dc.contributor.author | Troøyen, Susanne Hansen | |
dc.contributor.author | Jacobsen, Elisabeth Egholm | |
dc.date.accessioned | 2023-02-15T09:58:50Z | |
dc.date.available | 2023-02-15T09:58:50Z | |
dc.date.created | 2023-01-05T13:06:07Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Catalysts. 2022, 12 (12), . | en_US |
dc.identifier.issn | 2073-4344 | |
dc.identifier.uri | https://hdl.handle.net/11250/3050994 | |
dc.description.abstract | The β-blocker (S)-betaxolol has been synthesized in 99% enantiomeric excess (ee) from the commercially available precursor 4-(2-hydroxyethyl)phenol. The racemic chlorohydrin 1-chloro-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol was esterified with vinyl acetate catalyzed by lipase B from Candida antarctica, which gave the R-chlorhydrin (R)-1-chloro-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol in 99% ee with 38% yield. The enantiomeric excess of the R-chlorohydrin was retained in an amination reaction with isopropylamine in methanol to yield (S)-betaxolol in 99% ee and with 9% overall yield. We are under way to improve the yield. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (S)-Betaxolol | en_US |
dc.title.alternative | Chemo-Enzymatic Synthesis of Enantiopure β-Antagonist (S)-Betaxolol | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 0 | en_US |
dc.source.volume | 12 | en_US |
dc.source.journal | Catalysts | en_US |
dc.source.issue | 12 | en_US |
dc.identifier.doi | 10.3390/catal12121645 | |
dc.identifier.cristin | 2101293 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |