dc.contributor.author | Åbjørsbråten, Knut Sindre | |
dc.contributor.author | Skaaraas, Gry HE Syverstad | |
dc.contributor.author | Cunen, Celine Marie Løken | |
dc.contributor.author | Bjørnstad, Daniel Marelius | |
dc.contributor.author | Binder, Kristin M Gullestad | |
dc.contributor.author | Bojarskaite, Laura | |
dc.contributor.author | Jensen, Vidar | |
dc.contributor.author | Nilsson, Lars | |
dc.contributor.author | Rao, Shreyas B. | |
dc.contributor.author | Tang, Wannan | |
dc.contributor.author | Hermansen, Gudmund Horn | |
dc.contributor.author | Nagelhus, Erlend Arnulf | |
dc.contributor.author | Ottersen, Ole Petter | |
dc.contributor.author | Torp, Reidun | |
dc.contributor.author | Enger, Rune | |
dc.date.accessioned | 2023-01-03T07:47:43Z | |
dc.date.available | 2023-01-03T07:47:43Z | |
dc.date.created | 2022-12-20T14:01:19Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2050-084X | |
dc.identifier.uri | https://hdl.handle.net/11250/3040434 | |
dc.description.abstract | Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice. Here, we employ an event-based algorithm to assess astrocytic Ca2+ signals in the neocortex of awake-behaving tg-ArcSwe mice and non-transgenic wildtype littermates while monitoring pupil responses and behavior. We demonstrate an attenuated astrocytic Ca2+ response to locomotion and an uncoupling of pupil responses and astrocytic Ca2+ signaling in 15-month-old plaque-bearing mice. Using the genetically encoded fluorescent norepinephrine sensor GRABNE, we demonstrate a reduced norepinephrine signaling during spontaneous running and startle responses in the transgenic mice, providing a possible mechanistic underpinning of the observed reduced astrocytic Ca2+ responses. Our data points to a dysfunction in the norepinephrine–astrocyte Ca2+ activity axis, which may account for some of the cognitive deficits observed in Alzheimer’s disease. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | eLife Sciences Publications | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice | en_US |
dc.title.alternative | Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.journal | eLIFE | en_US |
dc.identifier.doi | 10.7554/eLife.75055 | |
dc.identifier.cristin | 2095785 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |