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dc.contributor.authorPiarulli, Stefania
dc.contributor.authorRiedel, Juliane Annemieke
dc.contributor.authorFossum, Frida Nonstad
dc.contributor.authorKermen, Florence
dc.contributor.authorHansen, Bjørn Henrik
dc.contributor.authorKvæstad, Bjarne
dc.contributor.authorOlsvik, Pål Asgeir
dc.contributor.authorFarkas, Julia
dc.date.accessioned2024-02-06T14:46:24Z
dc.date.available2024-02-06T14:46:24Z
dc.date.created2024-01-08T16:02:34Z
dc.date.issued2023
dc.identifier.issn0045-6535
dc.identifier.urihttps://hdl.handle.net/11250/3116012
dc.description.abstractGadolinium (Gd) is one of the rare earth elements (REY) and is widely used in magnetic resonance imaging (MRI) contrast agents. Anthropogenic Gd enrichment has frequently been found in wastewater treatment plant effluents in industrialised countries, rising concerns regarding effects on aquatic biota. This study investigates the acute toxicity and sublethal effects of Gd in two forms, as inorganic salt (GdCl3) and as Gd-based contrast agent (GBCA), on early life stages of zebrafish (Danio rerio). Nominal exposure concentrations ranged from 3 to 3000 μg L−1, with an exposure duration of 96 h. None of the two tested compounds were acutely toxic to embryos and larvae. Similarly, we did not observe any effects on larval development and locomotive behaviour. However, we found significant changes in the brain activity of larvae exposed to the highest concentrations of GdCl3 and the GBCA. Our findings show that Gd can have sublethal effects on developing fish at lower concentrations than reported previously, highlighting the necessity of investigating the long-term fate and effects of GBCAs released into the aquatic environment.en_US
dc.language.isoengen_US
dc.publisherElsevier B. V.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleEffects of gadolinium (Gd) and a Gd-based contrast agent (GBCA) on early life stages of zebrafish (Danio rerio)en_US
dc.title.alternativeEffects of gadolinium (Gd) and a Gd-based contrast agent (GBCA) on early life stages of zebrafish (Danio rerio)en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.volume350en_US
dc.source.journalChemosphereen_US
dc.identifier.doi10.1016/j.chemosphere.2023.140950
dc.identifier.cristin2222588
dc.relation.projectNorges forskningsråd: 301236en_US
dc.relation.projectNorges forskningsråd: 262698en_US
dc.source.articlenumber140950en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal