dc.contributor.author | Wolff, Georg | |
dc.contributor.author | Wernly, Bernhard | |
dc.contributor.author | Flaatten, Hans Kristian | |
dc.contributor.author | Fjølner, Jesper | |
dc.contributor.author | Bruno, Raphael Romano | |
dc.contributor.author | Artigas, Antonio | |
dc.contributor.author | Pinto, Bernardo Bollen | |
dc.contributor.author | Schefold, Joerg C. | |
dc.contributor.author | Kelm, Malte | |
dc.contributor.author | Binneboessel, Stephan | |
dc.contributor.author | Baldia, Philipp | |
dc.contributor.author | Beil, Michael | |
dc.contributor.author | Sivri, Sigal | |
dc.contributor.author | van Heerden, Peter Vernon | |
dc.contributor.author | Szczeklik, Wojciech | |
dc.contributor.author | Elhadi, Muhammed | |
dc.contributor.author | Joannidis, Michael | |
dc.contributor.author | Oeyen, Sandra | |
dc.contributor.author | Flamm, Maria | |
dc.contributor.author | Zafeiridis, Tilemachos | |
dc.contributor.author | Marsh, Brian | |
dc.contributor.author | Andersen, Finn Husøy | |
dc.contributor.author | Moreno, Rui | |
dc.contributor.author | Boumendil, Ariane | |
dc.contributor.author | De Lange, Dylan W. | |
dc.contributor.author | Guidet, Bertrand | |
dc.contributor.author | Leaver, Susannah | |
dc.contributor.author | Jung, Christian | |
dc.date.accessioned | 2022-12-01T08:01:49Z | |
dc.date.available | 2022-12-01T08:01:49Z | |
dc.date.created | 2022-11-02T14:07:13Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Canadian Journal of Anesthesia. 2022, 69 1390-1398. | en_US |
dc.identifier.issn | 0832-610X | |
dc.identifier.uri | https://hdl.handle.net/11250/3035169 | |
dc.description.abstract | Purpose
Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific differences in treatment and outcome after intensive care unit (ICU) admission in this cohort.
Methods
We performed a sex-specific analysis in critically ill patients ≥ 70 yr of age with COVID-19 who were included in the international prospective multicenter COVIP study. All patients were analyzed for ICU admission and treatment characteristics. We performed a multilevel adjusted regression analysis to elucidate associations of sex with 30-day mortality.
Results
A total of 3,159 patients (69.8% male, 30.2% female; median age, 75 yr) were included. Male patients were significantly fitter than female patients as determined by the Clinical Frailty Scale (fit, 67% vs 54%; vulnerable, 14% vs 19%; frail, 19% vs 27%; P < 0.001). Male patients more often underwent tracheostomy (20% vs 14%; odds ratio [OR], 1.57; P < 0.001), vasopressor therapy (69% vs 62%; OR, 1.25; P = 0.02), and renal replacement therapy (17% vs 11%; OR, 1.96; P < 0.001). There was no difference in mechanical ventilation, life-sustaining treatment limitations, and crude 30-day mortality (50% male vs 49% female; OR, 1.11; P = 0.19), which remained true after adjustment for disease severity, frailty, age and treatment limitations (OR, 1.17; 95% confidence interval, 0.94 to 1.45; P = 0.16).
Conclusion
In this analysis of sex-specific treatment characteristics and 30-day mortality outcomes of critically ill patients with COVID-19 ≥ 70 yr of age, we found more tracheostomy and renal replacement therapy in male vs female patients, but no significant association of patient sex with 30-day mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study | en_US |
dc.title.alternative | Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age—results from the prospective COVIP study | en_US |
dc.title.alternative | Caractéristiques des traitements en fonction du sexe et résultats de mortalité à 30 jours des patients atteints de COVID-19 gravement malades de plus de 70 ans—résultats de l’étude prospective COVIP | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 1390-1398 | en_US |
dc.source.volume | 69 | en_US |
dc.source.journal | Canadian Journal of Anesthesia | en_US |
dc.identifier.doi | 10.1007/s12630-022-02304-2 | |
dc.identifier.cristin | 2068120 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |