dc.contributor.author | Lindholm, Håvard Takle | |
dc.contributor.author | Parmar, Naveen | |
dc.contributor.author | Drurey, Claire | |
dc.contributor.author | Poveda, Marta Campillo | |
dc.contributor.author | Vornewald, Pia | |
dc.contributor.author | Ostrop, Jenny | |
dc.contributor.author | Sanchez, Alberto Diez | |
dc.contributor.author | Maizels M, Rick | |
dc.contributor.author | Oudhoff, Menno | |
dc.date.accessioned | 2023-02-07T11:40:03Z | |
dc.date.available | 2023-02-07T11:40:03Z | |
dc.date.created | 2022-07-06T21:06:47Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2470-9468 | |
dc.identifier.uri | https://hdl.handle.net/11250/3048854 | |
dc.description.abstract | Intestinal parasite infections or allergic reactions promote IL-13–induced differentiation of tuft cells as one manifestation of type 2 immunity in the gut. Using organoid cultures of intestinal epithelial cells, Lindholm et al. investigated how the lymphocyte cytokines IL-13, IL-22, and IFNγ regulate the signaling pathways that influence epithelial differentiation. While tuft cell IL-25 promoted expansion of IL-13–producing ILC2s in a feed-forward loop, the resulting IL-13 also induced ligands of the bone morphogenetic protein (BMP) signaling pathway. BMP agonists acted on stem cells to prevent runaway tuft cell expansion by limiting expression of Sox4, a transcription factor required for tuft cell differentiation. These findings provide new molecular insights into how intestinal epithelial differentiation is carefully choreographed in response to a diverse array of cytokine signals. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American Association for the Advancement of Science | en_US |
dc.title | BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia | en_US |
dc.title.alternative | BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2023 American Association for the Advancement of Science | en_US |
dc.source.volume | 7 | en_US |
dc.source.journal | Science immunology | en_US |
dc.source.issue | 71 | en_US |
dc.identifier.doi | 10.1126/sciimmunol.abl6543 | |
dc.identifier.cristin | 2037429 | |
dc.relation.project | Norges forskningsråd: 274760 | en_US |
dc.relation.project | Kreftforeningen: 182767 | en_US |
dc.relation.project | Norges forskningsråd: 223255 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |