Background: Breast cancer is the most commonly diagnosed cancer worldwide, accounting for 12.5% of all new annual cases. Most of these patients will have to undergo chemotherapy as a treatment method and will, consequently, suffer from side effects during and/or after finished treatment. Despite the high prevalence of complications experienced by breast cancer patients, there is limited research conducted on how to prevent or limit them. When looking into the effect of resistance training on fatigue as a side effect of chemotherapy, there is insufficient research. The aim of this literature review study is to investigate if resistance training has any effect on reduction of fatigue for breast cancer patients undergoing chemotherapy. Methods: The systematic literature search was conducted using the PubMed database. Relevant literature was identified using search criteria including patients with breast cancer undergoing chemotherapy, resistance training program and measured fatigue. The included studies had to be randomized controlled trials or clinical trials. Results: Eight original papers were included in this literature study. Seven out of eight studies found an indication that exercise, including resistance training, had a significant effect on cancer-related fatigue. Conclusion: This literature review study suggested that the effect of resistance training on reduction of fatigue among patients with breast cancer undergoing chemotherapy was promising.