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dc.contributor.authorXie, Chuan
dc.contributor.authorXiong, Qinqin
dc.contributor.authorWei, Yuanzhi
dc.contributor.authorLi, Xin
dc.contributor.authorHu, Jiajun
dc.contributor.authorHe, Min
dc.contributor.authorWei, Shinan
dc.contributor.authorYu, Jia
dc.contributor.authorCheng, Sha
dc.contributor.authorAhmad, Mashaal
dc.contributor.authorLiu, Yufei
dc.contributor.authorLuo, Sihai
dc.contributor.authorZeng, Xi
dc.contributor.authorYu, Jie
dc.contributor.authorLuo, Heng
dc.date.accessioned2023-09-14T10:37:58Z
dc.date.available2023-09-14T10:37:58Z
dc.date.created2023-04-25T09:13:51Z
dc.date.issued2023
dc.identifier.citationMaterials Today Bio. 2023, 20 .en_US
dc.identifier.issn2590-0064
dc.identifier.urihttps://hdl.handle.net/11250/3089405
dc.description.abstractSustained drug release has attracted increasing interest in targeted drug therapy. However, existing methods of drug therapy suffer drug action time, large fluctuations in the effective concentration of the drug, and the risk of side effects. Here, a biodegradable composite of polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting of electrospun hollow microspheres as sustained-released drug carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate and drug (Erlotinib) release than that of PBAT. Furthermore, PBAT/PVP composites loaded with Erlotinib provide sustained release effect, thus achieving a better efficacy than that after the direct injection of erlotinib due to the fact that the composites allow a high drug concentration in the tumor for a longer period. Hence, this work provides a potential effective solution for clinical drug therapy and tissue engineering using drug microspheres with a sustained release.en_US
dc.language.isoengen_US
dc.publisherElsevier B. V.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleFabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained releaseen_US
dc.title.alternativeFabrication of biodegradable hollow microsphere composites made of polybutylene adipate co-terephthalate/polyvinylpyrrolidone for drug delivery and sustained releaseen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.volume20en_US
dc.source.journalMaterials Today Bioen_US
dc.identifier.doi10.1016/j.mtbio.2023.100628
dc.identifier.cristin2143052
dc.source.articlenumber100628en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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