Inflammation in the early phase after kidney transplantation is associated with increased long-term all-cause mortality
Heldal, Torbjørn Fossum; Åsberg, Anders; Ueland, Thor; Reisæter, Anna Varberg; Pischke, Søren Erik; Mollnes, Tom Eirik; Aukrust, Pål; Hartmann, Anders; Heldal, Kristian; Jenssen, Trond
Peer reviewed, Journal article
Published version
Permanent lenke
https://hdl.handle.net/11250/3041726Utgivelsesdato
2022Metadata
Vis full innførselSamlinger
Originalversjon
10.1111/ajt.17047Sammendrag
In the general population low-grade inflammation has been established as a risk factor for all-cause mortality. We hypothesized that an inflammatory milieu beyond the time of recovery from the surgical trauma could be associated with increased long-term mortality in kidney transplant recipients (KTRs). This cohort study included 1044 KTRs. Median follow-up time post-engraftment was 10.3 years. Inflammation was assessed 10 weeks after transplantation by different composite inflammation scores based on 21 biomarkers. We constructed an overall inflammation score and five pathway-specific inflammation scores (fibrogenesis, vascular inflammation, metabolic inflammation, growth/angiogenesis, leukocyte activation). Mortality was assessed with Cox regression models adjusted for traditional risk factors. A total of 312 (29.9%) patients died during the follow-up period. Hazard ratio (HR) for death was 4.71 (95% CI:2.85-7.81, p