EEG-derived brain graphs are reliable measures for exploring exercise-induced changes in brain networks

Abstract

The interaction of acute exercise and the central nervous system evokes increasing interest in interdisciplinary research fields of neuroscience. Novel approaches allow to monitor large-scale brain networks from mobile electroencephalography (EEG) applying graph theory, but it is yet uncertain whether brain graphs extracted after exercise are reliable. We therefore aimed to investigate brain graph reliability extracted from resting state EEG data before and after submaximal exercise twice within one week in male participants. To obtain graph measures, we extracted global small-world-index (SWI), clustering coefficient (CC) and characteristic path length (PL) based on weighted phase leg index (wPLI) and spectral coherence (Coh) calculation. For reliability analysis, Intraclass-Correlation-Coefficient (ICC) and Coefficient of Variation (CoV) were computed for graph measures before (REST) and after POST) exercise. Overall results revealed poor to excellent measures at PRE and good to excellent ICCs at POST in the theta, alpha-1 and alpha-2, beta-1 and beta-2 frequency band. Based on bootstrap-analysis, a positive effect of exercise on reliability of wPLI based measures was observed, while exercise induced a negative effect on reliability of Coh-based graph measures. Findings indicate that brain graphs are a reliable tool to analyze brain networks in exercise contexts, which might be related to the neuroregulating effect of exercise inducing functional connections within the connectome. Relative and absolute reliability demonstrated good to excellent reliability after exercise. Chosen graph measures may not only allow analysis of acute, but also longitudinal studies in exercise-scientific contexts.