dc.contributor.author | Omtvedt, Line Aanerud | |
dc.contributor.author | Kristiansen, Kåre Andre | |
dc.contributor.author | Strand, Wenche Iren | |
dc.contributor.author | Aachmann, Finn Lillelund | |
dc.contributor.author | Strand, Berit Løkensgard | |
dc.contributor.author | Zaytseva-Zotova, Daria Sergeevna | |
dc.date.accessioned | 2021-11-01T13:59:58Z | |
dc.date.available | 2021-11-01T13:59:58Z | |
dc.date.created | 2021-08-31T23:28:31Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Journal of Biomedical Materials Research. 2021, 2021 . | en_US |
dc.identifier.issn | 0021-9304 | |
dc.identifier.uri | https://hdl.handle.net/11250/2826969 | |
dc.description.abstract | Modification of drug delivery materials with beta-cyclodextrins (β-CyD) is known to increase solubility of poorly water-soluble drugs, protect drugs from degradation and sustain release. In this study, we developed a hydrogel drug delivery system for local paclitaxel delivery using the natural polysaccharide alginate functionalized with β-CyD-moieties. Paclitaxel was chosen due to its ability to form inclusion complexes with cyclodextrins. The rheological and mechanical properties of the prepared hydro- gels were characterized, as well as in vitro release of the paclitaxel and in vitro activ- ity on PC-3 prostate cancer cells. Introduction of β-CyD-moieties into the hydrogel reduces the mechanical properties of the gels compared to nonmodified gels. How- ever, gelation kinetics were not markedly different. Furthermore, the β-CyD-modified alginate helped to reduce undesired crystallization of the paclitaxel in the gel and facilitated paclitaxel diffusion out of the gel network. Remarkably, the β-CyD grafted alginate showed increased capacity to complex paclitaxel compared to free HPβ- CyD. Release of both paclitaxel and degradation products were measured from the gels and were shown to have cytotoxic effects on the PC-3 cells. The results indicate that functionalized alginate with β-CyDs has potential as a material for drug delivery systems. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Alginate hydrogels functionalized with β-cyclodextrin as a local paclitaxel delivery system | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 15 | en_US |
dc.source.volume | 2021 | en_US |
dc.source.journal | Journal of Biomedical Materials Research | en_US |
dc.identifier.doi | 10.1002/jbm.a.37255 | |
dc.identifier.cristin | 1930271 | |
dc.relation.project | Norges forskningsråd: 250875 | en_US |
dc.relation.project | Norges forskningsråd: 221576 | en_US |
dc.relation.project | Norges forskningsråd: 269273/O70 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 0 | |