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dc.contributor.authorArnesen, Carl-Arne
dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorHveem, Kristian
dc.contributor.authorGabrielsen, Maiken Elvestad
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.date.accessioned2024-07-31T08:54:03Z
dc.date.available2024-07-31T08:54:03Z
dc.date.created2024-03-15T14:39:55Z
dc.date.issued2024
dc.identifier.citationResearch and Practice in Thrombosis and Haemostasis (RPTH). 2024, 8 (2), .en_US
dc.identifier.issn2475-0379
dc.identifier.urihttps://hdl.handle.net/11250/3143823
dc.description.abstractBackground Data on the proportion of venous thromboembolism (VTE) risk attributed to prothrombotic genotypes in men and women are limited. Objectives We aimed to estimate the population attributable fraction (PAF) of VTE for recognized, common prothrombotic genotypes in men and women using a population-based case cohort. Methods Cases with incident VTE (n = 1493) and a randomly sampled subcohort (n = 13,069) were derived from the Tromsø study (1994-2012) and the Trøndelag Health Study (1995-2008) cohorts. DNA samples were genotyped for 17 single-nucleotide polymorphisms (SNPs) previously associated with VTE. PAFs with 95% bias-corrected CIs (based on 10,000 bootstrap samples) were estimated for SNPs significantly associated with VTE, and a 6-SNP cumulative model was constructed for both sexes. Results In women, the individual PAFs for SNPs included in the cumulative model were 16.9% for ABO (rs8176719), 17.6% for F11 (rs2036914), 15.1% for F11 (rs2289252), 8.7% for FVL (rs6025), 6.0% for FGG (rs2066865), and 0.2% for F2 (rs1799963). The cumulative PAF for this 6-SNP model was 37.8%. In men, the individual PAFs for SNPs included in the cumulative model were 21.3% for ABO, 12.2% for F11 (rs2036914), 10.4% for F11 (rs2289252), 7.5% for FVL, 7.8% for FGG, and 1.1% for F2. This resulted in a cumulative PAF in men of 51.9%. Conclusion Our findings in a Norwegian population suggest that 52% and 38% of the VTEs can be attributed to known prothrombotic genotypes in men and women, respectively.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleProportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and womenen_US
dc.title.alternativeProportion of venous thromboembolism attributed to recognized prothrombotic genotypes in men and womenen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.source.volume8en_US
dc.source.journalResearch and Practice in Thrombosis and Haemostasis (RPTH)en_US
dc.source.issue2en_US
dc.identifier.doi10.1016/j.rpth.2024.102343
dc.identifier.cristin2254935
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal