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dc.contributor.authorLiu, Chang
dc.contributor.authorGao, Jianbo
dc.contributor.authorCui, Xinxin
dc.contributor.authorLi, Zhipeng
dc.contributor.authorChen, Lei
dc.contributor.authorYuan, Yuan
dc.contributor.authorZhang, Yaolei
dc.contributor.authorMei, Liangwei
dc.contributor.authorZhao, Lan
dc.contributor.authorCai, Dan
dc.contributor.authorHu, Mingliang
dc.contributor.authorZhou, Botong
dc.contributor.authorLi, Zihe
dc.contributor.authorQin, Tao
dc.contributor.authorSi, Huazhe
dc.contributor.authorLi, Guangyu
dc.contributor.authorLin, Zeshan
dc.contributor.authorXu, Yicheng
dc.contributor.authorZhu, Chenglong
dc.contributor.authorYin, Yuan
dc.contributor.authorZhang, Chenzhou
dc.contributor.authorXu, Wenjie
dc.contributor.authorLi, Qingjie
dc.contributor.authorWang, Kun
dc.contributor.authorGilbert, Marcus Thomas Pius
dc.contributor.authorHeller, Rasmus
dc.contributor.authorWang, Wen
dc.contributor.authorHuang, Jinghui
dc.contributor.authorQiu, Qiang
dc.date.accessioned2022-02-28T14:33:37Z
dc.date.available2022-02-28T14:33:37Z
dc.date.created2021-11-19T16:14:51Z
dc.date.issued2021
dc.identifier.citationScience Advances. 2021, 7 (12), .en_US
dc.identifier.issn2375-2548
dc.identifier.urihttps://hdl.handle.net/11250/2981798
dc.description.abstractThe suite of adaptations associated with the extreme stature of the giraffe has long interested biologists and physiologists. By generating a high-quality chromosome-level giraffe genome and a comprehensive comparison with other ruminant genomes, we identified a robust catalog of giraffe-specific mutations. These are primarily related to cardiovascular, bone growth, vision, hearing, and circadian functions. Among them, the giraffe FGFRL1 gene is an outlier with seven unique amino acid substitutions not found in any other ruminant. Gene-edited mice with the giraffe-type FGFRL1 show exceptional hypertension resistance and higher bone mineral density, both of which are tightly connected with giraffe adaptations to high stature. Our results facilitate a deeper understanding of the molecular mechanism underpinning distinct giraffe traits, and may provide insights into the study of hypertension in humans.en_US
dc.language.isoengen_US
dc.publisherAmerican Association for the Advancement of Scienceen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleA towering genome: Experimentally validated adaptations to high blood pressure and extreme stature in the giraffeen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber12en_US
dc.source.volume7en_US
dc.source.journalScience Advancesen_US
dc.source.issue12en_US
dc.identifier.doi10.1126/sciadv.abe9459
dc.identifier.cristin1956644
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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