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dc.contributor.authorEftedal, Ingrid
dc.contributor.authorFredriksen, Hallvard Aglen
dc.contributor.authorHjelde, Astrid
dc.contributor.authorMøllerløkken, Andreas
dc.date.accessioned2015-06-12T06:16:42Z
dc.date.accessioned2015-09-14T14:32:26Z
dc.date.available2015-06-12T06:16:42Z
dc.date.available2015-09-14T14:32:26Z
dc.date.issued2015
dc.identifier.citationPhysiological Reports 2015, 3(6)nb_NO
dc.identifier.issn2051-817X
dc.identifier.urihttp://hdl.handle.net/11250/299784
dc.description.abstractPlasminogen activator inhibitor (PAI-1) is induced in the vasculature and secreted into the vascular lumen in response to inflammation and oxidative stress. We have previously reported a fivefold increase in plasma PAI-1 from rats exposed to 708 kPa hyperbaric air. In the current study we assess the potential of human serum total PAI-1 as a biomarker for stress in compressed air diving. Eleven recreational divers, nine males and two females, completed four 2 h hyperbaric air exposures to 280 kPa in a pressure chamber over a period of 2 weeks. The air pressure corresponds to a diving depth of 18 m in water. Serum was collected before the study and again 3 h 30 min after com- pletion of each hyperbaric exposure. All samples were taken in the afternoon to minimize the contribution of circadian variation. The analysis revealed no change in serum total PAI-1 after hyperbaric exposures within the group of divers (P = 0.064), but significant interindividual differences persisted throughout the study (P < 0.0005). A case of decompression sickness after the third round of hyperbaric exposure did not affect PAI-1. In conclusion, com- pressed air exposure to 280 kPa does not affect serum total PAI-1, and signifi- cant interindividual variation in PAI-1 levels may limit its usefulness as a biomarker. This does, however, not give a complete answer regarding PAI-1 in physiologically stressful dives. Further studies with different exposures and timing are needed for that.nb_NO
dc.language.isoengnb_NO
dc.publisherWiley Open Accessnb_NO
dc.titleEvaluating PAI-1 as a biomarker for stress in diving: human serum total PAI-1 is unaltered after 2 h dry exposures to 280 kPa hyperbaric airnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-06-12T06:16:42Z
dc.source.volume3nb_NO
dc.source.journalPhysiological Reportsnb_NO
dc.source.issue6nb_NO
dc.identifier.doi10.14814/phy2.12437
dc.identifier.cristin1247705
dc.relation.projectNorges forskningsråd: 220546nb_NO
dc.description.localcode(c) 2013 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.nb_NO


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