Blar i NTNU Open på tittel
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In vitro differentiation of osteoclasts - Studying the effect of myeloma derived immunoglobulins on osteoclastogenesis after optimizing the culturing process
(Master thesis, 2016)Multiple myeloma is a hematological cancer caused by accumulation of malignant plasma cells in the bone marrow with extensive bone destruction and heavily decreased bone formation. Osteoclasts are terminally differentiated, ... -
In vitro effects of radiation and mechanical load on murine osteocytes MLO-Y4
(Master thesis, 2020)The increased survival rates for cancer as a result of improved diagnosis and treatment has come with the drawback that cancer treatment side effects are becoming more frequent as well. Cancer treatment induced bone loss ... -
In vitro effects of the AMP-activated protein kinase agonist metformin on murine osteocytes MLO-Y4
(Master thesis, 2020)Osteoporose er en skjelettsykdom som gir økt risiko for beinbrudd. Sykdommen karakteriseres av nedsatt beinkvalitet og lav beinmasse, og er en økende bekymring grunnet en økt aldrende befolkning. Styrketrening er vist å ... -
In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model
(Peer reviewed; Journal article, 2023)Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings. Upon systemic administration, however, they are rapidly recognized by components of innate immunity, which limit their therapeutic ... -
In vitro Inhibition of CYP3A4 by VitaePro
(Master thesis, 2016)Introduction and aims: There has been an almost exponential growth within the nutritional supplement industry, and along with this, an increasing number of reported interactions between supplements and prescribed drugs ... -
In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport
(Doktoravhandlinger ved NTNU, 1503-8181; 2007:256, Doctoral thesis, 2007)Omsetningen av naturlegemidler og kosttilskudd har økt dramatisk de siste årene, og en økende aksept for urtebruk tilsier at forbruket fortsatt vil øke. Samtidig bruk av naturlegemidler/urter og legemidler forekommer ofte. ... -
In Vitro Setup for Coronary Circulation with Ventricular Motion
(Master thesis, 2017)Blood and tissue motion can be detected using Doppler ultrasound. However, in a complex system such as the human body, the blood is not the only matter in motion. Doppler signals reflected by blood are often disturbed by ... -
In vitro studies of DNA condensation by bridging protein in a crowding environment
(Journal article; Peer reviewed, 2017)The macromolecules of the bacterial cell occupy 20–40% of the total cytosol volume, and crowded environments have long been known to compact and stabilize DNA. Nevertheless, investigations on DNA-protein binding are generally ... -
In vitro studies of ROR1 knockdown effects in hypoxic prostate cancer cells
(Master thesis, 2023)Bakgrunn: De fleste kreftsvulster inneholder hypoksiske områder, som er assosiert med resistans mot kreftbehandling og dårlig prognose. Kobber-64 (Cu-64) radiofarmaka har vokst frem som et teranostisk legemiddel i onkologi, ... -
In Vitro Synthesis of Metabolites of three Anabolic Androgenic Steroids, by Human Liver Microsomes
(Master thesis, 2013)Anabolic androgenic steroids are substances frequently misused to improve physicalperformance in sports. To reveal substances misused as doping, athlete urinesamples are collected and tested. To identify the steroid and/or ... -
In vitro validation of anticancer drug combinations on colon cancer cell lines SW620 and HCT116
(Master thesis, 2018)Combinatory drug treatment, e.g. targeting different proteins in specific signaling pathways tailored to an individual’s tumor, is expected to overcome problems related to individual variation in drug efficacy, resistance ... -
In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts
(Journal article; Peer reviewed, 2015)Purpose To study cancer associated with abnormal metabolism of phospholipids, of which several have been proposed as biomarkers for malignancy or to monitor response to anticancer therapy. We explored 3D 31P magnetic ... -
In Vivo Analysis of a Biodegradable Magnesium Alloy Implant in an Animal Model Using Near-Infrared Spectroscopy
(Peer reviewed; Journal article, 2023)Biodegradable Magnesium (Mg) based implants have several advantages over non-biodegradable metallic implants as they have mechanical properties close to the natural bone. Monitoring the interaction of magnesium with tissue ... -
In Vivo Analysis of a Biodegradable Magnesium Alloy Implant in an Animal Model Using Near-Infrared Spectroscopy
(Peer reviewed; Journal article, 2023)Biodegradable magnesium-based implants offer mechanical properties similar to natural bone, making them advantageous over nonbiodegradable metallic implants. However, monitoring the interaction between magnesium and tissue ... -
In vivo comparison of boned ensitometry
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In vivo intracardiac vector flow imaging using phased array transducers for pediatric cardiology
(Journal article; Peer reviewed, 2017)Two-dimensional blood speckle tracking (ST) has shown promise for measuring complex flow patterns in neonatal hearts using linear arrays and high-frame-rate plane wave imaging. For general pediatric applications, however, ... -
In vivo Magnetic Resonance Spectroscopy and Diffusion Weighted Magnetic Resonance Imaging for Non-Invasive Monitoring of Treatment Response of Subcutaneous HT29 Xenografts in Mice
(Master thesis, 2006)This work investigates whether in vivo magnetic resonance spectroscopy (MRS) and diffusion-weighted magnetic resonance imaging (DW-MRI) can be used for non-invasive monitoring of treatment response in an experimental tumor ... -
In Vivo Microdialysis in Mice Captures Changes in Alzheimer´s Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology
(Peer reviewed; Journal article, 2021)Background: Preclinical models of Alzheimer’s disease (AD) can provide valuable insights into the onset and progression of the disease, such as changes in concentrations of amyloid-β (Aβ) and tau in cerebrospinal fluid ... -
In what ways do emerging adults with substance use problems experience their communities as influencing their personal recovery processes?
(Peer reviewed; Journal article, 2022)Applying the multiple psychological sense of community concept (MPSOC), this study explored how emerging adults with substance use problems experience the influences of various senses of community and communities on their ...