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dc.contributor.authorDalsgaard, Sofie Bünemann
dc.contributor.authorWürtz, Else Toft
dc.contributor.authorHansen, Johnni
dc.contributor.authorRøe, Oluf Dimitri
dc.contributor.authorOmland, Øyvind
dc.date.accessioned2023-02-02T09:47:14Z
dc.date.available2023-02-02T09:47:14Z
dc.date.created2022-04-28T14:10:39Z
dc.date.issued2022
dc.identifier.citationInternational Journal of Environmental Research and Public Health (IJERPH). 2022, 19 (4), .en_US
dc.identifier.issn1661-7827
dc.identifier.urihttps://hdl.handle.net/11250/3047937
dc.description.abstractObjectives: To examine the risk of cancer in former school children exposed to environmental asbestos in childhood with a focus on female cancers, including breast cancer. Methods: We retrieved a cohort of females (n = 6024) attending four schools located in the neighborhood of a large asbestos cement plant in Denmark. A reference cohort was frequency-matched 1:9 (n = 54,200) in sex and five-year age intervals. Using Danish registries, we linked information on historical employments, relatives’ employments, cancer, and vital status. We calculated standardized incidence rates (SIRs) for all and specific cancers, comparing these rates with the reference cohort. Hazard ratios were calculated for selected cancers adjusted for occupational and familial asbestos exposure. Results: For cancer of the corpus uteri (SIR 1.29, 95% CI 1.01–1.66) and malignant mesothelioma (SIR 7.26, 95% CI 3.26–16.15), we observed significantly increased incidences. Occupationally, asbestos exposure had a significantly increased hazard ratio for cancer in the cervix, however, a significantly lower risk of ovarian cancer. The overall cancer incidence was similar to that of the reference cohort (SIR 1.02, 95% CI 0.96–1.07). The risk of cancer of the lung was increased for those exposed to occupational asbestos, those with family members occupationally exposed to asbestos and for tobacco smokers. Conclusions: In our study, environmental asbestos exposure in childhood is associated with an increased risk of cancer of the corpus uteri and malignant mesothelioma in women.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleA Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Canceren_US
dc.title.alternativeA Cohort Study on Cancer Incidence among Women Exposed to Environmental Asbestos in Childhood with a Focus on Female Cancers, including Breast Canceren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber11en_US
dc.source.volume19en_US
dc.source.journalInternational Journal of Environmental Research and Public Health (IJERPH)en_US
dc.source.issue4en_US
dc.identifier.doi10.3390/ijerph19042086
dc.identifier.cristin2019833
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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