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dc.contributor.authorHaldorsen, Ingfrid S.
dc.contributor.authorStefansson, Ingunn
dc.contributor.authorGrüner, Renate
dc.contributor.authorHusby, Jenny Hild Aase
dc.contributor.authorMagnussen, Inger Johanne
dc.contributor.authorWerner, Henrica Maria Johanna
dc.contributor.authorSalvesen, Øyvind
dc.contributor.authorBjørge, Line
dc.contributor.authorTrovik, Jone
dc.contributor.authorTaxt, Torfinn
dc.contributor.authorAkslen, Lars A.
dc.contributor.authorSalvesen, Helga Birgitte
dc.date.accessioned2015-04-08T09:47:23Z
dc.date.accessioned2015-04-24T12:04:33Z
dc.date.available2015-04-08T09:47:23Z
dc.date.available2015-04-24T12:04:33Z
dc.date.issued2013-10-31
dc.identifier.citationBritish Journal of Cancer 2014, 110(1):107-114nb_NO
dc.identifier.issn1532-1827
dc.identifier.urihttp://hdl.handle.net/11250/282433
dc.description.abstractBackground: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) and to explore the potential value of these markers to identify patients with poor outcome. Methods: In fifty-four surgically staged endometrial carcinoma patients, immunohistochemical staining with factor VIII and Ki67 allowed assessment of microvessel density (MVD) and microvascular proliferation reflecting tumour angiogenesis. In the same patients, preoperative pelvic DCE-MRI and DWI allowed the calculation of parameters describing tumour microvasculature and microstructure in vivo. Results: Microvascular proliferation was negatively correlated to tumour blood flow (Fb) (r ¼ 0.36, P ¼ 0.008), capillary permeability surface area product (PS) (r ¼ 0.39, P ¼ 0.004) and transfer from the blood to extravascular extracellular space (EES) (Ktrans) (r ¼ 0.40, P ¼ 0.003), and was positively correlated to tumour volume (r ¼ 0.34; P ¼ 0.004). High-tumour microvascular proliferation, low Fb and low Ktrans were all significantly associated with reduced progression/recurrence-free survival (Po 0.05). Conclusion: Disorganised angiogenesis with coexisting microvascular proliferation and low tumour blood flow is a poor prognostic factor supporting that hypoxia is associated with progression and metastatic spread in endometrial carcinomas.nb_NO
dc.language.isoengnb_NO
dc.publisherNature Publishing Groupnb_NO
dc.titleIncreased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomasnb_NO
dc.typeJournal articlenb_NO
dc.typePeer revieweden_GB
dc.date.updated2015-04-08T09:47:23Z
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756nb_NO
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Gynaecology and obstetrics: 756nb_NO
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk mikrobiologi : 715nb_NO
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical microbiology: 715nb_NO
dc.source.pagenumber107-114nb_NO
dc.source.volume110nb_NO
dc.source.journalBritish Journal of Cancernb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1038/bjc.2013.694
dc.identifier.cristin1112321
dc.description.localcodeOpen access article distributed under a Creative Commons CC-BY license. (C) 2014 Cancer Research UK. All rights reserved 0007 – 0920/14nb_NO


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