Bruheim, Per (Peer reviewed; Journal article, 2022) -
Isolation and genotypic characterization of different yeast strains from Nepalese mixed culture (Murcha)
Bhusal, Kshitiz (Master thesis, 2017)14 different yeast strains were isolated from the Nepalese yeast cakes (murcha) of six different places varying in geographical condition. The isolation was entirely random based on the morphologies of the colonies, were ... -
Large dependency of intracellular NAD and CoA pools on cultivation conditions in Saccharomyces cerevisiae
Kumar, Kanhaiya; Bruheim, Per (Journal article; Peer reviewed, 2021) -
Lipid accumulation in docohexaenoic acid producing Aurantiochytrium sp. strain T66
Tronsaune, Simen Liberg (Master thesis, 2018)Docohexaenoic acid (DHA), one of the omega-3 fatty acids, is an essential nutrient for human, animal and fish health. The DHA production from fish oil resources is associated with several negative features, and microbial ... -
Localization and Function of Factor XIII at the Fetal-Uterine Interface: Recurrent Abortion Management Issues
Syslak, Line (Master thesis, 2012)The blood coagulation Factor XIII (FXIII) is a transglutaminase catalyzing γ-glytamyl ε-lysine crosslinks between various molecules. It is most known for its role in crosslinking fibrin and stabilizing the blood clot in ... -
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling
Borgos, Sven Even F.; Bordel, Sergio; Sletta, Håvard; Ertesvåg, Helga; Jakobsen, Øyvind Mejdell; Bruheim, Per; Ellingsen, Trond Erling; Nielsen, Jens; Valla, Svein (Journal article; Peer reviewed, 2013)Background: Alginate is an industrially important polysaccharide, currently produced commercially by harvesting of marine brown sea-weeds. The polymer is also synthesized as an exo-polysaccharide by bacteria belonging to ... -
Mass Spectrometric Metabolic Profiling of Bladder Cancer Cell Line T24 under Cisplatin and APIM-peptide Stress
Fjørtoft, Marit Otterlei (Master thesis, 2016)The hub protein proliferating cell nuclear antigen (PCNA) is involved in several important cellular processes. During conditions of genotoxic stress, PCNA binds to proteins containing AlkB homologue 2 PCNA-interacting motif ... -
Mass Spectrometric Metabolic Profiling of Human Cells during Cell Cycle and Cytostatic Treatment.
Hole, Nina Lillebø (Master thesis, 2013)This project had to different objectives. The first goal was to study the metabolite pool of the cell lines HaCaT and DU145 in the different cell phases in the cell cycle. To obtain this data, the cell lines had to be ... -
Mass Spectrometric Metabolic Profiling of the Human Bladder Cancer Cell Line UM-UC-3 under Cytostatic Stress
Forsland, Yngve (Master thesis, 2016)Muscle Invasive Bladder Cancers (MIBCs) contributes to approximately 30% of bladder cancer at initial diagnosis in patients, accompanied by an only 50% five-year survival rate. The standard procedure for treating this type ... -
Mass Spectrometric Metabolic Profiling of the Multiple Myeloma Cell Line JJN-3 under APIM-peptide Stress
Røst, Lisa Marie (Master thesis, 2015)The proliferating cell nuclear antigen (PCNA) is recognized as a hub protein, central to maintaining cellular homeostasis through its numerous protein interaction partners. Under conditions of genotoxic stress, there is ... -
Mass Spectrometric Metabolic Profiling of the Prostate Cancer Cell Line DU-145 and the Glioblastoma Astrocytoma Cell Line U-87 MG Under Hypoxic Stress
Brinch, Ulrikke Dahl (Master thesis, 2017)Hypoxia is a condition of mild oxygen (O2) deficiency and is observed in most solid tumors. It is believed to trigger malignant transformation, alter metabolism, and it contributes to, for example, metastasis, invasiveness, ... -
Mass Spectrometrical Analysis in Lipidomics
Mainali, Anushree (Master thesis, 2020)Lipider representerer over femti tusen arter av biomolekyler med et like stort utvalg av biologiske funksjoner. De fungerer som den viktigste strukturelle komponenten i forskjellige biologiske membraner, som store aktører ...