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dc.contributor.authorYang, Jae Jeong
dc.contributor.authorYu, Danxia
dc.contributor.authorWhite, Emily
dc.contributor.authorLee, Dong Hoon
dc.contributor.authorBlot, William
dc.contributor.authorRobien, Kim
dc.contributor.authorSinha, Rashmi
dc.contributor.authorPark, Yikyung
dc.contributor.authorTakata, Yumie
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorSmith-Byrne, Karl
dc.contributor.authorMonninkhof, Evelyn M
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorBorch, Kristin Benjaminsen
dc.contributor.authorAl-Shaar, Laila
dc.contributor.authorLan, Qing
dc.contributor.authorSørgjerd, Elin Pettersen
dc.contributor.authorZhang, Xuehong
dc.contributor.authorZhu, Clair
dc.contributor.authorChirlaque, María Dolores
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorOvervad, Kim
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorAune, Dagfinn
dc.contributor.authorJohansson, Mattias
dc.contributor.authorSmith-Warner, Stephanie A
dc.contributor.authorZheng, Wei
dc.contributor.authorShu, Xiao-Ou
dc.date.accessioned2023-01-19T07:46:10Z
dc.date.available2023-01-19T07:46:10Z
dc.date.created2022-09-19T14:13:34Z
dc.date.issued2022
dc.identifier.citationJNCI Cancer Spectrum. 2022, 6 (2), .en_US
dc.identifier.issn2515-5091
dc.identifier.urihttps://hdl.handle.net/11250/3044443
dc.description.abstractBackground Little is known about the association between physical activity before cancer diagnosis and survival among lung cancer patients. In this pooled analysis of 11 prospective cohorts, we investigated associations of prediagnosis leisure-time physical activity (LTPA) with all-cause and lung cancer–specific mortality among incident lung cancer patients. Methods Using self-reported data on regular engagement in exercise and sports activities collected at study enrollment, we assessed metabolic equivalent hours (MET-h) of prediagnosis LTPA per week. According to the Physical Activity Guidelines for Americans, prediagnosis LTPA was classified into inactivity, less than 8.3 and at least 8.3 MET-h per week (the minimum recommended range). Cox regression was used to estimate hazard ratios (HRs) and 95% confidence interval (CIs) for all-cause and lung cancer–specific mortality after adjustment for major prognostic factors and lifetime smoking history. Results Of 20 494 incident lung cancer patients, 16 864 died, including 13 596 deaths from lung cancer (overall 5-year relative survival rate = 20.9%, 95% CI = 20.3% to 21.5%). Compared with inactivity, prediagnosis LTPA of more than 8.3 MET-h per week was associated with a lower hazard of all-cause mortality (multivariable-adjusted HR = 0.93, 95% CI = 0.88 to 0.99), but not with lung cancer–specific mortality (multivariable-adjusted HR = 0.99, 95% CI = 0.95 to 1.04), among the overall population. Additive interaction was found by tumor stage (Pinteraction = .008 for all-cause mortality and .003 for lung cancer–specific mortality). When restricted to localized cancer, prediagnosis LTPA of at least 8.3 MET-h per week linked to 20% lower mortality: multivariable-adjusted HRs were 0.80 (95% CI = 0.67 to 0.97) for all-cause mortality and 0.80 (95% CI = 0.65 to 0.99) for lung cancer–specific mortality. Conclusions Regular participation in LTPA that met or exceeded the minimum Physical Activity Guidelines was associated with reduced hazards of mortality among lung cancer patients, especially those with early stage cancer.en_US
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titlePrediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohortsen_US
dc.title.alternativePrediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohortsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber0en_US
dc.source.volume6en_US
dc.source.journalJNCI Cancer Spectrumen_US
dc.source.issue2en_US
dc.identifier.doi10.1093/jncics/pkac009
dc.identifier.cristin2053152
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal