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dc.contributor.authorSuica, Viorel I.
dc.contributor.authorUyy, Elena
dc.contributor.authorIvan, Luminita
dc.contributor.authorBoteanu, Raluca M.
dc.contributor.authorCerveanu-Hogas, Aurel
dc.contributor.authorHansen, Rune
dc.contributor.authorAntohe, Felicia
dc.date.accessioned2023-03-02T10:06:10Z
dc.date.available2023-03-02T10:06:10Z
dc.date.created2022-10-28T12:29:06Z
dc.date.issued2022
dc.identifier.citationInternational Journal of Molecular Sciences. 2022, 23 (19), .en_US
dc.identifier.issn1661-6596
dc.identifier.urihttps://hdl.handle.net/11250/3055253
dc.description.abstractIncreased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. We hypothesize that a specific panel of stress-sensing molecules (alarmins) could indicate the persistence of silent atherosclerosis residual risk. New Zealand White rabbits were divided into: control group (C), a group that received a high-fat diet for twelve weeks (Au), and a treated hyperlipidemic group with a lipid diet for eight weeks followed by a standard diet and hypolipidemic treatment (atorvastatin and PCSK9 siRNA-inhibitor) for four weeks (Asi). Mass spectrometry experiments of left ventricle lysates were complemented by immunologic and genomic studies to corroborate the data. The hyperlipidemic diet determined a general alarmin up-regulation tendency over the C group. A significant spectral abundance increase was measured for specific heat shock proteins, S100 family members, HMGB1, and Annexin A1. The hypolipidemic treatment demonstrated a reversed regulation trend with non-significant spectral alteration over the C group for some of the identified alarmins. Our study highlights the discriminating potential of alarmins in hyperlipidemia or following hypolipidemic treatment. Data are available via ProteomeXchange with identifier PXD035692.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapyen_US
dc.title.alternativeCardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber16en_US
dc.source.volume23en_US
dc.source.journalInternational Journal of Molecular Sciencesen_US
dc.source.issue19en_US
dc.identifier.doi10.3390/ijms231911174
dc.identifier.cristin2065997
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal