dc.contributor.author | Wang, Yining | |
dc.contributor.author | Li, Pengfei | |
dc.contributor.author | Xu, Lei | |
dc.contributor.author | de Vries, Annemarie C. | |
dc.contributor.author | Rottier, Robbert J. | |
dc.contributor.author | Wang, Wenshi | |
dc.contributor.author | Crombag, Marie-Rose B.S. | |
dc.contributor.author | Peppelenbosch, Maikel P. | |
dc.contributor.author | Kaynov, Denis | |
dc.contributor.author | Pan, Qiuwei | |
dc.date.accessioned | 2024-02-29T08:55:44Z | |
dc.date.available | 2024-02-29T08:55:44Z | |
dc.date.created | 2023-09-08T13:19:18Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | iScience. 2023, 26 (9), . | en_US |
dc.identifier.issn | 2589-0042 | |
dc.identifier.uri | https://hdl.handle.net/11250/3120400 | |
dc.description.abstract | Severe infections with coronaviruses are often accompanied with hyperinflammation, requiring therapeutic strategies to simultaneously tackle the virus and inflammation. By screening a safe-in-human broad-spectrum antiviral agents library, we identified that indomethacin can inhibit pan-coronavirus infection in human cell and airway organoids models. Combining indomethacin with oral antiviral drugs authorized for treating COVID-19 results in synergistic anti-coronavirus activity. Coincidentally, screening a library of FDA-approved drugs identified indomethacin as the most potent potentiator of interferon response through increasing STAT1 phosphorylation. Combining indomethacin with interferon-alpha exerted synergistic antiviral effects against multiple coronaviruses. The anti-coronavirus activity of indomethacin is associated with activating interferon response. In a co-culture system of lung epithelial cells with macrophages, indomethacin inhibited both viral replication and inflammatory response. Collectively, indomethacin is a pan-coronavirus inhibitor that can simultaneously inhibit virus-triggered inflammatory response. The therapeutic potential of indomethacin can be further augmented by combining it with oral antiviral drugs or interferon-alpha. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response | en_US |
dc.title.alternative | Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 0 | en_US |
dc.source.volume | 26 | en_US |
dc.source.journal | iScience | en_US |
dc.source.issue | 9 | en_US |
dc.identifier.doi | 10.1016/j.isci.2023.107631 | |
dc.identifier.cristin | 2173522 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |