dc.contributor.author | Lång, Emma Helena | |
dc.contributor.author | Lång, Anna Ulrika | |
dc.contributor.author | Blicher, Pernille | |
dc.contributor.author | Rognes, Torbjørn | |
dc.contributor.author | Dommersnes, Paul Gunnar | |
dc.contributor.author | Bøe, Stig Ove | |
dc.date.accessioned | 2024-04-24T08:23:59Z | |
dc.date.available | 2024-04-24T08:23:59Z | |
dc.date.created | 2024-04-18T08:40:09Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Science Advances. 2024, 10 (16), 1-14. | en_US |
dc.identifier.issn | 2375-2548 | |
dc.identifier.uri | https://hdl.handle.net/11250/3127868 | |
dc.description.abstract | The ability of epithelial monolayers to self-organize into a dynamic polarized state, where cells migrate in a uniform direction, is essential for tissue regeneration, development, and tumor progression. However, the mechanisms governing long-range polar ordering of motility direction in biological tissues remain unclear. Here, we investigate the self-organizing behavior of quiescent epithelial monolayers that transit to a dynamic state with long-range polar order upon growth factor exposure. We demonstrate that the heightened self-propelled activity of monolayer cells leads to formation of vortex-antivortex pairs that undergo sequential annihilation, ultimately driving the spread of long-range polar order throughout the system. A computational model, which treats the monolayer as an active elastic solid, accurately replicates this behavior, and weakening of cell-to-cell interactions impedes vortex-antivortex annihilation and polar ordering. Our findings uncover a mechanism in epithelia, where elastic solid material characteristics, activated self-propulsion, and topology-mediated guidance converge to fuel a highly efficient polar self-ordering activity. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American Association for the Advancement of Science | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Topology-guided polar ordering of collective cell migration | en_US |
dc.title.alternative | Topology-guided polar ordering of collective cell migration | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 1-14 | en_US |
dc.source.volume | 10 | en_US |
dc.source.journal | Science Advances | en_US |
dc.source.issue | 16 | en_US |
dc.identifier.doi | 10.1126/sciadv.adk4825 | |
dc.identifier.cristin | 2262540 | |
dc.relation.project | Norges forskningsråd: Ukjent | en_US |
dc.relation.project | Helse Sør-Øst RHF: Ukjent | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |