dc.contributor.author | Arjmandi, Hamidreza | |
dc.contributor.author | Zoofaghari, Mohammad | |
dc.contributor.author | Rouzegar, Seyed Vahid | |
dc.contributor.author | Veletic, Mladen | |
dc.contributor.author | Balasingham, Ilangko Sellappah | |
dc.date.accessioned | 2022-10-24T07:39:06Z | |
dc.date.available | 2022-10-24T07:39:06Z | |
dc.date.created | 2022-01-23T13:07:14Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | IEEE Transactions on Nanobioscience. 2021, 20 (1), 105-115. | en_US |
dc.identifier.issn | 1536-1241 | |
dc.identifier.uri | https://hdl.handle.net/11250/3027759 | |
dc.description.abstract | Blood vessels are flow-induced diffusive molecular channels equipped with transport mechanisms across their walls for conveying substances between the organs in the body. Mathematical modeling of the blood vessel as a molecular transport channel can be used for the characterization of the underlying processes and higher-level functions in the circulatory system. Besides, the mathematical model can be utilized for designing and realizing nano-scale molecular communication systems for healthcare applications including drug delivery systems. In this paper, a continuous-time Markov chain framework is proposed to simply model active transport mechanisms e.g. transcytosis, across the single-layered endothelial cells building the inner vessel wall. Correspondingly, a general homogeneous boundary condition over the vessel wall is introduced. Coupled with the derived boundary condition, the flow-induced diffusion problem in an ideal vessel structure with a cylindrical shape is accurately formulated which takes into account variation in all three dimensions. The corresponding concentration Green's function is analytically derived in terms of a convergent infinite series. Particle-based simulation results confirm the proposed analysis. Also, the effects of system parameters on the concentration Green's function are examined. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Institute of Electrical and Electronics Engineers (IEEE) | en_US |
dc.title | On Mathematical Analysis of Active Drug Transport Coupled with Flow-induced Diffusion in Blood Vessels | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | This version of the article will not be available due to copyright restrictions by IEEE | en_US |
dc.source.pagenumber | 105-115 | en_US |
dc.source.volume | 20 | en_US |
dc.source.journal | IEEE Transactions on Nanobioscience | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1109/TNB.2020.3038635 | |
dc.identifier.cristin | 1988038 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |