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dc.contributor.authorSol, Chalana M
dc.contributor.authorSantos, Susana
dc.contributor.authorAsimakopoulos, Alexandros
dc.contributor.authorMartinez-Moral, Maria-Pilar
dc.contributor.authorDuijts, Liesbeth
dc.contributor.authorKannan, Kurunthachalam
dc.contributor.authorTrasande, Leonardo
dc.contributor.authorJaddoe, Vincent WV
dc.date.accessioned2022-05-11T07:38:31Z
dc.date.available2022-05-11T07:38:31Z
dc.date.created2020-05-07T15:47:01Z
dc.date.issued2020
dc.identifier.citationEnvironment International. 2020, 138 1-8.en_US
dc.identifier.issn0160-4120
dc.identifier.urihttps://hdl.handle.net/11250/2995172
dc.description.abstractObjectives Fetal exposure to phthalates and bisphenols may lead to vascular developmental adaptations, which program later cardiovascular disease. We examined the associations of fetal exposure to phthalates and bisphenols with childhood blood pressure. Methods In a population-based, prospective cohort study among 1,064 mother-child pairs, we measured maternal urine phthalate and bisphenol concentrations in first, second and third trimester of pregnancy. We measured childhood blood pressure at the mean age of 9.7 years (standard deviation 0.2 years) old. Analyses were performed for the total group, and for boys and girls separately. Results Maternal urine phthalate concentrations were not associated with childhood blood pressure among boys. Higher third trimester maternal urine concentrations of high molecular weight phthalates (HMWP), di-2-ehtylhexylphthalate (DEHP) and di-n-octylphthalate (DNOP) were associated with lower systolic and diastolic blood pressure among girls (p-values < 0.01). Also, higher second trimester maternal urine total bisphenol and bisphenol A concentrations were associated with higher systolic blood pressure among boys (p values < 0.01), but tended to be associated with a lower diastolic blood pressure among girls. Conclusions Our results suggest sex-dependent associations of maternal urine phthalate and bisphenol concentrations during pregnancy with childhood blood pressure. Further studies are needed to explore the underlying mechanisms and long term consequences.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAssociations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort studyen_US
dc.title.alternativeAssociations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-8en_US
dc.source.volume138en_US
dc.source.journalEnvironment Internationalen_US
dc.identifier.doi10.1016/j.envint.2020.105677
dc.identifier.cristin1809840
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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