dc.contributor.author | Polok, Kamil | |
dc.contributor.author | Fronczek, Jakub | |
dc.contributor.author | Artigas, Antonio | |
dc.contributor.author | Flaatten, Hans Kristian | |
dc.contributor.author | Guidet, Bertrand | |
dc.contributor.author | De Lange, Dylan W. | |
dc.contributor.author | Fjølner, Jesper | |
dc.contributor.author | Leaver, Susannah | |
dc.contributor.author | Beil, Michael | |
dc.contributor.author | Sviri, Sigal | |
dc.contributor.author | Bruno, Raphael Romano | |
dc.contributor.author | Wernly, Bernhard | |
dc.contributor.author | Bollen Pinto, Bernardo | |
dc.contributor.author | Schefold, Joerg C. | |
dc.contributor.author | Studzińska, Dorota | |
dc.contributor.author | Joannidis, Michael | |
dc.contributor.author | Oeyen, Sandra | |
dc.contributor.author | Marsh, Brian | |
dc.contributor.author | Andersen, Finn Husøy | |
dc.contributor.author | Moreno, Rui | |
dc.contributor.author | Cecconi, Maurizio | |
dc.contributor.author | Jung, Christian | |
dc.contributor.author | Szczeklik, Wojciech | |
dc.date.accessioned | 2022-12-14T10:11:05Z | |
dc.date.available | 2022-12-14T10:11:05Z | |
dc.date.created | 2022-10-21T13:50:22Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Critical Care. 2022, 26 (1), . | en_US |
dc.identifier.issn | 1364-8535 | |
dc.identifier.uri | https://hdl.handle.net/11250/3037647 | |
dc.description.abstract | Background
Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. We aimed to evaluate the use of NIV in Europe and factors associated with outcomes of patients treated with NIV.
Methods
This is a substudy of COVIP study—an international prospective observational study enrolling patients aged ≥ 70 years with confirmed COVID-19 treated in ICU. We enrolled patients in 156 ICUs across 15 European countries between March 2020 and April 2021.The primary endpoint was 30-day mortality.
Results
Cohort included 3074 patients, most of whom were male (2197/3074, 71.4%) at the mean age of 75.7 years (SD 4.6). NIV frequency was 25.7% and varied from 1.1 to 62.0% between participating countries. Primary NIV failure, defined as need for endotracheal intubation or death within 30 days since ICU admission, occurred in 470/629 (74.7%) of patients. Factors associated with increased NIV failure risk were higher Sequential Organ Failure Assessment (SOFA) score (OR 3.73, 95% CI 2.36–5.90) and Clinical Frailty Scale (CFS) on admission (OR 1.46, 95% CI 1.06–2.00). Patients initially treated with NIV (n = 630) lived for 1.36 fewer days (95% CI − 2.27 to − 0.46 days) compared to primary IMV group (n = 1876).
Conclusions
Frequency of NIV use varies across European countries. Higher severity of illness and more severe frailty were associated with a risk of NIV failure among critically ill older adults with COVID-19. Primary IMV was associated with better outcomes than primary NIV. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | BMC | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study | en_US |
dc.title.alternative | Noninvasive ventilation in COVID-19 patients aged ≥ 70 years—a prospective multicentre cohort study | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 0 | en_US |
dc.source.volume | 26 | en_US |
dc.source.journal | Critical Care | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1186/s13054-022-04082-1 | |
dc.identifier.cristin | 2063757 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |